Adenosina y control homeostático del sueño. Acciones en estructuras diana de los circuitos de vigilia y sueño

Carús-Cadavieco, Marta; Andrés, Isabel de

doi:10.33588/rn.5507.2012258

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…El sueño es impulsado por el aumento secuencial de la adenosina y el óxido nítrico durante la vigilia (22). La adenosina es un producto del metabolismo del ATP de N y neuroglia; y ejerce control homeostático sobre el circuito S/V (41).…”

Section: Fisiología Del Sueñounclassified

El sueño: fisiología y homeostasis

Padilla-Gil

2023

Rev Colombiana Cienc Anim. RECIA

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Todos los animales disponen de mecanismos fisiológicos y homeostáticos para generar, mantener, ajustar y sincronizar los ciclos endógenos/exógenos del sueño. Varias áreas del cerebro intervienen en la activación y regulación de los ciclos sueño/vigilia y su sincronía con el ciclo luz/oscuridad. Toda esta actividad fisiológica está incluida en el reloj biológico (o ritmo circadiano) de cada animal, el cual está modulado por genes, proteínas, y neurotransmisores. El sueño se relaciona con los procesos de recuperación o reparación, mantenimiento y restauración de la eficacia de todos los sistemas del organismo, principalmente de los sistemas nervioso, endocrino e inmunológico. Dada la importancia del sueño tanto para los animales como para los humanos, esta revisión presenta una reseña sobre la fisiología y homeostasis del sueño, documentada a través de bibliografía científica publicada en los últimos cinco años (2017-2022), en revistas científicas como Science y Nature, de las bases de datos PubMed, Science Direct, o clasificadas en Scimago. El sueño está regulado por factores exógenos y endógenos, en estos últimos son actores principales los neurotransmisores (serotonina, histamina), neuromoduladores (noradrenalina), hormonas (sistema orexina/hipocretina, melatonina), el sistema glinfático y los genes que activan las diferentes vías de señalización para que funcione en forma óptima las neuronas y la glía del encéfalo.

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Section: Fisiología Del Sueñounclassified

El sueño: fisiología y homeostasis

Padilla-Gil

2023

Rev Colombiana Cienc Anim. RECIA

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“…Considered an important nucleoside, Ado is formed by the binding of an adenine to a ribose, which can be formed by the hydrolysis of ATP, by the cleavage of S-adenosyl-homocysteine [43] or by the action of the 5'-nucleotidase enzyme in degrading AMP [44] . Regardless of the origin, Ado can be present in the intra and extracellular environment, acting fundamentally in the regulation of homeostasis and as a neuromodulator, as mentioned by Cunha [45] , and may be involved in the regulation of sleep [46] , [47] , cognition, and memory [48] , [49] , [50] .…”

Section: Purinergic Systemmentioning

confidence: 99%

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

Simões

Basso

Kosvoski

et al. 2021

International Immunopharmacology

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The etiological agent of coronavirus disease (COVID-19) is the new member of the Coronaviridae family, a severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2), responsible for the pandemic that is plaguing the world. The single-stranded RNA virus is capable of infecting the respiratory tract, by binding the spike (S) protein on its viral surface to receptors for the angiotensin II-converting enzyme (ACE2), highly expressed in the pulmonary tissue, enabling the interaction of the virus with alveolar epithelial cells promoting endocytosis and replication of viral material. The infection triggers the activation of the immune system, increased purinergic signaling, and the release of cytokines as a defense mechanism, but the response can become exaggerated and prompt the so-called “cytokine storm”, developing cases such as severe acute respiratory syndrome (SARS). This is characterized by fever, cough, and difficulty breathing, which can progress to pneumonia, failure of different organs and death. Thus, the present review aims to compile and correlate the mechanisms involved between the immune and purinergic systems with COVID-19, since the modulation of purinergic receptors, such as A2A, A2B, and P2X7 expressed by immune cells, seems to be effective as a promising therapy, to reduce the severity of the disease, as well as aid in the treatment of acute lung diseases and other cases of generalized inflammation.

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“…It is known that adenosine signaling has a neuromodulatory role, which is involved in the regulation of important mechanisms in the CNS, such as anxiety states (Csölle et al, 2013), sleep (Huang et al, 2011;Carús-Cadavieco and de Andrés, 2012), motor function, cognition and memory (Salamone and Correa, 2009;Shen et al, 2012;Wei et al, 2011), among others. Adenosine receptors have been subdivided into four subtypes: A 1 , A 2A , A 2B , and A 3 .…”

Section: Introductionmentioning

confidence: 99%