Adenomas of the breast.With case report of carcinomatous transformation in an adenoma

Hill, Robert P.; Miller, Frank Nelson

doi:10.1002/1097-0142(195403)7:2<318::aid-cncr2820070216>3.0.co;2-l

Cited by 32 publications

(11 citation statements)

References 2 publications

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“…15 Furthermore, there are cases of carcinoma arising within tubular adenomas in the literature. 16 17 We cannot rule out the possibility of an invasive carcinoma arising within a lactating adenoma in our case, perhaps brought about by the fluctuation of the hormonal milieu our patient experienced when she became pregnant while she was still nursing. In view of the fact that tubular adenomas and lactating adenomas are closely related, and may be variants of the same entity, our case and that reported by Hertel et al and Geschicker and Lewis may suggest that lactating adenomas too can be associated with an increased risk of cancer on certain occasions.…”

Section: Discussionmentioning

confidence: 79%

Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman

Saglam

Can²

2004

J Clin Pathol

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A 36 year old pregnant woman was admitted to hospital complaining of an enlarging mass in her left breast. Histopathological examination of the mastectomy specimen revealed a high grade infiltrating ductal adenocarcinoma intermixed with a lactating adenoma. Lactating adenomas are rare entities but are the most common masses that occur during pregnancy. Although they are not thought to carry an increased risk of cancer there are two other case reports in the literature of a lactating adenoma associated with an infiltrating carcinoma. In this case, areas where the lactating adenoma and the infiltrating carcinoma were intermixed could be identified. This case could simply be a collision tumour, although the possibility of an invasive carcinoma arising within a lactating adenoma cannot be ruled out. Because of the relative lack of experience with lactating adenomas, the question of an increased association with carcinoma development remains unclear.

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Section: Discussionmentioning

confidence: 79%

Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman

Saglam

Can²

2004

J Clin Pathol

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“…Approximately 50% of carcinomas occurring in fibroadenoma were lobular carcinoma in situ , and 35 and 15% of cases were invasive carcinoma and intraductal carcinoma, respectively 8 . To our knowledge, only two cases of carcinoma arising in tubular adenoma have been reported previously 7,8 . In 1954, Hill and Miller described the case of a 34‐year‐old woman with breast nodules showing multiple metastases 7 .…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] Due to the rare occurrence of tubular adenoma, the malignant transformation of tubular adenoma and concurrence of tubular adenoma and invasive ductal carcinoma have been reported only in two cases. 7,8 Here, we have described colocalization of a tubular adenoma and an invasive ductal carcinoma. The tumor might be the result of a collision between the two different tumors.…”

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confidence: 86%

Invasive ductal carcinoma associated with tubular adenoma of the breast

Domoto

Tsuda

Miyakawa

et al. 2002

Pathology International

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We report an extremely rare case of the colocalization of a tubular adenoma and an invasive ductal carcinoma occurring in a 55-year-old woman. Following radiographical evaluation, fine-needle aspiration cytology of the left breast tumor was undertaken. Because cytological examination revealed malignancy, a partial mastectomy was performed. Histologically, the tumor (measuring 1.7 x 1.3 cm) comprised two distinct parts: tubular adenoma and invasive ductal carcinoma. The invasive ductal carcinoma showed a solid pattern, high nuclear and structural atypia and frequent mitotic figures, while the tubular adenoma consisted of a proliferation of small ducts lined by single layers of epithelial and myoepithelial cells with bland nuclei and inconspicuous nucleoli. The histological boundary was clearly defined between the tubular adenoma and the invasive ductal carcinoma, and between the tubular adenoma and the surrounding breast tissue. The current case might be a collision between separate tubular adenoma and invasive ductal carcinoma, but the malignant transformation of a tubular adenoma cannot be ruled out. Both the long-term observation of this case and analysis of more cases may enable us to determine the histological characteristics and clinical significance of invasive ductal carcinoma associated with tubular adenoma.

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“…Rare cases have been described of in situ and/or invasive carcinoma involving adenomas. To the best of our knowledge, there were only four case report of carcinoma arising in TA of the breast (Hill et al, 1954;Fechner, 1987;Domoto et al, 2002;Saimura et al, 2012). In 1954, Hill and Miller described the first case of invasive carcinoma within the area of TA, and the liver metastasis of the breast carcinoma.…”

Section: 1269 Can Ultrasound Be Used To Differentiate Tubular Adenommentioning

confidence: 99%

Can Ultrasound be Used to Differentiate Tubular Adenomas of Breast from Fibroadenomas or Carcinoma?

Miao²,

Ge³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Breast tubular adenomas are rare benign breast tumors and detailed descriptions of their sonographic appearance are necessary for differential diagnosis from fibroadenomas or breast cancers. This study investigated twenty-one histology-proved tubular adenomas in 17 patients and also included 48 fibroadenomas in 35 patients as a control group. There was no significant difference between the two groups with clinical presentation, which was age, tumor location, tumor number (p>0.05). Statistic analysis showed three significant factors in the differential diagnosis of tubular adenomas and fibroadenomas, including macro-lobulation (p=0.01), "tiny branch like" patterns (p=0.001) and vascularity (p=0.02). Other ultrasonographic features such as echogenicity, border, uniformity of echotexture, posterior acoustic enhancement, lateral wall shadowing were of no clinical significance (p>0.05). Calcifications were seen in three tubular adenomas which were different from those of carcinomas. Although tubular adenomas have some typical characteristics on sonography, surgery and core needle biopsy are still needed for complex cases to exclude progress to malignancy.

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Adenomas of the breast.With case report of carcinomatous transformation in an adenoma

Cited by 32 publications

References 2 publications

Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman

Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman

Invasive ductal carcinoma associated with tubular adenoma of the breast

Can Ultrasound be Used to Differentiate Tubular Adenomas of Breast from Fibroadenomas or Carcinoma?

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