Adenosine deaminase activity in patients with ovarian neoplasms

Ürünsak, İbrahim Ferhat; Güleç, Ümran Küçükgöz; Paydaş, Semra; Seydaoğlu, Gülşah; Güzel, Ahmet Barış

doi:10.1007/s00404-012-2279-5

Cited by 31 publications

(45 citation statements)

References 22 publications

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“…Several studies investigated the change of the adenosine deaminase activity in various cancerous patients. Many authors have shown the increase of serum tADA activity in these patients (4,7,(23)(24)(25)(26). Adapted to previous data, our results showed higher ADA activity in patients with lung cancer compared to controls.…”

Section: Discussionsupporting

confidence: 85%

“…In an attempt to describe human lung cancer, many studies have concentrated on enzyme activities (3)(4)(5). In addition, some studies established alteration of enzyme activity in bronchoalveolar lavage (6,7). To better understand purine enzymology in lung cancer, more attention has been paid to the investigation of the interrelationship among the carcinogenic process and enzyme activity (de novo and salvage pathways) for purine biosynthesis (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Alteration in serum ADA activity has been reported in a broad range of lung diseases such as tuberculosis and chronic obstructive pulmonary disease (COPD) (10,11). ADA is known as a marker of T-lymphocyte activation (12). ADA levels are found to be increased in effusions related with tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

“…ADA levels are found to be increased in effusions related with tuberculosis. Measurement of ADA in clinical practice is frequently considered as a noninvasive diagnostic test for tuberculosis with 90-100% sensitivity and 89-100% specificity (4,7,13). Furthermore, it has been shown in several studies that ADA activities may be useful both in the diagnosis and monitoring of some malignancies (7,14).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, ADA production by neoplastic cells is increased (4,7) and it could be assumed that respiratory secretions from lung cancer patients may contain high levels of ADA. So far, however, the measurement of ADA in bronchoalveolar lavage (BAL) and bronchial washings has proved unhelpful (16).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Nikkhoo¹,

Sigari²,

Ghaderi³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: This study aimed to determine adenosine deaminase (ADA) activity as a possible screening tool in lung cancer patients. Methods: Blood samples were collected from 30 subjects with positive pathological tests and 62 patients with negative pathological tests as a control group. The enzymatic activity of total ADA and its isoenzymes was determined. Results: tADA and ADA2 isoenzyme activity was significantly higher in cancerous patients compared to benign controls in serum and BAL fluid. Using a cut-off level of respectively 35.22 U/L and 31.80 U/L for BAL total ADA and ADA2, sensitivity and specificity were 100% and 81% for total ADA and 95% and 98% for ADA2. Conclusions: Adenosine deaminase may play important roles in the pathophysiology of lung cancer and because of its

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Nikkhoo¹,

Sigari²,

Ghaderi³

et al. 2013

Journal of Medical Biochemistry

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Interplay between altered metabolism and DNA damage and repair in ovarian cancer

Uboveja,

Aird

2024

BioEssays

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Ovarian cancer is the most lethal gynecological malignancy and is often associated with both DNA repair deficiency and extensive metabolic reprogramming. While still emerging, the interplay between these pathways can affect ovarian cancer phenotypes, including therapeutic resistance to the DNA damaging agents that are standard‐of‐care for this tumor type. In this review, we will discuss what is currently known about cellular metabolic rewiring in ovarian cancer that may impact DNA damage and repair in addition to highlighting how specific DNA repair proteins also promote metabolic changes. We will also discuss relevant data from other cancers that could be used to inform ovarian cancer therapeutic strategies. Changes in the choice of DNA repair mechanism adopted by ovarian cancer are a major factor in promoting therapeutic resistance. Therefore, the impact of metabolic reprogramming on DNA repair mechanisms in ovarian cancer has major clinical implications for targeted combination therapies for the treatment of this devastating disease.

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Ketoprofen-loaded polymeric nanocapsules selectively inhibit cancer cell growth in vitro and in preclinical model of glioblastoma multiforme

et al. 2013

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Glioblastoma multiforme (GBM) is the worst and most common brain tumor, characterized by high proliferation and invasion rates. Nanoparticles of biodegradable polymers for anticancer drug delivery have attracted interest in recent years since they provide targeted delivery and may overcame the obstacle imposed by blood-brain barrier. Here we investigated the antitumoral effect of ketoprofen-loaded nanocapsules (Keto-NC) treatment on in vitro and in vivo glioma progression. We observed that Keto-NC treatment decreased selectively the cell viability of a panel of glioma cell lines, while did not exhibited toxicity to astrocytes. We further demonstrate that the treatment with sub-therapeutic dose of Keto-NC reduced the in vivo glioma growth as well as reduced the malignity characteristics of implanted tumors. Keto-NC treatment improved the weight, the locomotion/exploration behavior of glioma-bearing rats. Importantly, Keto-NC treatment neither induced mortality or peripheral damage. Finally, Ketoprofen also altered the extracellular nucleotide metabolism of peripheral lymphocytes, suggesting that antiinflammatory effects of ketoprofen could also be associated with the modulation of the adenine nucleotide metabolism in lymphocytes. Data indicate at first time the potential of Keto-NC as a promising therapeutic alterative to GBM treatment.

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Adenosine deaminase activity in patients with ovarian neoplasms

Abstract: Serum and peritoneal fluid ADA levels were found to be higher in malignant ovarian neoplasms. This finding may be useful to understand the biochemically characteristics of malignant ovarian tumors and ADA may be a useful biomarker in diagnosis and management of ovarian tumors.

Cited by 31 publications

References 22 publications

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Interplay between altered metabolism and DNA damage and repair in ovarian cancer

Ketoprofen-loaded polymeric nanocapsules selectively inhibit cancer cell growth in vitro and in preclinical model of glioblastoma multiforme

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