Adenosine and the Cardiovascular System

Reiss, Allison B.; Grossfeld, David; Kasselman, Lora J.; Renna, Heather A.; Vernice, Nicholas A.; Drewes, Wendy; Konig, Justin; Carsons, Steven E.; DeLeon, Joshua

doi:10.1007/s40256-019-00345-5

Cited by 84 publications

(76 citation statements)

References 207 publications

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“…Along with being cardioprotective via inhibition of the inflammatory response, A 2A AR agonists (PSB-15826, PSB-12404, and PSB-16301) also modulate platelet aggregation [186], and ATL313 regulates cholesterol homeostasis [187]. Perhaps the pharmaceutical industry will focus on the anti-inflammatory effects of A 2A AR agonists against excess cholesterol accumulation to develop new cardiovascular therapies [188]. A2A receptor agonists are the focus of efforts by the pharmaceutical industry to develop new cardiovascular therapies, and pharmacological actions of the atheroprotective and anti-inflammatory drug methotrexate are mediated via release of adenosine and activation of the A2A receptor.…”

Section: A 2a Ar In the Cardiovascular Systemsmentioning

confidence: 99%

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Effendi

Nagano

Kobayashi

et al. 2020

Cells

117

103

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Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as A1AR, A2AAR, A2BAR, and A3AR, which are the center of cAMP signal pathway-based drug development. Several types of agonists, partial agonists or antagonists, and allosteric substances have been synthesized from these receptors as new therapeutic drug candidates. Research efforts surrounding A1AR and A2AAR are perhaps the most enticing because of their concentration and affinity; however, as a consequence of distressing conditions, both A2BAR and A3AR levels might accumulate. This review focuses on the biological features of each adenosine receptor as the basis of ligand production and describes clinical studies of adenosine receptor-associated pharmaceuticals in human diseases.

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Section: A 2a Ar In the Cardiovascular Systemsmentioning

confidence: 99%

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Effendi

Nagano

Kobayashi

et al. 2020

Cells

117

103

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“…Vasoconstrictor mediators (endothelin, adenosine, angiotensin II, vasopressin) are known to play a key role CIN and CVD pathogenesis [65,[69][70][71][72][73] . CM is known to cause immediate vasoconstriction and vasodilation impairment, reduce renal blood flow, decrease glomerular filtration rate (GFR) and cause renal hypoperfusion, which leads to an inadequate delivery of oxygen, promoting ischemic injury [ Figure 1].…”

Section: Cin Pathophysiology In the Context Of Cvdmentioning

confidence: 99%

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Cervantes-Gracia

Raja²,

Llanas-Cornejo

et al. 2020

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Utilization of contrast media to visualize vasculature structures in the setting of cardiovascular disorders (CVD) can lead to acute kidney injury, referred to as contrast-induced nephropathy (CIN). CIN can potentiate mortality and hospitalization in aged individuals, patients with CVD, nephropathy, enhancing kidney damage, and cardiac events. Preventing CIN by identifying risk factors is important. The underlying mechanisms of CIN pathology are unclear, but the key factors include direct cytotoxicity, oxidative stress, vascular and endothelial dysfunction and inflammatory processes. Reactive Oxygen Species and inflammatory mediators have been proposed as key factors influencing the development of CIN and CVD, and the elucidation of the interplay between the mechanisms evoked by them may provide a better understanding of the signaling processes happening in these conditions, thereby potentially enabling early identification, prevention and characterization of novel drug targets.

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“…The effects of one of the CRS compounds could explain the hemorrhage scores and increased incisional bleeding observed in group C. The purine nucleoside adenosine, a potent vasodilator in almost all vascular beds, occupies a unique position in the regulation of microcirculation, inflammatory response, and neurogenic activity in the gut. Adenosine participates in the control of vascular tone (Rubino et al, 1995) and is a potent inhibitor of platelet aggregation and inflammatory response (Reiss et al, 2019). In addition, adenosine infusion increases blood flow to the gastrointestinal tract (Pennanen et al, 1994), and may have neuroprotective effects (Seydyousefi et al, 2019).…”

Section: Arq Bras Med Vet Zootecmentioning

confidence: 99%

Brief topical and intraluminal use of Carolina rinse solution does not attenuate experimental ischemia and reperfusion injury in rabbit jejunum

Brandstetter

Pedroso

Oliveira

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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Fifteen New Zealand adult rabbits were randomly allocated into three groups: Sham-operated (group A), Ischemia and Reperfusion (group B) and Carolina Rinse Solution (CRS) (group C). Groups B and C were subjected to one hour of ischemia and two hours of reperfusion. In group C, ten minutes before reperfusion, the bowel lumen was filled with CRS, and the segment immersed in CRS. Necrosis and loss of integrity of the villi were visible in groups B and C. Edema of the submucosa and circular muscle was observed in all groups. Hemorrhage was observed in different layers for groups B and C, but group C showed more severe hemorrhage in different layers during reperfusion. All groups showed polymorphonuclear leukocyte infiltration on the base of the mucosa, submucosa, and longitudinal muscle, in addition to polymorphonuclear leukocytes margination in the mucosal and submucosal vessels. Necrosis of enterocytes, muscles, crypts of Lieberkühn and myenteric plexus was observed in groups B and C during reperfusion. Topical and intraluminal Carolina Rinse Solution did not attenuate the effects of ischemia and reperfusion in the small intestine of rabbits.

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Adenosine and the Cardiovascular System

Cited by 84 publications

References 207 publications

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Brief topical and intraluminal use of Carolina rinse solution does not attenuate experimental ischemia and reperfusion injury in rabbit jejunum

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