Adenoma bronquioloalveolar asociado a bronquiolitis obliterante y leishmaniasis pulmonar en el sida

Herrejón, Alberto; Cervera, Angela; Maciá, M.; Ferrer, Roser; Blanquer, Rafael

doi:10.1157/13073174

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…As seen in the present study, pulmonary involvement in VL has a bronchoalveolar pattern (9), which is similar to bacterial pneumonia. In addition, the distributed nodular pattern was reported in only a person with VL and HIV/AIDS (6). Conversely, our patient did not have immunodeficiency.…”

Section: Discussioncontrasting

confidence: 50%

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Visceral Leishmaniasis with Massive Pulmonary Involvement: A Case Report

et al. 2019

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Visceral leishmaniasis (VL) is an endemic disease in East and South Africa and the Mediterranean area. Fever, splenomegaly, and weakness are the most common symptoms of VL, but pulmonary involvement is very rare. The present study reports a patient with VL and pulmonary complication. An 18-year-old immunocompetent patient was referred to a local hospital with submandibular lymphadenopathy, nonproductive cough, and occasional fever. In spiral chest CT scan, bilateral massive bronchopulmonary consolidation with a diffused nodular pattern was seen. After a few days, because of absent response to antibiotic therapy and prednisolone, fine needle aspiration from pulmonary nodules was done that showed multiplex Leishman bodies. The patient showed a good response to amphotericin B and glucantime.

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Section: Discussioncontrasting

confidence: 50%

“…The patient in the present study was examined for HIV and tuberculosis since Leishmania is common in these cases (5)(6)(7)14). Moreover, VL or its treatment may cause the incidence of pulmonary tuberculosis, which requires special treatment of the patient (12,14).…”

Section: Discussionmentioning

confidence: 99%

Visceral Leishmaniasis with Massive Pulmonary Involvement: A Case Report

et al. 2019

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“…Por meio da análise dos dados obtidos a partir do formulário foi constatado o surgimento de sinais clínicos respiratórios durante a contaminação pelo parasita em 44,4% dos pacientes (n = 4), dentre eles a tosse e a dispneia, evidenciando a presença do envolvimento respiratório na LV. Reforçando os nossos resultados, Marshall et al (24) descrevem a tosse e a dispneia em seu estudo de caso, enquanto que Herrejon et al (23) relatam episódios de tosse como sintoma comumente encontrado na LV. Durante a infestação pela LV, a reprodução do parasita acarreta aumento dos órgãos toracoabdominais afetados, provocando uma distensão abdominal considerável (35).…”

Section: Discussionunclassified

Adaptações crônicas sobre a função pulmonar em indivíduos infectados pela leishmaniose visceral

Silva¹,

Silva²,

Pires³

et al. 2013

Fisioter. mov.

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ResumoIntrodução: Apesar de escassas, as principais alterações cardiopulmonares verificadas durante a infecção com Leishmaniose Visceral (LV) se referem a alterações histológicas e imunológicas e poucos relatos de repercussões funcionais. Objetivo: Verificar e analisar a existência de adaptações crônicas na função pulmonar de indivíduos assintomáticos previamente infectados pela LV. Materiais e métodos: Trata-se de um estudo do tipo transversal descritivo, para o qual foram selecionados todos os indivíduos que contraíram LV em Parnaíba (Piauí, Brasil) entre 2007 e 2010 de acordo com informações do Setor de Epidemiologia do município. De um total de 20 indivíduos com confirmação parasitológica de LV, foram avaliados nove com idades entre 18 e 62 anos entre setembro e outubro de 2011. Excluíram-se indivíduos que não apresentaram diagnóstico parasitológico de LV, doenças ou sintomas cardiorrespiratórios recentes, usuários crônicos de drogas ilícitas e gestantes. Foram realizadas medidas antropométricas e testes de espirometria e de manovacuometria conforme Fisioter Mov. 2013 abr/jun;26(2):403-11 da Silva AO, Silva SB, Pires CBR, Gonçalves LSL, Coertjens PC, Coertjens M. 404 especificações da American Thoracic Society / European Respiratory Society (ATS/ERS). Para comparação das médias dos valores medidos e preditos foi realizado Teste t Student para dados dependentes. O nível de significância adotado foi p < 0,05. Resultados: A Capacidade Vital Forçada (CVF) (3,8 ± 0,9 vs. 4,2 ± 0,8 L) e o Volume Expiratório Forçado no primeiro segundo (VEF 1 ) (3,3 ± 0,7 vs. 3,5 ± 0,7 L) foram estatisticamente menores do que os valores medidos (p < 0,01). A relação VEF 1 /CVF (87,6 vs. 84,4%) foi maior nos valores medidos (p = 0,08). Conclusão: Apesar de o número de indivíduos avaliados ser pequeno, os dados indicam que a infecção por LV parece desenvolver adaptações crônicas sobre o sistema respiratório, resultando em volumes pulmonares significativamente diminuídos e uma tendência a padrões respiratórios restritivos. [P] Palavras-chave: Leishmaniose Visceral. Sistema respiratório. Testes de função pulmonar. [B] Abstract Introduction: Although scarce, the main changes observed during cardiopulmonary infection with Visceral Leishmaniasis (VL) refer to histological and immunological and few reports of functional repercussions. Objective: To verify and analyze the existence of chronic adaptations in pulmonary function in individuals who have been infected by VL. Materials and methods: It is a descriptive cross-sectional study, which evaluated nine people aged between 18 and 62 years. Anthropometric measurements and spirometry and manometer tests were performed according to the specifications of the American Thoracic Society / European Respiratory Society (ATS/ERS). For comparison of the measured and predicted values was performed Student t test for dependent data. The level of significance was p < 0.05. Results: The Forced Vital Capacity (FVC) (3,8 ± 0,9 ± 0,8 vs. 4,2 l) and Forced expiratory volume in first second (FEV 1 ) (3...

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“…Nevertheless, dry cough was noted in 16% and 25.9% of the cases in two retrospective studies [ 24 , 25 ], and in separate case reports [ 26 , 27 , 28 , 29 ]. Bronchial mucosa involvement has been described in immunocompetent [ 26 , 30 ], immunocompromised [ 28 , 29 , 31 ], and bronchial asthma patients [ 32 ]. In all cases, bronchoalveolar lavage fluid (BALF) and bronchial mucosal biopsies were obtained via bronchoscopy and led to the diagnosis of VL.…”

Section: Introductionmentioning

confidence: 99%

Bronchoscopy and Lung Fine-Needle Aspiration for Antemortem Evaluation of Pulmonary Involvement in Dogs with Naturally Occurring Canine Leishmaniosis

et al. 2022

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Clinical manifestations from the lower respiratory tract are rare in canine leishmaniosis (CanL), making bronchoscopy and lung fine-needle aspiration (FNA) seldomly justified. The aim of this prospective study was to investigate the involvement of Leishmania infantum in the lungs of dogs with naturally occurring CanL by bronchoscopy and examination of bronchoalveolar lavage fluid (BALF), bronchial mucosa biopsies, and FNA, using immunodiagnostics. Dogs with relevant concurrent diseases and azotemia were excluded. Cough was detected in 5/31 (16.1%) dogs. Lesions (hyperemia, edema, mucosal granularity, secretions) were identified upon bronchoscopy in 19/31 (61.3%) dogs. The cytology of BALF revealed histiocytic inflammation in 14/31 (45.2%) dogs; the parasite was identified in one dog (3.2%). The immunofluorescence antibody test in BALF was positive in 15/31 (48.4%) dogs. Histopathology of bronchial mucosa and/or adjacent alveoli revealed lesions (mononuclear cell infiltration, fibrosis, edema, thickening of the inter-alveolar septa) in 24/31 (77.4%) dogs, with no Leishmania amastigotes. Positive antigen staining was observed within the cytoplasm of mononuclear cells in immunocytochemistry and immunohistochemistry. Μononuclear cells showed antigenic positivity in bronchial mucosa (27/31; 87.1%), BALF (30/31; 96.8%), and lung FNA (27/31; 87.1%). In conclusion, lungs seem to be affected from CanL more commonly than previously believed, and bronchoscopy allows obtaining valuable samples for antemortem diagnosis.

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Adenoma bronquioloalveolar asociado a bronquiolitis obliterante y leishmaniasis pulmonar en el sida

Cited by 9 publications

References 7 publications

Visceral Leishmaniasis with Massive Pulmonary Involvement: A Case Report

Visceral Leishmaniasis with Massive Pulmonary Involvement: A Case Report

Adaptações crônicas sobre a função pulmonar em indivíduos infectados pela leishmaniose visceral

Bronchoscopy and Lung Fine-Needle Aspiration for Antemortem Evaluation of Pulmonary Involvement in Dogs with Naturally Occurring Canine Leishmaniosis

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