Adenosine triphosphate synthesis, mitochondrial number and activity, and pyruvate uptake in oocytes after gonadotropin injections

Lee, Seung Tae; Oh, Seo Jin; Lee, Eun Ju; Han, Ho Jae; Lim, Jeong Mook

doi:10.1016/j.fertnstert.2006.01.059

Cited by 16 publications

(11 citation statements)

References 23 publications

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“…The mitochondrial transcription factors then direct mtDNA transcription and replication (13,(15)(16)(17). Many tissues adjust mitochondrial mass and cellular mtDNA content physiologically through mitochondrial biogenesis (18)(19)(20)(21)(22), and data suggest a role for biogenesis in the response to inflammatory conditions including sepsis (6)(7)(8)(9).…”

mentioning

confidence: 99%

Mitochondrial Biogenesis Restores Oxidative Metabolism during Staphylococcus aureus Sepsis

Haden

Suliman²,

Carraway³

et al. 2007

Am J Respir Crit Care Med

164

142

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Rationale: The extent, timing, and significance of mitochondrial injury and recovery in bacterial sepsis are poorly characterized, although oxidative and nitrosative mitochondrial damage have been implicated in the development of organ failure. Objectives: To define the relationships between mitochondrial biogenesis, oxidative metabolism, and recovery from Staphylococcus aureus sepsis. Methods: We developed a murine model of fibrin clot peritonitis, using S. aureus. The model yielded dose-dependent decreases in survival and resting energy expenditure, allowing us to study recovery from sublethal sepsis. Measurements and Main Results: Peritonitis caused by 10 6 colonyforming units of S. aureus induced a low tumor necrosis factor-a state and minimal hepatic cell death, but activated prosurvival protein kinase A, B, and C sequentially over 3 days. Basal metabolism by indirect calorimetry was depressed because of selective mitochondrial oxidative stress and subsequent loss of mitochondrial DNA copy number. During recovery, mitochondrial biogenesis was strongly activated by regulated expression of the requisite nuclear respiratory factors 1 and 2 and the coactivator peroxisome proliferatoractivated receptor g coactivator-1a, as well as by repression of the biogenesis suppressor nuclear receptor interacting protein-140. Biogenesis reconstituted mitochondrial DNA copy number and transcription, and restored basal metabolism without significant hepatocellular proliferation. These events dramatically increased hepatic mitochondrial density in transgenic mice expressing mitochondrially targeted green fluorescent protein.Conclusions: This is the first demonstration that mitochondrial biogenesis restores oxidative metabolism in bacterial sepsis and is therefore an early and important prosurvival factor.

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mentioning

confidence: 99%

Mitochondrial Biogenesis Restores Oxidative Metabolism during Staphylococcus aureus Sepsis

Haden

Suliman²,

Carraway³

et al. 2007

Am J Respir Crit Care Med

164

142

View full text Add to dashboard Cite

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“…We did not super-ovulate prior to copulation since it has been reported that gonadotropins (e.g. hCG) can inflate ATP levels and mtDNA copy number rodents 185 . We analyzed 219 cleavage stage embryos and found an average of 161,000 + 73,000 copies of mitochondrial DNA (Figure 1) (median: 154,000 copies, range:…”

Section: Defining the Developmental Threshold Of Mitochondrial Dna Inmentioning

confidence: 99%

Germline Transmission of Mitochondrial DNA in the Mouse.

Wai

Zhang

et al. 2010

Biology of Reproduction

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“…It is well known that oocyte maturation process depends on FSH and LH stimulation and oocyte-follicle interaction ) and superovulation treatments could affect to granulosa cells activity or accelerate follicular growth (Blondin et al, 1996). In fact, an effect on ATP content by superovulation treatment it has been described previously both in mouse (Combelles y Albertini, 2003) and hamster (Lee et al, 2006).…”

Section: Discussionmentioning

confidence: 93%

“…Dado que el metabolismo oxidativo es la principal fuente de energía durante la maduración y tanto la división celular, como la movilización del sistema de microfilamentos requieren altos niveles de energía (Lee et al, 2006b), se considera esencial una producción adecuada de ATP. De hecho, parece que determinados defectos metabólicos están asociados a fallos preimplantatorios (Van Blerkom et al, 1995) y que existe una relación entre la concentración de ATP de los ovocitos y la capacidad de desarrollo de los embriones resultantes (Van Blerkom et al, 1995;Stojkovic et al, 2001;Tamassia et al, 2004).…”

Section: Maduración Molecularunclassified

“…Sin embargo, no siempre un alto ∆Ψm se corresponde con un aumento en la producción de ATP (Van Blerkom et al, 2003;Jones et al, 2004); de hecho, ésta es una útil determinación que aporta información adicional sobre el estado metabólico de los ovocitos y que se ha llevado a cabo en numerosas ocasiones y especies (Van Blerkom et al, 1995;Van Blerkom et al, 2003;Jones et al, 2004;Lee et al, 2006b), incluyendo el conejo (Salvetti et al, 2010), ya que existe una gran correlación entre la concentración del ATP en el ovocito y la capacidad de desarrollo del embrión resultante (Van Blerkom et al, 1995;Stojkovic et al, 2001;Tamassia et al, 2004;. Esta determinación puede llevarse a cabo también en el caso de los embriones .…”

Section: Actividad Metabólicaunclassified

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Efecto De La Aplicación De Gonadotropinas Recombinantes Humanas Sobre La Producción Y Calidad De Ovocitos Y Embriones en Coneja

Nicolau¹

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Adenosine triphosphate synthesis, mitochondrial number and activity, and pyruvate uptake in oocytes after gonadotropin injections

Cited by 16 publications

References 23 publications

Mitochondrial Biogenesis Restores Oxidative Metabolism during Staphylococcus aureus Sepsis

Mitochondrial Biogenesis Restores Oxidative Metabolism during Staphylococcus aureus Sepsis

Germline Transmission of Mitochondrial DNA in the Mouse.

Efecto De La Aplicación De Gonadotropinas Recombinantes Humanas Sobre La Producción Y Calidad De Ovocitos Y Embriones en Coneja

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