Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma

Russo, Cristina; Arcidiacono, G; Polosa, Riccardo

doi:10.1111/j.1472-8206.2005.00388.x

Cited by 29 publications

(23 citation statements)

References 108 publications

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“…Adenosine is an endogenous nucleoside present at low levels under normal conditions; however, its concentrations increase in the setting of stress and inflammation [177]. Adenosine has proinflammatory and immunomodulatory effects and may be involved in the pathogenesis of asthma [178-180].…”

Section: Pathophysiologic Links Between Asthma and Depressionmentioning

confidence: 99%

Psychological Factors in Asthma

Lieshout

MacQueen

2008

All Asth Clin Immun

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Asthma has long been considered a condition in which psychological factors have a role. As in many illnesses, psychological variables may affect outcome in asthma via their effects on treatment adherence and symptom reporting. Emerging evidence suggests that the relation between asthma and psychological factors may be more complex than that, however. Central cognitive processes may influence not only the interpretation of asthma symptoms but also the manifestation of measurable changes in immune and physiologic markers of asthma. Furthermore, asthma and major depressive disorder share several risk factors and have similar patterns of dysregulation in key biologic systems, including the neuroendocrine stress response, cytokines, and neuropeptides. Despite the evidence that depression is common in people with asthma and exerts a negative impact on outcome, few treatment studies have examined whether improving symptoms of depression do, in fact, result in better control of asthma symptoms or improved quality of life in patients with asthma.

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Section: Pathophysiologic Links Between Asthma and Depressionmentioning

confidence: 99%

Psychological Factors in Asthma

Lieshout

MacQueen

2008

All Asth Clin Immun

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“…In fact, level of adenosine in serum, bronchoalveolar lavage (BAL) or exhaled breath condensate (EBC) is significantly greater in asthmatics than in healthy people [6][7][8][9]. Furthermore adenosine concentration increases in nasal lavage fluid and also in EBC is increased in patients with allergic rhinitis [10]. The question however remains what are the benefits (or harms) of high adenosine level in the airways.…”

Section: Introductionmentioning

confidence: 99%

Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases

Vass¹,

Horváth²

2008

CMC

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It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstruction in asthmatic patients, but not in healthy subjects. The mechanism of AMP is indirect and occurs via its decay product, adenosine. It stimulates mast cells through its low-affinity receptor A2B to release histamine, which ultimately leads to smooth muscle contraction. This feature of adenosine reveals its pro-inflammatory function, which may play important role in asthma. Indeed, mice lacking adenosine deaminase (ADA), an enzyme which decomposes adenosine, develop asthma-like disorder with elevated IgE, eosinophilia and airway hyperresponsiveness. Human studies showed elevated adenosine levels in bronchoalveolar lavage and exhaled breath condensate of asthmatics as compared to healthy people. Furthermore, certain human ADA phenotypes are associated with prevalence of asthma. These data suggest a protective role for ADA and a pro-inflammatory function for adenosine in asthma. The role of adenosine in inflammatory processes, however, is not unequivocal. Some in vitro studies showed that adenosine binding to its high-affinity receptor A2A results in inhibition of leukotriene synthesis or function of adhesion molecules. It is possible that the concentration of adenosine in lung tissues determines whether it promotes or reduces inflammation. Adenosine has also been associated with other respiratory diseases such as fibrosis, sarcoidosis, cystic fibrosis or tuberculosis. Identification of adenosine receptor subtypes and their role in the pathomechanism of respiratory diseases may provide new therapeutical targets. This review aims to summarize the role of adenosine and adenosine receptors in asthma and other pulmonary disorders.

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“…The involvement of adenosine in asthma has been the subject of considerable attention over the years, after it was shown that it produced powerful bronchoconstriction in asthma, although it had little effect in healthy lungs; xanthines, antagonists of adenosine receptors, were widely used for treatment of asthma (for reviews, see Persson, 1982;Kawasaki et al, 1983;Holgate et al, 1987Holgate et al, , 1990Feoktistov and Biaggioni, 1996;Fozard and Hannon, 2000;Meade et al, 2001;Fozard and McCarthy, 2002;Holgate, 2002Holgate, , 2005Polosa et al, 2002;Fozard, 2003;Lee et al, 2003;Livingston et al, 2004;Caruso et al, 2006Caruso et al, , 2009Russo et al, 2006;Brown et al, 2008b;Wilson, 2008). It was suggested that the hyper-responsive effects of adenosine in isolated bronchi was due to indirect actions by liberation of histamine and leukotrienes (Björck et al, 1992).…”

Section: A Asthmamentioning

confidence: 99%