Adenoma Malignum Op the Cervix

McKelvey, J.L.; Goodlin, R. R.

doi:10.1097/00006254-196310000-00045

Cited by 2 publications

(4 citation statements)

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“…Silverberg and Hurt questioned this prognosis because four of five patients in their series were disease-free for at least 3 years [5]. More recently, findings by Gilks et al [6] for the largest case study were in agreement with those of McKelvey and Goodlin [4] and Kaku and Enjoji [13]. However, Hirai et al reported that most neoplasms in these unfavorable reports were discovered at an advanced stage [7].…”

Section: Discussionmentioning

confidence: 83%

“…An early report suggested an unfavorable prognosis in patients with AM [4]. Silverberg and Hurt questioned this prognosis because four of five patients in their series were disease-free for at least 3 years [5].…”

Section: Discussionmentioning

confidence: 99%

“…In 1963, McKelvey and Goodlin reported five AM cases [4]. In 1975, the term minimal deviation adenocarcinoma was proposed by Silverberg and Hurt [5] for tumors with good differentiation and a good prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases

Lim

Lee

Kim

et al. 2012

The Kaohsiung J of Med Scie

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The aim of this study was to evaluate the clinical and pathologic features of a rare tumor (adenoma malignum, AM). We retrospectively analyzed the medical records of 18 patients diagnosed with AM at a single institute between March 1992 and November 2009. The median age of the patients was 45.8 years (range 29-76 years) and the mean follow-up period was 49.2 months (range 4-168 months). A preoperative cytologic diagnosis (Papanicolaou smear) of AM was made in 22.2% (4/18) of the cases. Ten (55.6%) of the 18 patients were misdiagnosed with other benign diseases and underwent hysterectomies, which confirmed AM. Sixteen patients with AM were in the early stage (IB1, 11/18; IB2, 5/18) and the other two patients were in the advanced stage. Fourteen of 18 patients (77.8%) had pure AM alone. Adjuvant therapy was administered to eight of the patients (44.4%) with AM. The recurrence rate was zero, but the disease progressed in two of the patients (11.1%), who died of the disease. The 5-year survival rate was 88.8%. A cytological diagnosis of AM based on a Papanicolaou smear is rarely made; a deep biopsy (cone biopsy or endocervical curettage) is necessary to diagnose this rare tumor preoperatively when there is any clinical suspicion of AM.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases

Lim

Lee

Kim

et al. 2012

The Kaohsiung J of Med Scie

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“…The most common initial symptom is watery vaginal discharge. Several studies have reported a poor prognosis7–9, whereas some found a relatively favorable prognosis similar to that of other well‐differentiated cervical adenocarcinomas5, 10.…”

Section: Introductionmentioning

confidence: 97%