Adenosine triphosphate can maintain multipotent haemopoietic stem cells in the absence of interleukin 3 via a membrane permeabilization mechanism

Whetton, Anthony D.; Huang, S J; Monk, Peter N.

doi:10.1016/s0006-291x(88)80408-x

Cited by 14 publications

(7 citation statements)

References 10 publications

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Section: Discussionmentioning

confidence: 99%

“…Our findings suggest roles for calcium release and influx stimulated by ATP and other signals in the control of neurogenesis in the adult mammalian brain. Although effects of ATP on NPC have not previously been described, it was reported that ATP can affect the proliferation of multipotent hematopoeitic stem cells (Whetton et al 1988). ATP can be released from neurons and astrocytes in response to activity in neural circuits (Sawynok et al 1993;Santos et al 1999) suggesting the possibility that ATP plays a role in activity-dependent regulation of NPC proliferation and survival (Kempermann et al 1997;van Praag et al 1999).…”

Section: Discussionmentioning

confidence: 99%

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Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

Haughey

Nath

Chan

et al. 2002

Journal of Neurochemistry

433

299

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Neurogenesis occurs in the adult mammalian brain and may play roles in learning and memory processes and recovery from injury, suggesting that abnormalities in neural progenitor cells (NPC) might contribute to the pathogenesis of disorders of learning and memory in humans. The objectives of this study were to determine whether NPC proliferation, survival and neuronal differentiation are impaired in a transgenic mouse model of Alzheimer's disease (AD), and to determine the effects of the pathogenic form of amyloid b-peptide (Ab) on the survival and neuronal differentiation of cultured NPC. The proliferation and survival of NPC in the dentate gyrus of the hippocampus was reduced in mice transgenic for a mutated form of amyloid precursor protein 2 that causes early onset familial AD. Ab impaired the proliferation and neuronal differentiation of cultured human and rodent NPC, and promoted apoptosis of neuron-restricted NPC by a mechanism involving dysregulation of cellular calcium homeostasis and the activation of calpains and caspases. Adverse effects of Ab on NPC may contribute to the depletion of neurons and cognitive impairment in AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

Haughey

Nath

Chan

et al. 2002

Journal of Neurochemistry

433

299

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“…The survival, proliferation and development of hematopoietic stem cells (HSCs) in vitro requires the presence of specific growth factors, such as interleukin 3 (IL-3) [233]. ADP receptors were claimed to be present on both human and rat hematopoietic cell lines [234].…”

Section: Hematopoietic Stem Cellsmentioning

confidence: 99%

Purinergic signaling in embryonic and stem cell development

Burnstock

Ulrich

2011

Cell. Mol. Life Sci.

112

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Nucleotides are of crucial importance as carriers of energy in all organisms. However, the concept that in addition to their intracellular roles, nucleotides act as extracellular ligands specifically on receptors of the plasma membrane took longer to be accepted. Purinergic signaling exerted by purines and pyrimidines, principally ATP and adenosine, occurs throughout embryologic development in a wide variety of organisms, including amphibians, birds, and mammals. Cellular signaling, mediated by ATP, is present in development at very early stages, e.g., gastrulation of Xenopus and germ layer definition of chick embryo cells. Purinergic receptor expression and functions have been studied in the development of many organs, including the heart, eye, skeletal muscle and the nervous system. In vitro studies with stem cells revealed that purinergic receptors are involved in the processes of proliferation, differentiation, and phenotype determination of differentiated cells. Thus, nucleotides are able to induce various intracellular signaling pathways via crosstalk with other bioactive molecules acting on growth factor and neurotransmitter receptors. Since normal development is disturbed by dysfunction of purinergic signaling in animal models, further studies are needed to elucidate the functions of purinoceptor subtypes in developmental processes.

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“…We assume that FDC.P2 cells might receive signals leading to Ca 2 + /calcineurin activation at the high concentration of ATP but rapidly die before producing IL-4. In contrast to the cytotoxic activity of ATP, the antiapoptotic effect of ATP has been reported previously for myeloid progenitors and pheochromocytoma cells with no molecular mechanism underlying such effects was elucidated [10,20]. We have elucidated one of the mechanisms underlying such effect of ATP in this study.…”

Section: Discussionmentioning

confidence: 71%

Extracellular ATP inhibits apoptosis and maintains cell viability by inducing autocrine production of interleukin-4 in a myeloid progenitor cell line

Palaga¹,

Kataoka²,

Nagai³

2004

International Immunopharmacology

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Adenosine triphosphate can maintain multipotent haemopoietic stem cells in the absence of interleukin 3 via a membrane permeabilization mechanism

Cited by 14 publications

References 10 publications

Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

Purinergic signaling in embryonic and stem cell development

Extracellular ATP inhibits apoptosis and maintains cell viability by inducing autocrine production of interleukin-4 in a myeloid progenitor cell line

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