Adenosquamous carcinoma of breast in a 19 years old woman: a case report

Agrawal, Amit; Saha, Shopon; Ellis, Ian O.; Bello, A.

doi:10.1186/1477-7819-8-44

Cited by 21 publications

(25 citation statements)

References 10 publications

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“…In the low-grade form, the prognosis is good, (1) with a low probability of metastasis or contralateral disease reported thus far. (2) As shown in the four cases reported by Ho et al, (4) where fine needle aspiration and core biopsy were not able to yield sufficient tissue for precise histologic diagnosis, arriving at the final diagnosis is difficult in low-grade adenosquamous carcinomas. Van Hoeven et al (3) reported 32 cases of low-grade adenosquamous carcinoma of the breast.…”

Section: Discussionmentioning

confidence: 99%

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Lactating breast abscess: a rare presentation of adenosquamous breast carcinoma

Alipour

Seifollahi

Anbiaee

2013

smedj

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C a s e R e p o r t e247 I NTRO D U C TIO NInflammatory disorders of the breast, including mastitis and breast abscesses, are generally benign diseases that rarely harbour malignancy. Although the occurrence of cancer is not anticipated in true breast abscesses in nursing mothers, it can occasionally happen. Herein, we present a rare case of adenosquamous carcinoma of the breast in a 33-year-old lactating woman who presented with a breast abscess. CA S E R EPO RTA 33-year-old lactating woman presented to our breast clinic with signs of inflammation in her left breast -the skin was largely erythematous and warm over a tender 10-cm fluctuating mass, and several soft, non-suspicious lymphadenopathies were observed in the left axilla. According to the patient, the inflammation began two months prior to presentation and temporarily subsided with the use of oral antibiotics; when the use of oral antibiotics was discontinued, the inflammation flared up. Ultrasonography performed one month prior to presentation showed a multiloculated 93-mm × 82-mm × 63-mm fluidcontaining cavity in the left breast, which was suggestive of a breast abscess, and large reactive axillary lymph nodes in the same side.Intravenous antibiotics were prescribed, lactation ceased, and the cavity was surgically drained, yielding more than 300 mL of diluted pus. As routinely done in our institution, multiple biopsies were performed using the tissue obtained from the abscess wall. of the chest, abdomen and pelvis, and a bone scan of the whole body, was negative. The patient had no family history of breast cancer, and no other known risk factor was detected.Before proceeding with cancer treatment, we had to first determine whether the abscess was an inflammatory carcinoma or an invasive noninflammatory carcinoma presenting as an abscess. Although the inflammatory signs of the breast were in favour of the former diagnosis, a mismanaged large and persistent breast abscess is not uncommon in milk-laden breasts. Hence, the possibility of a lactating abscess superimposed on a typical invasive tumour was considered. However, since the pathologist who reviewed the histology slides could not detect any cancerous involvement in the dermal lymphatics, it was decided that the disease would be treated as a large noninflammatory invasive breast cancer.Following the diagnosis, the surgical wound was immediately closed to allow rapid initiation of neoadjuvant chemotherapy, which involved four cycles of treatment with cyclophosphamide, epirubicin and 5-fluorouracil, followed by four cycles of treatment with taxotere. As the patient did not consent to a mastectomy, breast-conserving surgery with a wide normal margin and axillary dissection was performed. The postoperative course was uneventful. Postoperative radiotherapy consisted of a 5,000-cGy breast and regional lymphatic area irradiation and a 1,000-cGy irradiation boost to the tumour bed. ABSTRACT We report the case of a 33-year-old lactating woman who presented with a 10-cm breast abscess.Biopsy of the abscess w...

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Section: Discussionmentioning

confidence: 99%

“…(1) Although these rare tumours, which are probably a variant of metaplastic carcinomas, (1)(2)(3)(4) present mainly in low-grade forms, (3) they are also seen as high-grade tumours. In the low-grade form, the prognosis is good, (1) with a low probability of metastasis or contralateral disease reported thus far.…”

Section: Discussionmentioning

confidence: 99%

Lactating breast abscess: a rare presentation of adenosquamous breast carcinoma

Alipour

Seifollahi

Anbiaee

2013

smedj

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“…Adenosquamous carcinoma of the breast is a rare cancer that occurs as one of the variants of metaplastic breast carcinoma (5). Adenosquamous carcinoma has a prevalence of <1% of all breast cancers (7).…”

Section: Discussionmentioning

confidence: 99%

“…Second primary breast cancer generally develops in women who are first diagnosed with endometrial colon/rectal, stomach, ovarian, thyroid gland or skin cancers, although its occurrence following AML is rare (4). Additionally, adenosquamous carcinoma of the breast is a rare tumor that exists as one of the subgroups of metaplastic breast carcinoma (5). Metaplastic carcinoma occurs at a prevalence of 1% of all breast carcinomas (6).…”

Section: Introductionmentioning

confidence: 99%

Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report

Hashemi

Shan²,

Jahantigh

et al. 2017

Molecular and Clinical Oncology

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Abstract. Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests of squamous cells in a spindle cell background. Furthermore, its occurrence following AML is also rare. To the best of our knowledge, based on a review of the relevant literature, thus far there have not been any welldocumented cases. In the present case report, we report on a middle-aged woman with a 2year history of acute myeloid leukemia (AML) who was admitted to hospital due to a mass in the right breast, with concurrent cutaneous lesions on the breast. The clinical and pathological investigations resulted in the diagnosis of adenosquamous carcinoma of the breast. The patient underwent a modified radical mastectomy (MRM). Subsequently, the patient received chemotherapy, involved-field radiation therapy and target therapy. At 9 months after the final cycle of chemotherapy, and while she was on targeted therapy with trastuzumab (6 mg administered every 3 weeks), the patient presented with extensive dermatomal skin lesions. A biopsy report revealed metastatic lesions of invasive ductal carcinoma in the abdomen, so chemotherapy resumed with a course lasting for 6 cycles, with the identical treatments, but lacking trastuzumab.

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“…The latter tumour is a rare breast carcinoma showing a prominent glandular pattern (figure 1), also exhibiting focal squamous differentiation (figures 2 and 3). This tumour shows a positive immunohistochemical reaction to myoepithelial cell markers3 (figure 4). This picture, particularly in a core biopsy, would be difficult to be accurately interpreted and may lead to the erroneous diagnosis of a benign lesion resulting in undertreatment 4.…”

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confidence: 97%