Adenoid Cystic Carcinoma of the Breast: A Case Series of Six Patients and Literature Review

Lee, Dae-Won; Im, Jin Hee; Suh, Koung Jin; Keam, Bhumsuk; Moon, Hyeong‐Gon; Im, Seock‐Ah; Han, Wonshik; Park, In Ae; Noh, Dong‐Young

doi:10.4143/crt.2014.46.1.93

Cited by 36 publications

(28 citation statements)

References 14 publications

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“…The c-KIT, EGFR expression, and Ki-67 activity is typically low in these cases. 48 Clearly, a large proportion of patients harbor indolent tumors and may survive 5 to 10 years even with little or no therapy, yet others have tumors that grow more rapidly and some have tumors that grow rapidly only after a period of relative stability. A recent analysis of more than 2600 European patients with metastatic ACC confirmed that degree of variability in the clinical course, but overall observed that nearly two thirds of the patients had died after 5 years.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…It is also important to note that although ACC in the breast can seem initially like invasive ductal carcinoma and is typically triple negative (estrogen receptor, progesterone receptor, and HER‐2) it has a generally more favorable prognosis than conventional triple negative breast carcinomas and ACCs arising at other sites. The c‐KIT, EGFR expression, and Ki‐67 activity is typically low in these cases 48. Clearly, a large proportion of patients harbor indolent tumors and may survive 5 to 10 years even with little or no therapy, yet others have tumors that grow more rapidly and some have tumors that grow rapidly only after a period of relative stability.…”

Section: Introductionmentioning

confidence: 99%

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Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Chakraborty²,

et al. 2015

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BackgroundAdenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this study, recent advances in molecular characterization and in therapeutics are reviewed.MethodsA search of articles in PubMed and of abstracts from national meetings was performed regarding ACC.ResultsRecent genetic analyses found that recurrent chromosome 6:9 translocations in ACC generate an MYB:NFIB gene fusion resulting in overexpression of the MYB oncoprotein. Several other frequent mutations are recently published that may be relevant for drug development. Several trials of targeted drugs are reviewed. Some agents delay tumor progression, but tumor responses remain rare.ConclusionACCs have a characteristic chromosomal translocation, but also frequently pick up additional mutations. Clinical research is limited by the rarity and slow growth of ACC. Several ongoing trials are testing agents that inhibit fibroblast growth factor receptor signaling or other signaling pathways. Novel treatments based on the recently sequenced tumor genome are under development. © 2015 The Authors Head & Neck Published by Wiley Periodicals, Inc. 38: 620–627, 2016

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Chakraborty²,

et al. 2015

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“…For example, ACC of the breast and skin are believed to be less aggressive than similar tumours of the major salivary gland, lung and bronchus [20,21]. …”

Section: Discussionmentioning

confidence: 99%

Breast Neoplasms with Dermal Analogue Differentiation (Mammary Cylindroma): Report of 3 Cases and a Proposal for a New Terminology

et al. 2015

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Salivary gland-like and dermal analogue tumours of the breast are rare lesions that can be diagnostically challenging for pathologists. Data on the clinical behaviour and molecular characterisation of these mammary tumours are limited and their designation is mainly based on similar salivary gland or skin lesions. In this study, we present three cylindromatous breast tumours. These lesions were located within the breast, had ill-defined margins and were composed of nests containing a dual population of cytologically bland cells, surrounded at least partially by basement membrane-like material. The lack of cytological atypia and absence of mitoses led to the diagnosis of benign mammary cylindroma in 1 case. The expression of oestrogen receptor, focal absence of basement membrane material and the focal infiltrative nature together with patchy absence of peripheral basement membrane supported the diagnosis of malignancy in the other 2 cases. We discuss the morphological criteria, immunohistochemical profile and diagnostic pitfalls of these tumours. We also review the literature including previously reported cases of mammary cylindroma and differential diagnoses to be considered before making a diagnosis. We propose the term ‘mammary tumours with cylindromatous differentiation', implying their uncertain malignant nature, and propose management strategies.

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“…When ACC patients have local recurrence or distant metastasis, they still show a sustained and slow progression. Because a longer course of disease increases the risk of recurrence and distant metastasis, the long term follow-up is required (Kim et al, 2014). …”

Section: Prognosismentioning

confidence: 99%

Current Status and Progress of Breast Adenoid Cystic Carcinoma

Zhai¹,

You²,

Zhang³

et al. 2017

cge

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Adenoid cystic carcinoma (ACC) of the breast is a rare subtype of breast cancer. Despite its triple-negative status, this tumor has a very good prognosis. Breast-conserving treatment including postoperative radiotherapy seems to be equivalent to mastectomy alone with respect to survival. Routine axillary lymph node staging is not recommended since lymph node metastases are extremely rare. The value of adjuvant systemic therapies is not established. Late relapses can occur, so long-term follow-up is mandatory for these patients.

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Adenoid Cystic Carcinoma of the Breast: A Case Series of Six Patients and Literature Review

Cited by 36 publications

References 14 publications

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Breast Neoplasms with Dermal Analogue Differentiation (Mammary Cylindroma): Report of 3 Cases and a Proposal for a New Terminology

Current Status and Progress of Breast Adenoid Cystic Carcinoma

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