Adenomas of the rete ovarii

Nogales, Francisco F.; Carvia, Rafael E.; Donné, C; Campello, Telma R.; Vidal, Marc; Martin, Alain

doi:10.1016/s0046-8177(97)90235-5

Cited by 35 publications

(30 citation statements)

References 9 publications

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“…These findings may help to explain the comparative rarity with which benign and malignant tumours arise in this structure compared with other sites in the female genital tract. [1][2][3] The lower levels of oestrogen receptor and progesterone receptor in the rete also suggest a lesser degree of responsiveness to hormone stimulation in this The Ki-67 protein growth fraction was expressed as the proportion of positive cells as a percentage of the total. Oestrogen receptor and progesterone receptor expression was quantified using the H score method.…”

Section: Discussionmentioning

confidence: 99%

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Ki-67, oestrogen receptor, and progesterone receptor proteins in the human rete ovarii and in endometriosis.

1999

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Aim-To examine proliferative activity using the Ki-67 protein, oestrogen receptor protein, and progesterone receptor protein expression in the rete ovarii, and to make comparisons with their expression in endometriosis. Methods-Immunohistochemistry was used to study the rete ovarii in 24 cases and endometriosis in seven cases, using antibodies to Ki-67 protein (growth fraction (GF) quantified using a point score method) and oestrogen receptor and progesterone receptor (quantified using the H score method). Results-There was no evidence of a significant diVerence in the Ki-67 protein, oestrogen receptor, and progesterone receptor in the rete ovarii in diVerent phases of the menstrual cycle (proliferative phase: GF = 1.052, oestrogen receptor H score = 13.4, progesterone receptor H score = 15.32; secretory phase: GF = 0.736, oestrogen receptor H score = 7.5, progesterone receptor H score = 1.84). The expression of all three proteins was greater in the foci of endometriosis (GF = 6.99, oestrogen receptor H score = 152.02, progesterone receptor H score = 127.36) than in the rete ovarii (p < 0.0005-0.0008, Mann-Whitney U test). Conclusions-There is a low rate of cellular proliferation in the rete ovarii and this structure shows less responsiveness to hormone stimulation than foci of endometriosis. These diVerences may provide a useful tool to distinguish the rete ovarii from endometriosis in cases of diagnostic diYculty. (J Clin Pathol 1999;52:517-520)

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Section: Discussionmentioning

confidence: 99%

“…Rarely it gives rise to cysts and to benign and malignant tumours. [1][2][3] Its major importance in human diagnostic practice is said to be in distinguishing it from endometriosis. 4 While there are histological criteria for distinguishing endometriosis from other conditions, the distinction may at times be diYcult.…”

mentioning

confidence: 99%

Ki-67, oestrogen receptor, and progesterone receptor proteins in the human rete ovarii and in endometriosis.

1999

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“…An example of the former is the identification of Leydig cells in rete cysts 22 and rete adenomas. 23 Both of these entities were documented to arise in the hilus of the ovary, and the associated Leydig cells are easily understood to derive from hilar cells. Carcinoid tumor is not usually associated with Leydig cells, but a stromal proliferation stimulating Leydig cells has been reported and illustrated in a strumal carcinoid.…”

Section: Discussionmentioning

confidence: 99%

Evidence that Leydig cells in Sertoli-Leydig cell tumors have a reactive rather than a neoplastic profile

Mooney

Man

Bratthauer

et al. 1999

Cancer

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“…The rete ovarii rarely gives rise to cysts and to benign and malignant tumors [3,4]. Clinically detectable ovarian cysts occurring in the rete ovarii have been reported in adult patients [3 -6].…”

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confidence: 99%