Adenoma Prevalence in Blacks and Whites Having Equal Adherence To Screening Colonoscopy: The National Colonoscopy Study

Prevalence of Advanced, Precancerous Colorectal Neoplasms in Black and White Populations: A Systematic Review and Meta-analysis

“…The I 2 values indicate moderate heterogeneity among studies. These findings remained unchanged with the largest study 19 excluded and in the subgroup of 5 studies 17,18,20,21,23 ("best subset") in which the results in each individual study were adjusted for age and sex ( Table 3). I 2 values for these two subgroups reflect low-to-moderate study heterogeneity.…”

“…Of the 162 articles, 153 were excluded (Figure 1), leaving 9 studies that met all inclusion criteria and no exclusion criteria. [16][17][18][19][20][21][22][23][24] Descriptive characteristics of the 9 studies are shown in Table 2. The 9 articles included 302,128 participants and were published between 2010 and 2017.…”

“…All studies were cross-sectional, 5 of which collected data prospectively. 16,19,[21][22][23] Six studies involved single sites, [16][17][18][20][21][22] while the remaining three 19, 23,24 were multisite studies, one of which 19 included 84 practices throughout the U.S. All study populations were average-risk. The criteria for advanced adenoma were comparable across studies except for the largest study, which used "polyp > 9 mm" without including polyp histology.…”

“…Large serrated polyps were included in the definition of advanced adenoma in two studies. 20,23 All studies defined "proximal" as the splenic flexure and colon segments proximal to it. Six studies reported no differences in AA prevalence between Blacks and Whites, 1 study reported a higher AA prevalence in Whites, 1 study reported higher prevalence in Blacks, and 1 reported a higher prevalence of large polyps in Blacks.…”

“…bias. [17][18][19][20][21]23 The three studies with high-risk for bias 16,22,24 did not adjust prevalence for age and sex, a critical feature for a valid comparative analysis.…”