Adenosine Deaminase (ADA) in Tuberculous Meningitis

Skarar, Devendra Nath; Hossain, Ismail; Shoab, Abul Kalam Mohammed; Amin, Robed

doi:10.3329/bjmed.v25i2.25097

Cited by 2 publications

(2 citation statements)

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“…The ADA activity in lymphocytes, especially, T cells, is higher than erythrocytes. Moreover, the activity of this enzyme has some variations during differentiation phases of T-cells and is greater among immature T-cells (7).…”

Section: Introductionmentioning

confidence: 99%

Adenosine Deaminase 1 as a Biomarker for Diagnosis and Monitoring of Patients with Acute Lymphoblastic Leukemia

Ebrahimi‐Rad

Khatami

Ansari

et al. 2018

Journal of Medical Biochemistry

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SummaryBackgroundAcute lymphoblastic leukemia (ALL) is known as the most prevalent pediatric malignancy all around the world. Identification of specific biomarker is necessary for early diagnosis and effective therapy. It is believed that Adenosine deaminase (ADA) as an enzyme involved in the purine salvage pathway increases in ALL patients. Herein, the quantity and pattern of ADA isoenzymes were surveyed among ALL patients in comparison to healthy subjects.MethodsSerum and RBC samples of three different groups of ALL patients, including newly diagnosed cases without any drugs administration, subjects with the relapsed disease, patients in the remission stage after therapy, and the healthy subjects were enrolled in the study. Then, the activity and pattern of ADA1, ADA2 and ADA1+cp were determined using ADA kit and electrophoresis on SDS-PAGE, respectively. To confirm the presence of ADA enzyme, the fresh serums, extractions from erythrocytes, JM cell line as a human T lymphocyte line and J774 A.1 as mouse monocyte line were electrophoresed on 1.2% agarose gel and stained with the specific dye.ResultsThe activities of ADA1 isoenzyme and total ADA in new cases and subjects with the relapsed disease were significantly higher than their activities in the patients in the remission stage and healthy controls (p<0.001). The unbounded ADA1 isoenzyme was found to exist in the erythrocyte, lymphocyte and monocyte. But in serum, all the ADA1 was bounded to the cp protein.ConclusionsADA1 is the key isoenzyme elevating in ALL patients, therefore this isoenzyme could be a useful biomarker to diagnose ALL patients and monitor their therapies.

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Section: Introductionmentioning

confidence: 99%

Adenosine Deaminase 1 as a Biomarker for Diagnosis and Monitoring of Patients with Acute Lymphoblastic Leukemia

Ebrahimi‐Rad

Khatami

Ansari

et al. 2018

Journal of Medical Biochemistry

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“…The enzyme is distributed in all human cells including lymphocytes and monocytes and monocyte-macrophage system is the major source. 2,3 Beside immune system development, ADA acts an important role in differentiation, proliferation, maturation and function of lymphocytes. Aditionally, it is essential for the maturation of blood monocytes to macrophages.…”

Section: Introductionmentioning

confidence: 99%

ADA activity in the follicular fluid of infertile women with diminished ovarian reserve can act as a predictor of ovarian reserve

İlhan¹,

Bacanakgıl²,

Köse³

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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Background: Adenosine deaminase (ADA) catalyses the deamination of adenosine to inosine. In the human reproductive tract, the importance of enzymes that affect metabolism of adenosine, particularly ADA, has been emphasized. It is aimed to evaluate the plasma and follicular fluid (FF) activities of total ADA (ADAT) in infertile women and to determine its relation with ovarian reserve markers and in vitro fertilization (IVF) outcomes.Methods: Plasma and FF activities of ADAT were measured in 106 infertile women. Its relation with ovarian reserve markers and IVF outcomes were determined.Results: There was a significant difference in the ADAT activities between plasma and FF of infertile women (p<0.01). The activity of plasma ADAT was higher than FF ADAT in infertile women (p<0.01). The activity of FF ADAT in DOR group was higher than that of the others (p<0.01). In DOR group; the activity of FF ADAT activity had a negative correlation with BMI and a positive correlation with FSH and no relation with IVF outcomes.Conclusions: Increased ADAT activity can lead to reduced adenosine levels, which might be resulted in disturbed fertility process. The activity of FF ADAT activity might be important for fertility work-up. Further studies are needed.

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Adenosine Deaminase (ADA) in Tuberculous Meningitis

Abstract: not availableBangladesh J Medicine Jul 2014; 25 (2) : 61-71

Cited by 2 publications

References 44 publications

Adenosine Deaminase 1 as a Biomarker for Diagnosis and Monitoring of Patients with Acute Lymphoblastic Leukemia

Adenosine Deaminase 1 as a Biomarker for Diagnosis and Monitoring of Patients with Acute Lymphoblastic Leukemia

ADA activity in the follicular fluid of infertile women with diminished ovarian reserve can act as a predictor of ovarian reserve

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