Adenoma–carcinoma sequence in intrahepatic cholangiocarcinoma

Pinho, André Costa; Melo, Renato Bessa; Oliveira, Armando M.; Almeida, Marinho; Lopes, Joanne; Graça, Luís; Costa-Maia, José

doi:10.1016/j.ijscr.2012.01.002

Cited by 24 publications

(17 citation statements)

References 9 publications

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“…Identification of oncogenic mutations in BDA supports a benign neoplasm rather than reactive process and suggests that BDA may be an early lesion in the pathogenesis of ICC, which has been shown to harbor BRAF V600E mutations [54,55] . Furthermore, the finding of coexistence of benign lesions, dysplastic lesions and carcinoma (authors' unpublished data) and progression of BDA to ICC [9] strongly suggests an adenoma-dysplasia-carcinoma pathway, as seen in colorectal carcinogenesis. BRAF V600E mutation was not identified in von Meyenberg complexes, supporting distinct etiologies with different molecular and biological processes [46] .…”

Section: Hamartomamentioning

confidence: 91%

“…ICC in a background of BDA mixed with minor component of BDH is reported in the literature [51] (also present in authors' unpublished case report). There has also been a report of progression of BDA to ICC [9] . BDA is a rare lesion and has been found in 0.0008%-0.006% of patients in two large autopsy series [52,53] .…”

Section: Hamartomamentioning

confidence: 99%

“…Von Meyenburg complex (VMC) is suggested to be a possible premalignant lesion of ICCs due to the occasional association of VMC with ICCs and reports of VMC-like cystic ICCs [6][7][8] . Progression of bile duct adenoma (BDA) to ICC has also been reported [9] . The major clinical and histological characteristic features of above lesions are summarized in Figure 1 and Table 1.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Ettel¹

2015

WJH

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Cholangiocarcinoma (CC) is primarily a malignant tumor of older adults most prevalent in Southeast Asia, where liver fluke infestation is high. However the etiology in western countries is unknown. Although the incidence of extrahepatic cholangiocarcinoma has remained constant, incidence of intrahepatic CC (ICC) which differs in morphology, pathogenesis, risk factors, treatment and prognosis is increasing. While this increase is associated with hepatitis C virus infection, chronic nonalcoholic liver disease, obesity, and smoking, the pathogenesis of ICC and molecular alterations underlying the carcinogenesis are not completely elucidated. Benign biliary lesions such as biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, von Meyenburg complex or bile duct hamartoma, and bile duct adenoma have been associated with ICC. For each of these entities, evidence suggests or supports a role as premalignant lesions. This article summarized the important biological significance of the precursor lesions of ICC and the molecular mechanisms that may be involved in intrahepatic cholangiocarcinogenesis.

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Section: Hamartomamentioning

confidence: 91%

Section: Hamartomamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Ettel¹

2015

WJH

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“…Mazzaferro et al 2 have nicely shown that time to transplantation (TTT) was strongly associated with a dramatic increase in the probability to find viable tumor in the ablation zone (30%/3 months of waiting time). The TTT was shorter in the Vouche et al study (6. 4 In addition, as Vouche et al did not report histologic data concerning the nontumorous liver, the comparison of the method to segmentectomy appears to be somewhat overstated.…”

Section: To the Editormentioning

confidence: 99%

Quick diagnosis of hepatic encephalopathy: Fact or fiction?

2014

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“…However, interestingly, some BDAs are known to exhibit neoplastic potential followed by classical peripheral ICC [18, 22]. It seems therefore plausible that BDAs may be a heterogeneous group or have a broad morphological spectrum.…”

Section: Precursor and Premalignant Lesions Of Peripheral Iccmentioning

confidence: 99%

What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?

Nakanuma

Tsutsui

Ren

et al. 2014

International Journal of Hepatology

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Cholangiocarcinoma (CC) is divided into distal, perihilar, and intrahepatic CCs (ICCS), and are further subdivided into large bile duct ICC and peripheral ICC. In distal and perihilar CC and large duct ICC, biliary intraepithelial neoplasm (BilIN) and intraductal papillary neoplasm (IPN) have been proposed as precursor lesions. Peripheral ICC, bile duct adenoma (BDA), biliary adenofibroma (BAF), and von Meyenburg complexes (VMCs) are reportedly followed by development of ICCs. Herein, we surveyed these candidate precursor lesions in the background liver of 37 cases of peripheral ICC and controls (perihilar CC, 34 cases; hepatocellular carcinoma, 34 cases and combined hepatocellular cholangiocarcinoma, 25 cases). In the background liver of peripheral ICC, BDA and BAF were not found, but there were not infrequently foci of BDA-like lesions and atypical bile duct lesions involving small bile ducts (32.4% and 10.8%, resp.). VMCs were equally found in peripheral CCs and also control CCs. In conclusion, BDA, BAF, and VMCs are a possible precursor lesion of a minority of peripheral CCs, and BDA-like lesions and atypical bile duct lesions involving small bile ducts may also be related to the development of peripheral ICC. Further pathologic studies on these lesions are warranted for analysis of development of peripheral ICCs.

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Adenoma–carcinoma sequence in intrahepatic cholangiocarcinoma

Abstract: Cholangiocarcinogenesis is a complex multi-step mechanism and further investigations are needed to fully understand this process.

Cited by 24 publications

References 9 publications

Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Quick diagnosis of hepatic encephalopathy: Fact or fiction?

What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?

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