Adenosine Deaminase Activity in the Serum of Type 2 Diabetic Patients

Abstract

Adenosine deaminase (ADA) is suggested to be an important enzyme for modulating the bioactivity of insulin, but its clinical significance in diabetes mellitus (DM) is not yet characterized. We measured the serum level of ADA in healthy controls (C, n=29) and type 2 diabetic patients (n=42). The mean serum level of ADA in C, and type 2 diabetic patients were 29.81±9.15 and. 20.73±8.42 U/L, respectively (P<0.006 vs. C). ADA levels of patients were significantly correlated with HbA1c (r=0.45, p<0.01). Our findings suggest that ADA may play a role in insulin effect and glycamic control. On the other hand, increased activity of ADA in type 2 DM might be a marker for insulin indication. However, further studies are required for the pathogenic role of elevated ADA activity in type 2 DM.

Effects of resveratrol on nucleotide degrading enzymes in streptozotocin-induced diabetic rats

“…Corroborating with these results, Rutkiewicz and Górski (1990) also found a significant elevation in ADA activity in tissues of diabetic rats induced with STZ. Additionally, studies have suggested that insulin is involved in the regulation of ADA activity in diabetes, and insulin administration is capable of decreasing the elevated activity of this enzyme in these tissues, however the mechanism involved in this phenomenon is unclear at the present time (Rutkiewicz and Górski, 1990;Kurtul et al, 2004;Prakash et al, 2006). Thus, we can suggest that the increase in ADA activity in diabetes could be explained, in part, by insulin action.…”

Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage

“…This indicates severe damage to antioxidant system, which is unable to combat oxidative stress and inflammation [176]. …”

Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase–lowering effects of garlic in patients with type 2 diabetes mellitus with obesity

“…An increase in adenosine deaminase increased serum (S) and tissue adenosine deaminase (ADA) activity is not well known. It is seen that, with higher ADA activity in insulin-sensitive tissues, glucose uptake into cells is reduced;12 thus, if ADA activity is suppressed, insulin sensitivity may be improved and cellular proliferation, inflammation, and T-cell activity (all of which are associated with the pathophysiology of insulin resistance) can be altered. The general consensus is that the main treatment of type 2 diabetes is lifestyle management, like exercise and weight reduction.…”