Adenomyosis reduces pregnancy rates in infertile women undergoing IVF

Salim, Rehan; Riris, Solon; Saab, Wael; Abramov, Benjamin; Khadum, Iffat; Serhal, Paul

doi:10.1016/j.rbmo.2012.05.003

Cited by 102 publications

(133 citation statements)

References 19 publications

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“…Our observation is in line with five previous studies on this subject (Chiang et al, 1999;Costello et al, 2011;Martínez-Conejero et al, 2011;Mijatovic et al, 2010;Salim et al, 2012) and, in contrast with the remaining four (Ballester et al, 2012;Maubon et al, 2010;Thalluri and Tremellen, 2012;Youm et al, 2011). Our study has some important strengths compared with the previous available contributions.…”

Section: Discussionsupporting

confidence: 92%

“…Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies (Vercellini et al, 2014). Of particular relevance here is that only four studies were prospective (Ballester et al, 2012;Chiang et al, 1999;Maubon et al, 2010;Salim et al, 2012), and that reported data were seldom adjusted for age, ovarian responsiveness and embryo quality (Ballester et al, 2012;Costello et al, 2011;Thalluri and Tremellen, 2012), three pivotal confounders when focusing on embryo implantation.…”

Section: Introductionmentioning

confidence: 97%

“…To the best of our knowledge, nine original studies have been published using this study design, most of them during the past 3 years (Ballester et al, 2012;Chiang et al, 1999;Costello et al, 2011;Martínez-Conejero et al, 2011;Maubon et al, 2010;Mijatovic et al, 2010;Salim et al, 2012;Thalluri and Tremellen, 2012;Youm et al, 2011). Results from these contributions, however, are conflicting, with four of them suggesting an association (Ballester et al, 2012;Maubon et al, 2010;Thalluri and Tremellen, 2012;Youm et al, 2011) and five failing to document any statistically significant effect (Chiang et al, 1999;Costello et al, 2011;Martínez-Conejero et al, 2011;Mijatovic et al, 2010;Salim et al, 2012). Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies (Vercellini et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Asymptomatic adenomyosis and embryo implantation in IVF cycles

Benaglia

Cardellicchio

Leonardi

et al. 2014

Reproductive BioMedicine Online

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Research on the effect of adenomyosis on the rate of success of IVF is controversial. Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies. To establish whether embryo implantation is impaired in women with adenomyosis, women scheduled for IVF were prospectively evaluated for the presence of adenomyosis and whether this condition affected embryo implantation. Forty-nine women with adenomyosis diagnosed at transvaginal ultrasound with no abnormal uterine bleeding were recruited. They were matched for study period, age, day of embryo transfer and number of transferred embryos to 49 controls without the disease. In women with adenomyosis, 24 out of 76 embryos transferred implanted (32%); this occurred in 16 out of 76 (21%) in unaffected controls. The crude odds ratio of implantation in affected women was 1.73 (95% CI 0.83 to 3.60). The odds ratio adjusted for body mass index (the unique variable found to differ at univariate analysis) was 1.78 (95% CI 0.85 to 3.77). In conclusion, implantation rate is not impaired in asymptomatic women who are diagnosed with adenomyosis at transvaginal sonography. Affected women can be reassured about the effect of this condition on their chances of success.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Asymptomatic adenomyosis and embryo implantation in IVF cycles

Benaglia

Cardellicchio

Leonardi

et al. 2014

Reproductive BioMedicine Online

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“…Recently, reports have focused on the relationship between adenomyosis and infertility, but with controversial conclusions and no consensus. Salim et al [2] reported that the clinical pregnancy rate (CPR) and ongoing pregnancy rate were significantly lower, and the miscarriage rate significantly higher, in 19 women with adenomyosis versus 256 women without adenomyosis. Costello et al [3 ]reported that the presence of adenomyosis did not adversely affect the outcome in women undergoing in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of Adenomyosis on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Retrospective Cohort Study

Yan

Ding

Tang

et al. 2013

Gynecol Obstet Invest

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Aims: To study the effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile patients. Methods: We performed a retrospective, database-searched cohort study based on 10,268 patients undergoing controlled ovarian hyperstimulation and IVF/ICSI between 2009 and 2011 in our unit. Adenomyosis was diagnosed by transvaginal ultrasound. A high-quality matched cohort study with strict inclusion criteria was conducted. We compared the basic characteristics and main IVF/ICSI outcomes between the two groups. Results: We identified 83 patients with adenomyosis, of whom we included 77, and strictly matched them to 77 patients without adenomyosis. Higher day 3 estrogen levels and a longer duration of gonadotropin stimulation days were found in women with adenomyosis compared to control subjects. Patients with adenomyosis had a nonsignificant trend toward a lower clinical pregnancy rate and a higher miscarriage rate (p = 0.103 and 0.09, respectively). The delivery rate was significantly lower in the adenomyosis group in comparison to the matched controls (p = 0.022). Conclusions: Within the limitations of a retrospective study (albeit with a remarkably large number of observations), our results suggest that transvaginal ultrasound-diagnosed adenomyosis could have a negative impact on the main IVF/ICSI outcomes. Improving the diagnostic validity and scoring of disease severity in patients with adenomyosis is suggested.

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“…117 Another small study of 19 women with adenomyosis and 256 controls, also found lower ongoing pregnancy and higher miscarriage rates. 118 …”

Section: Adenomyosismentioning

confidence: 99%