2018
DOI: 10.1161/hypertensionaha.117.10765
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Adenosine Receptors Influence Hypertension in Dahl Salt-Sensitive Rats

Abstract: The influence of adenosine receptors on blood pressure in salt-sensitive hypertension is unknown. Here, we examined the effects of salt diets on arterial blood pressures (radiotelemetry) in female and male Dahl salt-sensitive wild-type versus female and male Dahl salt-sensitive A, A, or A receptor knockouts (AKOs, AKOs, and AKOs, respectively). At baseline, all rats were on a 0.3% salt diet; then separate groups were switched to either 4% or 8% salt diet for 2 weeks. Compared with wild-types, baseline pressure… Show more

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Cited by 24 publications
(23 citation statements)
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“…HSDs are an important research topic and are generally recognized to cause hypertension . However, humans continue to consume HSDs.…”
Section: Discussionmentioning
confidence: 99%
“…HSDs are an important research topic and are generally recognized to cause hypertension . However, humans continue to consume HSDs.…”
Section: Discussionmentioning
confidence: 99%
“…This strongly suggests that A 2B -receptor agonists would counteract the vascular remodeling process associated with occlusive disorders in a sex-independent fashion. Nonetheless, as sex differences in adenosine responses are known to occur, 34 in vivo experiments are required to confirm our in vitro findings of sex independence.…”
Section: Hypertensionmentioning
confidence: 67%
“…In fact, KO mice have normal blood pressure [242]. Recently, the deletion of A 2B AR was shown to protect against salt-induced hypertension and stroke [243] and inhibit increases in mean arterial blood pressure [244].…”
Section: A 2b Ar In Cardiovascular Systemsmentioning
confidence: 99%