Adenosine deaminase, dipeptidyl peptidase-IV activities and lipid peroxidation are increased in the saliva of obese young adult

Chielle, Eduardo Ottobelli; Bonfanti, Gabriela; Bona, Karine Santos De; Moresco, Rafael Noal; Moretto, Maria Beatriz

doi:10.1515/cclm-2014-1086

Cited by 16 publications

(15 citation statements)

References 35 publications

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“…This system is composed of antioxidant enzymes (superoxide dismutase, catalase, and many other peroxidases) and nonenzymatic antioxidants, including the glutathione (SH groups), uric acid, ascorbate, and ferric-reducing antioxidant power (FRAP) (13). Was observed a progressive increase TBARS levels in accordance with the increase in body weight and progressive decrease in SH groups and FRAP according to body weight gain (14). The increased oxidative stress in vascular walls is involved in the pathogenesis of atherosclerosis, hypertension and induces damage to cell structures, including membranes, proteins, and ADN and this contributes to disorders cardiometabolic (15).…”

Section: Introductionmentioning

confidence: 97%

Evaluation of salivary oxidative parameters in overweight and obese young adults

Chielle

Casarin

2017

Arch. Endocrinol. Metab.

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Background: Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects. Materials and methods: Levels of lipid peroxidation, ferricreducing antioxidant power, uric acid, and SH groups were determined in the saliva and serum of 149 young adults, including 54 normal weight, 27 overweight, and 68 obese individuals. Anthropometric measurements were also evaluated. Results: Salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, as well as serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation were higher in obese patients when compared with individuals with normal weight. There were correlations between salivary and serum ferric-reducing antioxidant power and salivary and serum uric acid in the obese and normal-weight groups. Conclusions: Our results indicate that the increase in salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, and serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation could be related to the regulation of various processes in the adipose tissue. These findings may hold promise in identifying new oxidative markers to assist in diagnosing and monitoring overweight and obese patients. Arch Endocrinol Metab. 2017;61(2):152-9.

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Section: Introductionmentioning

confidence: 97%

Evaluation of salivary oxidative parameters in overweight and obese young adults

Chielle

Casarin

2017

Arch. Endocrinol. Metab.

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“…Previous work reporting higher DPP-IV activity in the plasma of obese people [8,16] lead to the hypothesis that we may also find higher mouth DPP-IV activity in people that have higher fat masses. In contrast to this hypothesis, fasted salivary DPP-IV was not correlated to body composition.…”

Section: Saliva Dpp-iv Activity Body Composition and Agementioning

confidence: 79%

“…Although we had a range of BMI from 17.5 to 36.3 kg•m -2 , many of the participants in this study were quite lean with an average BMI of 24 ± 4 kg•m -2 , making it possible that this relationship may be stronger in a more obese population. Chielle et al [8] did see an increase in DPP-IV activity in the saliva of obese people compared to normal weight people, but no difference between normal weight and overweight. The majority of our participants were in the normal and overweight category, which may be the reason we did not see the same effect of obesity as Chielle et al [8].…”

Section: Saliva Dpp-iv Activity Body Composition and Agementioning

confidence: 93%

“…Two possible sources of DPP-IV in the mouth are exosomes released by the salivary glands [2,3] and/ or by transport from capillaries or secretion into the gingival cervicular fluid [4]. Although controversial, some research posits that changes in proteins in the saliva may mirror the blood [5][6][7][8]. As a result, salivary DPP-IV may, in part, mirror the plasma activity levels of DPP-IV, especially at resting conditions when the modulation of its hormonal substrates is limited due to homeostatic maintenance.…”

Section: Introductionmentioning

confidence: 99%

“…Studies in humans showed that obese individuals have higher DPP-IV activity [8,16] and lower PYY and NPY levels in the plasma [17,18]. DPP-IV activity is normalized after weight loss via bariatric surgery [16], however, it is not known if these individuals had lifelong high DPP-IV activity or if they developed elevated DPP-IV activity as they gained fat mass.…”

Section: Introductionmentioning

confidence: 99%

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Dipeptidyl Peptidase-IV Activity and Neuropeptide Y in the Mouth: The Relationship with Body Composition and the Impact of Carbohydrates

Neidert

Babu

Kluess

2016

JNB

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Dipeptidyl peptidase-IV (DPP-IV) is an enzyme present in the saliva, and its interaction with satiety related hormones is poorly understood. The purpose of this study was to determine possible relationships between salivary DPP-IV activity and body composition. Further, the response of salivary DPP-IV activity to carbohydrates was investigated. We tested 111 people for plasma and saliva DPP-IV activity using a fluorometric assay and Neuropeptide Y 1-36 (NPY) protein using an EIA. Body composition was determined via a DEXA scan. Relationships were determined using regression analysis. In the second part, we tested 28 people on four separate occasions, where the participants either swished and spit or ingested a commercially available sucrose or aspartame sweetened beverage. Saliva and plasma were collected before and after each condition and were processed as described above. Blood glucose was also measured. No relationship was found between salivary DPP-IV activity or NPY 1-36 and any body composition measurement. For Part 2, no change in plasma DPP-IV occurred with any of the conditions, despite an increase in blood glucose with the sucrose-beverage ingestion condition (p<0.05). However, salivary DPP-IV activity was attenuated with all conditions, except aspartame-beverage swish and spit. Salivary NPY 1-36 was not altered by the conditions. The unique finding from this study was that salivary DPP-IV activity was attenuated with sucrose or aspartame beverage, but plasma DPP-IV was unchanged. This result implies that satiety may be reduced when drinking sucrose or aspartame beverages.

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Adenosine deaminase gene variant in diabetes and obesity

Dayani

Asgarbeik

Asadi

et al. 2022

J Diabetes Metab Disord

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Adenosine deaminase, dipeptidyl peptidase-IV activities and lipid peroxidation are increased in the saliva of obese young adult

Cited by 16 publications

References 35 publications

Evaluation of salivary oxidative parameters in overweight and obese young adults

Evaluation of salivary oxidative parameters in overweight and obese young adults

Dipeptidyl Peptidase-IV Activity and Neuropeptide Y in the Mouth: The Relationship with Body Composition and the Impact of Carbohydrates

Adenosine deaminase gene variant in diabetes and obesity

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