Adenosine A1 and A2a receptors modulate the nitrergic system in cell culture from dorsomedial medulla oblongata

Costa, Maisa Aparecida; Matsumoto, J P P; Carrettiero, Daniel Carneiro; Fior-Chadi, Débora Rejane

doi:10.1016/j.autneu.2020.102737

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Some studies showed a positive outcome on contractility 22 or stated it affects beta-receptors as well 23 , while others claim it has an indirect effect on contractility but no beta-receptor activity 24 . Apart from a direct reaction on the myocardium, recent reports focused on its repercussions in the central nervous system (CNS), mainly in the nucleus tractus solitarius but other parts of CNS as well 25 , and its possible influence on baroreflex via CNS 26 . However, most of the studies were on rats or mice models or isolated myocardial cells, and for example, the effect on baroreflex could be indirect via hypotension from vasodilatation resulting in increasing HR and contractility of the myocardium.…”

Section: Discussionmentioning

confidence: 99%

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

Opatřil

Panovský

Mojica-Pisciotti

et al. 2022

Sci Rep

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Rest pulmonary circulation parameters such as pulmonary transit time (PTT), heart rate corrected PTT (PTTc) and pulmonary transit beats (PTB) can be evaluated using several methods, including the first-pass perfusion from cardiovascular magnetic resonance. As previously published, up to 58% of patients after HTx have diastolic dysfunction detectable only in stress conditions. By using adenosine stress perfusion images, stress analogues of the mentioned parameters can be assessed. By dividing stress to rest biomarkers, potential new ratio parameters (PTT ratio and PTTc ratio) can be obtained. The objectives were to (1) provide more evidence about stress pulmonary circulation biomarkers, (2) present stress to rest ratio parameters, and (3) assess these biomarkers in patients with presumed diastolic dysfunction after heart transplant (HTx) and in childhood cancer survivors (CCS) without any signs of diastolic dysfunction. In this retrospective study, 48 patients after HTx, divided into subgroups based on echocardiographic signs of diastolic dysfunction (41 without, 7 with) and 39 CCS were enrolled. PTT was defined as the difference between the onset time of the signal intensity increase in the left and the right ventricle. PTT in rest conditions were without significant differences when comparing the CCS and HTx subgroup without diastolic dysfunction (4.96 ± 0.93 s vs. 5.51 ± 1.14 s, p = 0.063) or with diastolic dysfunction (4.96 ± 0.93 s vs. 6.04 ± 1.13 s, p = 0.13). However, in stress conditions, both PTT and PTTc were significantly lower in the CCS group than in the HTx subgroups, (PTT: 3.76 ± 0.78 s vs. 4.82 ± 1.03 s, p < 0.001; 5.52 ± 1.56 s, p = 0.002). PTT ratio and PTTc ratio were below 1 in all groups. In conclusion, stress pulmonary circulation parameters obtained from CMR showed prolonged PTT and PTTc in HTx groups compared to CCS, which corresponds with the presumption of underlying diastolic dysfunction. The ratio parameters were less than 1.

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Section: Discussionmentioning

confidence: 99%

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

Opatřil

Panovský

Mojica-Pisciotti

et al. 2022

Sci Rep

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“… 37 , 38 Other articles then outline a direct effect on increasing contractility 39 and even on the central nervous system. 40 , 41 These facts and different results show that more data and studies are needed on this compelling topic.…”

Section: Current State Of the Artmentioning

confidence: 99%

Stress and Rest Pulmonary Transit Times Assessed by Cardiovascular Magnetic Resonance

Opatřil

Panovský

Mojica-Pisciotti

et al. 2022

Cardiology in Review

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Acquiring pulmonary circulation parameters as a potential marker of cardiopulmonary function is not new. Methods to obtain these parameters have been developed over time, with the latest being first-pass perfusion sequences in cardiovascular magnetic resonance (CMR). Even though more data on these parameters has been recently published, different nomenclature and acquisition methods are used across studies; some works even reported conflicting data. The most commonly used circulation parameters obtained using CMR include pulmonary transit time (PTT) and pulmonary transit beats (PTB). PTT is the time needed for a contrast agent (typically gadolinium-based) to circulate from the right ventricle (RV) to the left ventricle (LV). PTB is the number of cardiac cycles the process takes. Some authors also include corrected heart rate (HR) versions along with standard PTT. Besides other methods, CMR offers an option to assess stress circulation parameters, but data are minimal. This review aims to summarize the up-to-date findings and provide an overview of the latest progress on this promising, dynamically evolving topic.

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Adenosine A1 and A2a receptors modulate the nitrergic system in cell culture from dorsomedial medulla oblongata

Cited by 2 publications

References 27 publications

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

Stress and Rest Pulmonary Transit Times Assessed by Cardiovascular Magnetic Resonance

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