Adenosis Tumor of the Breast

Markopoulos, Christos; Kouskos, E; Phillipidis, T.; Floros, D.

doi:10.1046/j.1524-4741.2003.09324.x

Cited by 7 publications

(4 citation statements)

References 4 publications

(9 reference statements)

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“…SA is a benign proliferative disease of the breast that has an increased incidence among reproductive-age and perimenopausal women, especially between 35 and 50 years of age. [1–2,7] The pathological manifestations of SA are complex and various, and it can coexist with other proliferative lesions as well as malignancies. Previous studies have demonstrated that SA had a risk for the development of invasive breast carcinoma, [2–5] and it sometimes was regarded as precancerous lesions.…”

Section: Discussionmentioning

confidence: 99%

“…It is usually an incidental finding in perimenopausal women undergoing screening mammography or histopathological examination performed for other reasons. [1] SA can be observed as a component of other benign or malignant proliferative processes. Though SA is not considered a premalignant lesion, it is associated with a doubling of the risk of developing breast carcinoma; and some studies have demonstrated a 1.7 to 3.7 times relative risk for the development of invasive breast carcinoma in patients with SA.…”

Section: Introductionmentioning

confidence: 99%

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Radiological and clinical findings in sclerosing adenosis of the breast

et al. 2019

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To study the imaging and clinical features of breast sclerosing adenosis (SA), and to enhance the recognition of this disease, as well as to help the clinic to give a correct diagnosis.Imaging findings were retrospectively reviewed in 47 women with SA lesions confirmed by pathology (including 39 cases of mammography, 40 cases of ultrasound [US], and 34 cases magnetic resonance imaging [MRI]).Of 47 patients confirmed with SA, 18 cases were pure SA, and 29 cases coexist with other proliferative lesions and malignancies; the maximum diameter of SA lesions was 0.5 to 3.5 cm with an average of 1.6 cm. On the mammogram of 39 SA cases, the percentage of architectural distortion, calcifications, mass/nodular, asymmetric density, and mass combining with calcifications were 30.8%, 23.1%, 17.9%, 12.8%, and 7.7%, respectively; and 3 cases had no abnormal findings. On the sonogram (excluding 5 normal finding cases), the majority of lesions showed regular shaped (57.1%), well defined margined (60.0%), heterogenous low echoed (71.4%) nodulus. 85.3% lesions showed high signal on T2-weighted images, and all lesions were enhanced markedly, including 82.4% lesions appearing mass-like enhancement (17 star-shaped enhanced masses included); and the percentage of the time-signal intensity curve in type 1, type 2, and type 3 were 52.9%, 41.2%, and 5.9%, respectively. If the category breast imaging-reporting and data system ≥4b was considered to be a suspicious malignant lesion, the misdiagnostic rates of mammography, US, and MRI would be 17.9%, 17.5%, and 35.3%, respectively.The SA lesions are small and can occur with other diseases histologically. The majority of SA lesions showed distortion or calcifications on mammograms, low echo-level nodules with heterogenous echo on US and mass-like lesion with or without star shape on enhanced MRI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiological and clinical findings in sclerosing adenosis of the breast

et al. 2019

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“…The presence of typical benign cell clusters, few bipolar cells and the absence of fat infiltration restricted us from the diagnosis of an infiltrating ductal carcinoma. Markopoulos, et al .,[5] have also reported a similar false-positive case. Even in the study by Cho, et al .,[7] none of the seven cases were originally diagnosed as sclerosing adenosis.…”

Section: Discussionmentioning

confidence: 73%

“…It usually presents in the perimenopausal age group. [5] It poses a diagnostic confusion with infiltrating lobular carcinomas and tubular carcinomas even in histological sections, but is identified by the relative preservation of overall lobular architecture, the compressed glands, lack of atypia, the retention of two cell layers, and the confirmation of the presence of myoepithelial cells by immunohistochemistry. [2] It could be associated with microcysts, apocrine metaplasia, luminal histiocytes and pseudopapillomas, called glomeruloid structures.…”

Section: Discussionmentioning

confidence: 99%

Nodular sclerosing adenosis of breast: A diagnostic pitfall in fine needle aspiration cytology

Sreedharanunni

Das

Singla

et al. 2013

J Cytol

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Fine needle aspiration cytology was performed in a 46-year-old female presenting with a breast lump and mammography suggesting a malignancy. The smears were cellular with cohesive clusters and scattered epithelial cells showing moderate nuclear pleomorphism and focal acinar formation. Stromal fragments, benign epithelial cell clusters and a few naked nuclei were noted in the background. Considering the clinical features, mammography findings as well as cytological features, a diagnosis of ductal carcinoma was suggested. Subsequent histopathological examination revealed it to be nodular sclerosing adenosis. The cytohistological correlation of this uncommon lesion, a potential pitfall in breast fine needle aspiration diagnosis which may lead to a false-positive diagnosis is discussed.

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Benign Sclerosing Lesions

Tan

Şahin

2017

Atlas of Differential Diagnosis in Breast Pathology

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Adenosis Tumor of the Breast

Cited by 7 publications

References 4 publications

Radiological and clinical findings in sclerosing adenosis of the breast

Radiological and clinical findings in sclerosing adenosis of the breast

Nodular sclerosing adenosis of breast: A diagnostic pitfall in fine needle aspiration cytology

Benign Sclerosing Lesions

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