Adenosine adducts with first row transition metal perchlorates

Can nucleotides prevent Cu-induced oxidative damage?

“…Coordination of Cu(II) with adenosine involves N1 and (or) N7, resulting in polymeric structures in which Cu(II) is tetra-coordinated [54]. However, Cu(I) coordinates preferentially with soft donors (e.g.…”

5?-Deoxyadenosine complexes with chromium(III) and iron(III) perchlorates

“…Unlike ado and 2'-dado, which have so far been found only to form exclusively adducts with 3d metal salts (2)(3)(4), 5'-deoxyadenosine gives complexes formed by substitution of three monoanionic L-ligands for three C10~ groups per two metal ions. Monodeprotonation of the exocyclic NH2 group of nucleobases, such as adenine and cytosine, and their nucleosides is not generally facile (8), but can (reportedly) occur in some cases, e.g.…”

“…complexes in which the ligands remain formally neutral) with first row transition metal halides or perchlorates (2)(3)(4). Recently, we extended our studies to include complexes with 5'-deoxyadenosine [dado; LH; (1)], which had previously been investigated as a ligand only in 5'-deoxyadenosylcobaloxime complexes ~5'6).…”

Interaction of adenosine, guanosine and inosine with ruthenium hydride complexes

“…In ADS, the ribose substituent blocks the N(9) site so that when ADS acts as a unidentate ligand it binds through the N(7) atom while N(1) and N(7) atoms are used for bidentate binding. 15 N(3) is not a probable coordinating site because of the steric hinderance created by the ribose group. 16 Thus the probable sites of metal ion binding are N(1), N(7) and C 6 -NH 2 in ADS.…”

“…The NH 2 band appearing at 1670 cm -1 in the spectrum of ADS undergoes substantial shifts towards lower frequency (1630 cm -1 ) in the complex, showing coordination through the C 6 -NH 2 group of ADS because the NH 2 band shows a higher frequency shift on hydrogen bonding. 15 The NH 2 the spectrum of the complex.…”