Adénomes hypophysaires à TSH ou adénomes thyréotropes

Caron, Philippe

doi:10.1016/j.lpm.2008.09.015

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…These diagnoses can be easily excluded by questioning, monitoring of drug intake, testing malabsorption, and repeating serum TSH measurement with several laboratory methods to exclude transitory changes and biological interference [ 15 , 16 ]. Once these diagnoses are excluded, we are therefore faced with SITSH and the second step is to differentiate between TSHoma and syndromes of thyroid hormone resistance (RTH) [ 16 , 17 ]. The differential diagnosis is complicated, so clinical presentations, laboratory assessment, and imaging advances may help and guide diagnosis ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma

Safi

Benabdelfedil

Derrou

et al. 2021

Case Reports in Endocrinology

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Background. The thyrotropin-secreting adenomas are very rare and even more rare when they simultaneously coexist with thyroid carcinoma. So far, only sixteen cases have been reported in the literature. Here, we present a unique case of successful management of a concurrent case of thyrotropin-prolactinoma with papillary thyroid carcinoma. Case Presentation. A 50-year-old Moroccan woman underwent a total thyroidectomy and complementary totalization by iratherapy for papillary thyroid carcinoma, who presented persistence of an inappropriate secretion of the thyroid-stimulating hormone (TSH > 4 mUI/L) despite of levothyroxine suppressive therapy (300 μg/d). After eliminating noncompliance, interfering medicines, and thyroid malabsorption, a pituitary adenoma (12 mm) was documented at magnetic resonance imaging. The patient has had transsphenoidal pituitary adenomectomy with histology confirming a thyrotropin-prolactin-secreting adenoma. After surgery and lanreotide treatment failures, we noted a complete response (TSH < 0.5) with cabergoline treatment (3 mg/week). Conclusion. The unusual association of thyroid adenocarcinoma and TSHoma enriches the hypothesis of a potential link between thyrotropic hypersecretion and thyroid carcinogenesis. Our case also illustrates the difficulty of monitoring thyroid carcinoma in nonremission of a TSHoma.

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Section: Discussionmentioning

confidence: 99%

Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma

Safi

Benabdelfedil

Derrou

et al. 2021

Case Reports in Endocrinology

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Présentation et pronostic des adénomes thyréotropes : à propos de trois observations

Latrech

Rousseau

Marois

et al. 2010

La Revue de Médecine Interne

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Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review

Anyfantakis

Vourliotaki

2016

Case Reports in Endocrinology

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Resistance to thyroid hormone (RTH) is an extremely rare dominantly inherited condition of impaired tissue responsiveness to thyroid hormone (TH). Most patients with RTH have mutations in the gene that encodes the β isoform of the receptor of thyroid hormone (THR-β gene). Mutant receptors are unable to activate or repress target genes. The majority of them are asymptomatic or rarely have hypo- or hyperthyroidism. RTH is suspected by the finding of persistent elevation of serum levels of free T3 (FT3) and free T4 (FT4) and nonsuppressed TSH. We present two cases of RTH diagnosed after total thyroidectomy. The first patient was initially diagnosed with primary hyperthyroidism due to toxic multinodular goiter. The second patient had undergone thyroidectomy for multinodular goiter 16 years before diagnosis of RTH. After thyroidectomy, although on relatively high doses of levothyroxine, both of them presented with the laboratory findings of RTH. Genetic analysis revealed RTH.

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Adénomes hypophysaires à TSH ou adénomes thyréotropes

Cited by 3 publications

References 26 publications

Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma

Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma

Présentation et pronostic des adénomes thyréotropes : à propos de trois observations

Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review

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