Adenoid hypertrophy and chronic rhinosinusitis: Helicobacter pylori on antral lavages, adenoid tissue and salival inmunoglobuline A on paediatric patients

Cedeño, Eleazar E. Graterón; Ortiz-Princz, Diana; Figueredo, Sinay A. Ceballos; Porro, María Eugenia Cavazza

doi:10.1016/j.ijporl.2015.11.019

Cited by 6 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanisms of SIgA action mainly involve inhibition of microbial adhesion to the mucosal surface, neutralization of toxins and sterilization, as well as anti-inflammatory regulation and conditioning. Previous studies have shown that SIgA is closely correlated with occurrence and development of many diseases, such as chronic sinusitis ( 26 ), repeated respiratory tract infection ( 27 ), and oral cancer ( 28 ), among others. Regulating sIgA levels is beneficial in improving mucosal immunity of clinical diseases.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis

Wang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

ObjectiveThis study sought to explore the role of metabolic disturbance in immunoregulation of gingivitis targeting T helper 17 cells (Th17)/regulatory T cell (Treg).Materials and MethodsA total of 20 gingivitis patients and 19 healthy volunteers were recruited. Quantitative real time polymerase chain reaction (qRT-PCR) was used to evaluate expression patterns of Forkhead box protein P3 (Foxp3), transforming growth factor-β (TGF-β), retinoid-related orphan receptor-gammat (RORγt) and interleukin 17A (IL-17A) in the peripheral blood lymphocytes of subjects across the two groups. Moreover, the enzyme-linked immunosorbent assay (ELISA) technique was used to detect levels of TGF-β, IL-4, IL-6,TL-10 and L-17A secreted in the plasma as well as the SIgA secreted in saliva. Flow cytometry was used to detect the percentage of CD4+CD25+ Foxp3+Treg cells and the percentage of CD4+IL-17A+ Th17 cells in whole blood of subjects in both groups. Gas chromatography-mass spectrometry (GC-MS) was employed to analyze the plasma metabolites in the gingivitis patient group. Statistical analysis was applied to determine whether the plasma metabolites and related metabolic pathways significantly differed between gingivitis patients and healthy controls. Ingenuity pathway analysis (IPA) was employed to identify the potential relation between the metabolites and the Th17 and Treg related pathway.ResultsThe percentages of CD4+IL17A+Th17 cells and IL-17 significantly increased in the peripheral blood in the gingivitis group. Moreover, the upregulation of IL-17A mRNA and RORγt mRNA were also found in the gingivitis group. However, the percentage of CD4+CD25+ Foxp3+Treg cells and Foxp3 mRNA in the whole blood did not significantly change. However, TGF-β mRNA as well as TGF-β, IL-4, IL-6, IL-10 in the periperial blood and SIgA in the saliva were higher in the gingivitis group. Notably, that the ratio of Th17/Treg cells was significantly increased during peripheral circulation. Furthermore, we identified 18 different metabolites which were differentially expressed in plasma between the gingivitis and healthy control groups. Notably, the levels of cholesterol, glycerol 1-octadecanoate, d-glucose, uric acid, cyclohexaneacetic acid, 3-pyridine, tryptophan, and undecane 2,4-dimethyl were significantly up-regulated. whereas the levels of lactic acid, glycine, linoleic acid, monopalmitic acid, glycerol, palmitic acid, pyruvate, 1-(3-methylbutyl)-2,3,4,6-tetramethylbenzene, 1 5-anhydro d-altrol, and boric acid were down-regulated in the gingivitis group, relative to healthy controls. IPA showed that these metabolites are connected to IL17 signaling, TGF-B signaling, and IL10 signaling, which are related closely to Th17 and Treg pathway.ConclusionOverall, these results showed that disturbance to glycolysis as well as amino and fatty acid metabolism are associated with Th17/Treg balance in gingivitis. Impaired immunometabolism may influence some periodontally involved systemic diseases, hence it is a promising strategy in targeted development of treatment therapies.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis

Wang

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The majority of studies evaluating this relationship have been performed in the adult population; however, there are an increasing number of studies being performed in the pediatric population as more non-invasive techniques for detecting H. pylori have been developed. In the pediatric studies, regardless of technique, no studies have consistently been able to identify H. pylori or structures compatible with the microorganism with most studies finding no evidence of bacteria in their samples [22]. Recently, Grateron Cedeno et al failed to detect the presence of H. pylori in adenoid tissue or maxillary sinus in PCRS patients despite using high-sensitivity and -specificity diagnostic techniques.…”

Section: Pathophysiology Of Adenoid Contribution To Pediatric Chromentioning

confidence: 99%

“…Recently, Grateron Cedeno et al failed to detect the presence of H. pylori in adenoid tissue or maxillary sinus in PCRS patients despite using high-sensitivity and -specificity diagnostic techniques. In their conclusion they emphasize an unlikely role of the microorganism in PCRS without nasal polyps and adenoidal hypertrophy and/or chronic adenoiditis etiology [22].…”

Section: Pathophysiology Of Adenoid Contribution To Pediatric Chromentioning

confidence: 99%

The Role of the Adenoids in Pediatric Chronic Rhinosinusitis

Belcher

Virgin

2019

Medical Sciences

View full text Add to dashboard Cite

There are several mechanisms by which the adenoids contribute to pediatric chronic rhinosinusitis (PCRS), particularly with children aged 12 years and younger. Understanding the role that the adenoids play in PCRS is crucial when attempting to treat these patients. A literature review was performed to address this problem and provide information surrounding this topic. This review will provide a better understanding of how adenoids contribute to PCRS, and also of the medical and surgical treatment options.

show abstract

“…The indication to perform at first a simple adenoidectomy (tonsillectomy is not indicated) is due to the strong relationship that exists between AH and CRS. Some authors prefer to speak of relationship between CRS and adenoiditis [18,19,20] rather than between AH and CRS, but most prefer the latter, in consideration of the etiology of AH as a likely consequence of chronic adenoiditis [17,21,22,23]. Over the past few years, several authors demonstrated the correlation between AH and CRS through different types of studies, based on the endoscopic study of the adenoid volume [24] on the same bacterial strains both on the adenoidal tissue and in the nasal sinuses [20,22,23,25,26,27,28] on the positive effects on CRS by adenoidectomy [21,29,30,31] on specific immunologic modifications [32,33,34] and on radiological findings [35].…”

Section: Discussionmentioning

confidence: 99%

“…The authors underlined that this type of infection is rare in other parts of the world, but the data is still of great interest considering modern world complex migration. A further study carried out by the Cedeño group [23] focused instead on the search for Helicobacter pylori at the nasal, sinus, and adenoid level, driven by the assumption that gastroesophageal reflux is a risk factor for AH and CRS, even if there is no consensus in literature regarding this relationship [6]. Unfortunately, the authors were never able to identify the organism.…”

Section: Discussionmentioning

confidence: 99%

Adenoidal Disease and Chronic Rhinosinusitis in Children—Is there a Link?

Bulfamante

Saibene

Felisati

et al. 2019

JCM

View full text Add to dashboard Cite

Adenoid hypertrophy (AH) is an extremely common condition in the pediatric and adolescent populations that can lead to various medical conditions, including acute rhinosusitis, with a percentage of these progressing to chronic rhinosinusitis (CRS). The relationship between AH and pediatric CRS has been extensively studied over the past few years and clinical consensus on the treatment has now been reached, allowing this treatment to become the preferred clinical practice. The purpose of this study is to review existing literature and data on the relationship between AH and CRS and the options for treatment. A systematic literature review was performed using a search line for “(Adenoiditis or Adenoid Hypertrophy) and Sinusitis and (Pediatric or Children)”. At the end of the evaluation, 36 complete texts were analyzed, 17 of which were considered eligible for the final study, dating from 1997 to 2018. The total population of children assessed in the various studies was of 2371. The studies were categorized as surgical-observational, microbiological, genetic-immunological, and radiological. The analysis of the studies confirms the relationship between AH and CRS and supports the existing consensus on medical and surgical therapy. Furthermore, these studies underline the necessity to adapt medical and surgical treatment considering age, comorbidities including asthma and, if present, the Computed Tomography (CT) score.

show abstract

Adenoid hypertrophy and chronic rhinosinusitis: Helicobacter pylori on antral lavages, adenoid tissue and salival inmunoglobuline A on paediatric patients

Cited by 6 publications

References 27 publications

Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis

Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis

The Role of the Adenoids in Pediatric Chronic Rhinosinusitis

Adenoidal Disease and Chronic Rhinosinusitis in Children—Is there a Link?

Contact Info

Product

Resources

About