Adenomatoid odontogenic tumour: review of the literature and an analysis of 33 cases from South Africa

Mohamed, Ashraf; Singh, A.S.; Raubenheimer, Erich J.; Bouckaert, M.

doi:10.1016/j.ijom.2010.06.014

Cited by 51 publications

(56 citation statements)

References 15 publications

(39 reference statements)

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“…Clinically, AOTs are characterized by slow but progressive growth with few or no subjective symptoms [7,8]. The size of intraosseous lesions ranges from 1.0 to 3.0 cm c Rosette-like structures with eosinophilic amorphous material (''tumor droplets'') (arrow) (H&E 9400); d Duct-like spaces lined by a single row of columnar epithelial cells (arrow) (H&E 9200) [10].…”

Section: Discussionmentioning

confidence: 99%

“…The follicular type occurs intraosseously and presents as a well-defined, unilocular radiolucency associated with the crown and often part of the root of an unerupted tooth thus mimicking a dentigerous cyst [2]. The extrafollicular type also occurs within the bone but is not associated with an unerupted tooth [7]. This variant presents as a well-defined, unilocular radiolucency found between, above or superimposed upon the roots of erupted, permanent teeth.…”

Section: Introductionmentioning

confidence: 99%

“…This variant presents as a well-defined, unilocular radiolucency found between, above or superimposed upon the roots of erupted, permanent teeth. The peripheral type occurs extraosseously and often appears as a gingival fibroma or epulis attached to the labial gingival [2,7]. This variant may show erosion of the alveolar bone crest but rarely produces radiographically detectable changes [2].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the relatively large number of studies about demographic, clinical and radiologic features of AOT [4,7,9,11,12], information regarding the frequency of the many histopathologic aspects of this lesion is scarce [8,13,14]. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features, in order to provide useful additional data to the literature.…”

Section: Introductionmentioning

confidence: 99%

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Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Matos

Nonaka

Pinto

et al. 2012

Head and Neck Pathol

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Adenomatoid odontogenic tumor (AOT) is an uncommon benign epithelial lesion of odontogenic origin and, thus far, only few studies regarding the frequency of its many histopathologic features have been published in the literature. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features. Fifteen cases of AOT were studied considering their clinical, radiographic and histopathologic aspects. Twelve cases affected females and the mean age was 16.2 years. The anterior maxilla was the most common site (66.6 %) and radiographically most cases showed a unilocular radiolucency with well-defined borders (57.1 %). Histologically, most cases exhibited predominantly a solid growth pattern (46.7 %) or a similar proportion of solid and cribriform patterns (46.7 %). Eosinophilic amorphous material (''tumor droplets'') was found in all cases (100 %). Most tumors showed duct-like spaces (93.3 %) and convoluted structures (60.0 %) whereas a minor proportion of cases presented calcifying epithelial odontogenic tumor (CEOT)-like areas (26.7 %). Variable amounts of calcified material were found in most AOTs (80.0 %) whereas osteodentin and perivascular hyalinization were seen only rarely (6.7 % each one). Five (33.3 %) cases had areas mimicking a dentigerous cyst and most of these were diagnosed in females (80.0 %). Regarding the histopathologic features, our results suggest that AOTs usually show predominance of solid pattern or a similar proportion of solid and cribriform patterns while osteodentin and perivascular hyalinization are rarely seen in these tumors. In addition, areas mimicking a dentigerous cyst and CEOT-like areas are relatively infrequent findings in AOTs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Matos

Nonaka

Pinto

et al. 2012

Head and Neck Pathol

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“…When treatment consists of conservative enucleation and curettage, recurrences are rare. 4,5 We describe the occurrence and treatment of AOT in the anterior region of the maxilla associated with upper teeth impaction.…”

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confidence: 99%

Adenomatoid odontogenic tumor of the maxilla mimicking a dentigerous cyst

Pawlak¹,

Woźniak²,

Nelke³

2017

Dent. Med. Probl.

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Adenomatoid odontogenic tumor (AOT) is a rare benign tumor which originates in the odontogenic epithelium. Some theories indicate its glandular origin because of the incidence in the same embryological pouch. This form of odontogenic tumor rarely metastasizes and generally only requires regional excisional biopsy within healthy tissues. The tumor is commonly associated with an unerupted tooth, mimicking a dentigerous cyst. AOTs are usually located in the anterior portion of the maxilla and are seen more frequently in young female patients and occur in the second decade of life. These are mostly asymptomatic small lesions discovered incidentally on panoramic radiograph; however, when a bacterial co-infection is present, their diagnosis can be troublesome. Treatment is conservative enucleation and curettage. In most cases recurrences are rare. Due to the rare occurrence of this lesion and its clinical features, the authors described a case of AOT in a 15-year old female presenting as a cystic mass associated with unerupted maxillary anterior teeth.

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