Adénose sclérosante polykystique de la parotide : diagnostic et prise en charge thérapeutique

Perottino, Flavio; Barnoud, R; Ambrun, A.; Poupart, M.; Pignat, J.-C.; Merrot, O.

doi:10.1016/j.aforl.2010.02.005

Cited by 1 publication

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“…An important feature found in SPA cases is intraductal epithelial proliferations associated with cellular atypia, that range from mild to invasive carcinoma. [2][3][4]7,9,10,12,14,16,17,21,23,[34][35][36][37][38][39][40] The presence of these cellular alterations combined with molecular alterations leads to some authors' conclusion that SPAs are neoplasms rather than reactive inflammatory lesions and should be referred to as sclerosing polycystic adenoma. 9,10 All patients described in previous reports received different forms of treatment including conservative surgery was the most common form of treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review

et al. 2023

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In this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched to access cases of SPA in salivary glands. One hundred and thirty cases of SPA were found across 61 selected articles. SPA affected mainly the parotid gland of adults with a mean age of 44.6 years old, with a slight preference for females. The lesion was usually presented as a painless firm mass with a long period of evolution. Histologically, they are well‐delimitated lesions composed of acinar and ductal elements with a variety of cytomorphologic features surrounded by a densely collagenized stroma. PI3K was the most common gene mutation related to SPA. SPA is a benign condition that mainly affects the parotid gland of female patients and it is usually treated by surgical resection with a good prognosis.

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