Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome

Parker, Garrett; Miladi, Anis; Thomas, Brian C.

doi:10.5070/d35bv169fz

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…To date, 20 cases of AESOP syndrome have been published, including ours (Table 1). 3–6,8–17 In all cases, patients presented with an extensive ill-defined violaceous patch on the trunk, in 19 an underlying plasmacytoma was identified, and in 1 case it was a blue-cell sarcoma. 10,15 The most common location of the plasmacytoma was ribs (10/19), followed by sternum (5/19), scapula (1/19), clavicle (1/19), skull (1/19), and cervical spine/ribs (1/19).…”

Section: Discussionmentioning

confidence: 99%

“…7 To date, 20 cases of AESOP syndrome have been published, including ours (Table 1). [3][4][5][6][8][9][10][11][12][13][14][15][16][17] In all cases, patients presented with an extensive ill-defined violaceous patch on the trunk, in 19 an underlying plasmacytoma was identified, and in 1 case it was a blue-cell sarcoma. ).…”

Section: Discussionmentioning

confidence: 99%

“…endocrinopathy) and cure rates are higher. [3][4][5] Therefore, timely recognition of AESOP is important. To date, only 17 cases of AESOP have been published as either a single patient case report or small case series.…”

Section: Introductionmentioning

confidence: 99%

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Adenopathy and extensive skin patch overlying plasmacytoma syndrome—the clue to early diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes: A case series and literature review

Sanchez

Ramos

Ratnarajah

et al. 2022

SAGE Open Medical Case Reports

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Importance: Adenopathy and extensive skin patch overlying plasmacytoma syndrome is a paraneoplastic syndrome characterized by a cutaneous vascular patch overlying a plasmacytoma and systemic manifestations. It is thought to be an early stage of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome, which is a rare, but potentially fatal multisystemic disease that is associated with plasma cell dyscrasia. Thus, a high index of suspicion is required to identify patients with adenopathy and extensive skin patch overlying plasmacytoma as they may present with early polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes, which is curable if detected early. Objective: To report additional cases of adenopathy and extensive skin patch overlying plasmacytoma syndrome, describe dermatoscopic and histologic findings of the cutaneous patch and review all up to date literature on adenopathy and extensive skin patch overlying plasmacytoma syndrome. Design: Case series from a single tertiary care center. Participants: Here, we present the second case series of three patients with adenopathy and extensive skin patch overlying plasmacytoma syndrome who all meet the diagnostic criteria for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. The diagnosis was suspected based on the presence of the violaceous cutaneous patch along with symptoms of systemic involvement (fatigue, weight loss, weakness). Dermoscopy revealing regular dilated parallel capillaries was suggestive of a benign/reactive vascular process. Histopathology in all three cases showed reactive vascular proliferation with a characteristic 90° branching. To date only 20 cases of adenopathy and extensive skin patch overlying plasmacytoma have been published, including ours. All patients presented with cutaneous lesions (violaceous patch and others) and most, at least 15/20, met the diagnostic criteria for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. When clinical follow-up was reported, most patients had a favorable prognosis with partial or complete symptom resolution following treatment of the underlying plasmocytoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adenopathy and extensive skin patch overlying plasmacytoma syndrome—the clue to early diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes: A case series and literature review

Sanchez

Ramos

Ratnarajah

et al. 2022

SAGE Open Medical Case Reports

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AESOP syndrome: a potential life-saving and early clue to the diagnosis of POEMS syndrome

Lenormand

Marzolf

Lipsker

2021

Clinics in Dermatology

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Skin manifestations of POEMS and AESOP syndrome in the same patient revealing plasma cell dyscrasia

et al. 2016

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POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin signs) and AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) syndromes are rare paraneoplastic conditions due to an underlying plasma cell dyscrasia. We report a 70-year-old patient with the rare coexistence of POEMS and AESOP syndromes and in whom skin signs, that differ both clinically and histologically, were the clues to the diagnosis of a plasma cell disorder. Vascular endothelial growth factor-A overexpression seems to be the common pathogenetic link of the different clinicopathological presentations of the skin lesions.

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Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome

Cited by 4 publications

References 10 publications

Adenopathy and extensive skin patch overlying plasmacytoma syndrome—the clue to early diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes: A case series and literature review

Adenopathy and extensive skin patch overlying plasmacytoma syndrome—the clue to early diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes: A case series and literature review

AESOP syndrome: a potential life-saving and early clue to the diagnosis of POEMS syndrome

Skin manifestations of POEMS and AESOP syndrome in the same patient revealing plasma cell dyscrasia

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