Adenomatoid tumor of the right adrenal gland in a patient with AIDS

Ángeles-Ángeles, Arturo; Reyes, Edgardo; Muñoz-Fernández, Luis; Angritt, Peter

doi:10.1007/bf02739708

Cited by 22 publications

(13 citation statements)

References 12 publications

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“…AT of the adrenal gland is extremely rare. This tumor has only recently been recognized, with only 26 cases in the literature to date 8–24 . The clinicopathological features of 27 cases of adrenal AT, including the present case, are as follows.…”

Section: Discussionmentioning

confidence: 80%

“…Extragenital AT have been reported to occur in the omentum, 1 umbilical skin, 2 the mesentery of the small intestine, 3 pancreas, 4 mediastinal lymph node, 5 pleura, 6 and heart 7 . Adrenal AT have been recently recognized and 26 cases were reported with marked male predominance 8–24 . We herein report an autopsy case of adrenal AT with acute coronary thrombosis resulting in heart failure, and examine the tumor immunohistochemically with reference to sex hormone receptors, and discuss its histogenesis.…”

mentioning

confidence: 92%

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Adenomatoid tumor of the adrenal gland: Case report with immunohistochemical study

Hamamatsu

Arai

Iwamoto

et al. 2005

Pathology International

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Adrenal adenomatoid tumor (AT) is a recently recognized disease with marked male predominance. Herein is presented a case of adrenal AT incidentally found in a 30-year-old man and results of immunohistochemical examination of the tumor. The left adrenal gland, weighing 17 g, contained a mass measuring 3 x 2.5 x 2.5 cm in the cortical tissue. Cut surface showed a relatively well-circumscribed firm tumor with a white solid appearance. Histologically, the tumor had the typical appearance of AT described in the genital tract. Immunohistochemically, the tumor cells were positive for calretinin, D2-40, WT1, mesothelial cell antigen, CA125, thrombomodulin, vimentin and cytokeratins (stained by AE1 + AE3, OV-TL 12/30, CAM5.2 and MNF116), and negative for endothelial markers (CD31, CD34 and factor VIII-related antigen) and CD56. CD56-positive adrenocortical cells were diffusely scattered in the tumor, especially in its periphery. Immunohistochemistry of estrogen, progesterone and androgen receptors was negative. These findings confirm mesothelial origin of the tumor and suggest that this tumor has little relation to sex hormone despite male predominance.

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Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 92%

Adenomatoid tumor of the adrenal gland: Case report with immunohistochemical study

Hamamatsu

Arai

Iwamoto

et al. 2005

Pathology International

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“…The pathogenesis of adenomatoid tumor remains unknown. However, an increased incidence of this tumor is noticed in patients undergoing iatrogenic immunosuppression 57‐61 or with chronic viral infection 28,47,62 …”

Section: Discussionmentioning

confidence: 99%

Adenomatoid tumor of the skin: Differential diagnosis of an umbilical erythematous plaque

et al. 2020

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Adenomatoid tumors are benign tumors of mesothelial origin that are usually encountered in the genital tract. Although they have been observed in other organs, the skin appears to be a very rare location, with only one case reported in the literature to our knowledge. We report a second case of an adenomatoid tumor, arising in the umbilicus of a 44-year-old woman. The patient presented with an 8-month-old erythematous and firm plaque under the umbilicus. A skin biopsy showed numerous microcystic spaces dissecting a fibrous stroma and lined by flattened to cuboidal cells with focal intraluminal papillary formation. This little-known diagnosis constitutes a diagnostic pitfall for dermatopathologists and dermatologists, and could be misdiagnosed as other benign or malignant entities. Through this case report, a practical approach and diagnostic keys have been devised to avoid misdiagnosis and overtreatment.

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“…Adenomatoid tumors are not associated with diabetes, but seven cases were found to be associated with hypertension. 9–14 Specific diseases are not found with adrenal adenomatoid tumors, but two cases with concomitant myelolipoma are reported in the literature 14 , one patient with human immunodeficiency virus 15 and onewith cocidiomycosis. Radiologically, adenomatoid tumors of the adrenal gland lack specific imaging features and are usually solid, but rarely may be extensively cystic.…”

Section: Discussionmentioning

confidence: 99%

“…Pathohistological and immunohistochemical examination are the only way to confirm the diagnosis for adenomatoid tumor. 2,4,8,15 …”

Section: Discussionmentioning

confidence: 99%

Adenomatoid Tumor of the Adrenal Gland in Young Woman: From Clinical and Radiological to Pathological Study

Krstevska¹,

Mishevska²,

Jovanović

2016

Rare Tumors

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Adenomatoid tumors are neoplasms of mesothelial origin, usually occurring in the male and female genital tracts. Extragenital localization sites such as adrenal glands are rare but have been reported. When found in the adrenals, they represent great clinical, radiological and pathological diagnostic challenge, with wide range of differential diagnoses to be considered. We present a case of a 30 years old female, with incidental ultrasound finding of unilateral tumor in the right adrenal gland. Multi slices CT scan was of value in localizing this tumor, but not in the precise diagnosis. The tumor ranged from 5.6 cm to 6.4 cm in greatest diameter. Clinical and hormonal examinations excluded Sy. Cushing, M. Conn and pheochromocytoma. The patient underwent laparoscopic right adrenalectomy. A large tumor (d: 8 × 7 × 3 cm) was removed showing no infiltration of the adrenal cortex or medulla, or extra-adrenal extension into the periadrenal adipose tissue. Histological examination showed numerous cystic spaces lined by flattened cubical epithelial cells. The small cystic spaces were separated by edematous fibrovascular stroma with rare epithelial cells with vacuolated cytoplasm. Immunohistochemical staining was positive with vimentin (+), S100 (+), MCA mesothelial Ag (+), CD 68 (+) and negative with acitin (-), CK7 (-), CD3 (-). Adenomatoid tumor is a rare benign neoplasm that should be added in the differential diagnosis of any adrenal tumor occurring in adrenal gland. The histological and immunohistochemical profiles of this adrenal adenomatoid tumor are very supportive in reaching the diagnosis of this benign tumor of a mesothelial cell origin, helping to avoid invasive treatment.

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Adenomatoid tumor of the right adrenal gland in a patient with AIDS

Cited by 22 publications

References 12 publications

Adenomatoid tumor of the adrenal gland: Case report with immunohistochemical study

Adenomatoid tumor of the adrenal gland: Case report with immunohistochemical study

Adenomatoid tumor of the skin: Differential diagnosis of an umbilical erythematous plaque

Adenomatoid Tumor of the Adrenal Gland in Young Woman: From Clinical and Radiological to Pathological Study

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