Adenoma of the nipple: a mimic of breast malignancy

Quintana-Codina, Monica; Pérez-Muñoz, Noelia; Fernández‐Figueras, María Teresa; Altemir, Arcadi; Salleras, M.

doi:10.5070/d327553621

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…We see no reason why NAs would be more likely to transform into carcinoma or confer increased risk for the same, other than the mere fact of there being more epithelial tissue for it to arise within. Most authors agree that the incidence of carcinoma in NA is similar to the general population 23 …”

Section: Discussionmentioning

confidence: 79%

Nipple Adenoma

Weigelt

Sciallis

McIntire

et al. 2023

American Journal of Surgical Pathology

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Nipple adenoma (NA) is a rare, benign proliferation of the nipple ducts. It may be clinically mistaken for Paget disease or squamous cell carcinoma; thus, microscopic evaluation is paramount. A large case series of NA has not been undertaken since the 1980s. Therefore, we undertook this study to evaluate the clinicopathologic characteristics of NA, emphasizing differential diagnoses and follow-up data. We retrieved 50 cases from our in-house archives or consultation files between 2003 and 2022. Available slides were reviewed, and clinical data and follow-up information were obtained. Cases must have exhibited a dense ductal proliferation in the breast tissue with proximity to the nipple epidermis. All patients were women; median age was 56 years. In all, 68% of patients were symptomatic; 53% demonstrated a skin growth. Overall, 67% were excised completely, either primarily (33%) or via re-excision after biopsy (33%). Four histologic patterns were noted: adenosis (dense proliferation of small-to-medium ducts); large duct (medium-to-large caliber ducts); papillary-like (frond-like architecture with branching, slit-like lumens); and pseudoinfiltrative (ducts squished and distorted by dense stromal fibrosis). Follow-up in 44 patients (88%) with a median time of 66 months showed no evidence of recurrence. NA demonstrates a wide spectrum of histopathologic variation. Subtyping of this entity is unlikely to be clinically relevant. Differentiation from invasive carcinoma or other histologic mimics (syringocystadenoma papilliferum, syringomatous adenoma) may be difficult. Simple excision is curative, and recurrence is rare. A definitive link to invasive carcinoma has not been established.

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Section: Discussionmentioning

confidence: 79%

Nipple Adenoma

Weigelt

Sciallis

McIntire

et al. 2023

American Journal of Surgical Pathology

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“…Erosive Adenomatosis of the Nipple (EAN), also known as nipple adenoma, papillary adenoma of the nipple, or florid papillomatosis, is an uncommon benign epithelial tumor that originates from the lactotrophic ducts of the nipple-areola complex. It was first reported as a benign intraductal papilloma in 1951 by Haagensen et al 1 , 2 …”

Section: Discussionmentioning

confidence: 99%

“…Histopathology reveals a glandular, well-circumscribed, non-encapsulated proliferation coated by a characteristic double layer of cells composed of an external layer of cubic or flattened myoepithelial cells and an internal layer of cuboidal or cylindrical epithelial cells, which can present apocrine secretory projections on its luminal border. 1 The absence of cytologic atypia is an important feature.…”

Section: Discussionmentioning

confidence: 99%