Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum

Kushima, Ryoji; Jonge, J. P. A. de; Borchard, F; Oellig, Frank; Stolte, Manfred

doi:10.1007/s00428-005-1242-2

Cited by 35 publications

(32 citation statements)

References 20 publications

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“…In 2003, we first reported systematic clinicopathological analyses of pyloric gland adenoma, in English language and Japanese journals [38,39]. Since then, there have been reported cases of pyloric gland adenoma arising in the proper esophagus [40], Barrett's esophagus [41], and in gastric heterotopia of rectum [42].…”

Section: Gastric-type Adenoma (Pyloric Gland Adenoma)mentioning

confidence: 99%

Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach

et al. 2006

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found that gastric carcinomas could be broadly divided into gland-forming adenocarcinomas and poorly differentiated carcinomas, which included signet-ring cell carcinomas. The former were found to retain intestinal features, and the latter tended to disclose a diffusely infiltrative growth pattern; Laurén referred to these as intestinal-type and diffuse-type, respectively, reporting that 53% of his samples were intestinal-type, 33% were diffuse-type, and the remaining 14% were unclassifiable [1].In the differentiated adenocarcinomas, intestinal metaplasia was often seen in the stomach, and intestinaltype cancers were thought to arise from the intestinal metaplasia. On the other hand, diffuse-type cancers did not retain intestinal characteristics, and they were considered to arise in the ordinary gastric mucosa, which was not involved in intestinal metaplasia [2,3]. In the middle of the 1980s, Helicobacter pylori was found to cause chronic active gastritis, and it was suggested that H. pylori played an important role in gastric carcinogenesis. In this respect, a hypothesis was that H. pylori caused chronic active gastritis with intestinal metaplasia, resulting in the development of intestinal-type adenocarcinomas [4,5].However, several studies appeared which described well-differentiated adenocarcinomas arising in nonintestinalized gastric mucosa, and there has been a question whether well-differentiated adenocarcinomas of the stomach were exclusively intestinal type. The recent discovery of MUC genes coding core proteins of mucin has identified the phenotypic expression of gastrointestinal neoplasms [6][7][8]. The disease entity of "gastric-type well-differentiated adenocarcinoma" has recently been accepted, especially in Japan and Europe. This entity has often been a clinicopathological subject of discussion, especially in Japanese journals, because its biological behavior is possibly highly malignant, in spite of the difficulty of making endoscopic and histopathological diagnoses [9,10]. AbstractSince 1985, when gastric-type well-differentiated adenocarcinomas were demonstrated in hyperplastic polyps of the stomach, we have studied phenotypic expression in gastrointestinal epithelial lesions. The recent discovery of MUC genes coding core proteins of mucin has improved research on the phenotypic expression of gastrointestinal neoplasms. The disease entity of gastric-type well-differentiated adenocarcinoma has recently been accepted, especially in Japan and Europe. This entity has often become a clinicopathological subject of discussion, because its biological behavior is possibly highly malignant, in spite of the difficulty in making endoscopic and histopathological diagnoses. Even under these circumstances, the term "gastric adenoma" usually means flat adenoma of the intestinal type. Gastric-type adenomas have been regarded as exceptional until recently. Although gastric-type adenomas could theoretically be classified into foveolar type and pyloric-gland type, foveolar-type adenoma is, in practice, difficult t...

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Section: Gastric-type Adenoma (Pyloric Gland Adenoma)mentioning

confidence: 99%

Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach

et al. 2006

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“…1 d), leading to a final diagnosis of high-grade pyloric gland adenoma originating from heterotopic gastric mucosa within the duodenal bulb. The present case illustrates an extragastric pyloric gland adenoma originating from heterotopic gastric mucosa, as has so far been documented in only two other duodenal lesions [1,3] and one rectal lesion [5]. Gastric heterotopia, however, appears to be the prerequisite for tumor histogenesis.…”

mentioning

confidence: 77%

Hemobilia as a rare complication after endoscopic ultrasound-guided fine-needle aspiration for hilar cholangiocarcinoma

Kawakubo

Isayama²,

Takahara³

et al. 2011

Endoscopy

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“…The exact mechanism for the development of heterotopic gastric mucosa in the rectum remains to be seen. Several theories including developmental errors or prior inflammatory reactions have been postulated [3,5] . The majority of the reported patients were symptomatic, and complete relief could be obtained following treatment including surgical resection, endoscopic polypectomy or ablation [6] .…”

Section: Discussionmentioning

confidence: 99%

“…In our case the biopsy from the rectal polyp exhibited foveolar hyperplasia, and the biopsy from the whitish discolored area demonstrated heterotopic fundic and pyloric-type gastric mucosa, showing clear correlation between endoscopic features and histopathologic findings. There have been previous reports of Helicobacter pylori infection and the development of adenoma in heterotopic gastric mucosa of the rectum [5,7] .…”

Section: Discussionmentioning

confidence: 99%

Heterotopic fundic and pyloric-type gastric mucosa in the rectum presented as a foveolar hyperplastic polyp

Nakanishi¹,

Merenda

2014

CRCP

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Heterotopic gastric mucosa has been identified in all levels of the gastrointestinal (GI) tract. However, the finding of heterotopic gastric mucosa in the rectum is rare. We report a rare case of a 48-year old male with heterotopic fundic and pyloric-type gastric mucosa in the rectum incidentally found by sigmoidoscopy. A sessile polyp measuring 1.3 cm in diameter is surrounded by whitish discolored area measuring 3.0 cm in diameter. Histologic examination of the biopsy from the whitish discolored area demonstrated fragments of rectal mucosa with heterotopic fundic and pyloric-type gastric mucosa, whereas histologic examination of the biopsy from the rectal polyp showed fragments of heterotopic pyloric-type gastric mucosa with foveolar hyperplasia, which can explain the polypoid appearance. No intestinal metaplasia or Helicobacter pylori are identified. Our case is unique in that the lesion appeared as a polyp due to the foveolar hyperplasia.

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Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum

Cited by 35 publications

References 20 publications

Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach

Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach

Hemobilia as a rare complication after endoscopic ultrasound-guided fine-needle aspiration for hilar cholangiocarcinoma

Heterotopic fundic and pyloric-type gastric mucosa in the rectum presented as a foveolar hyperplastic polyp

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