Adenoid cystic carcinoma of the breast

Schulenburg, C.A.R.; Pepler, W. J.

doi:10.1002/bjs.1800560520

Cited by 4 publications

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References 4 publications

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“…We were able to identify 182 cases of ACC of the breast in the world's published literature dating back to 1945 2, 10–52. The incidence of ACC observed in our own study, 0.05%, is almost identical to the 0.10% incidence in the literature 11, 29, 34, 45.…”

Section: Discussionsupporting

confidence: 61%

Adenoid cystic carcinoma of the breast

Arpino

Clark

Mohsin

et al. 2002

Cancer

178

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BACKGROUND The objective of this study was to comprehensively characterize the clinical and biologic features of adenoid cystic carcinoma (ACC) and to assess the implications for management in a large cohort of patients. METHODS From a database of 50,000 patients, 28 were identified with ACC for which clinical follow‐up and biologic information was available. The biologic features examined included estrogen receptor and progesterone receptor status, DNA ploidy, and S‐phase fraction. Median follow‐up was 83 months with a range of 29 to 144 months. Overall survival and disease free survival curves were drawn using Kaplan and Meier estimates and were compared by the log‐rank test. RESULTS All but one patient were postmenopausal with a median age at diagnosis of 66 years (range, 40–96 years). One patient had macroscopic metastatic disease at diagnosis. Median tumor size was 1.9 cm (range, 0.5–7.0 cm). Axillary lymph node dissection was performed in 23 patients. Only 1 patient (4%) had histologic positive lymph nodes (2 of 10), and no recurrence was detected for this patient. Forty‐six percent were ER positive (median, 16 fmol/mg protein; range, 5–1017 fmol/mg), and 35% were PgR positive (median, 61 fmol/mg protein; range, 6–854 fmol/mg). S‐phase fraction and DNA ploidy were assessable in 24 cases. Ninety percent of tumors had low S‐phase (median, 3.3%; range, 0.1–34.2%), and 92% were diploid. Simple or modified radical mastectomy was performed in 22 patients, and 6 patients were treated by lumpectomy. Five of these six patients also received radiation therapy after lumpectomy. Despite the different surgical approaches, there were no local recurrences. The 5‐year disease free survival rate was 100%, and the 5‐year overall survival rate was 85% (95% confidence interval, 71.7–98.6%). CONCLUSIONS Adenoid cystic carcinomas of the breast have very favorable biologic characteristics and, consistent with this, an excellent prognosis. Good local control can be achieved by lumpectomy with radiation or by simple mastectomy. Axillary lymph node dissection is not helpful in clinical management. Cancer 2002;94:2119–27. © 2002 American Cancer Society. DOI 10.1002/cncr.10455

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Section: Discussionsupporting

confidence: 61%

Adenoid cystic carcinoma of the breast

Arpino

Clark

Mohsin

et al. 2002

Cancer

178

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The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

Fisher

Gregorio²,

Fisher³

et al. 1975

Cancer

716

140

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The inter-relationships of 32 pathologic and 7 clinical parameters encountered in the study of 1000 examples of invasive breast carcinoma have been presented. In some instances the biological significance of these associations is at present unclear. In others it is to be noted that there is no information provided as to the rank of their significance. Nevertheless, the associations that were encountered not only help further characterize the various forms of breast cancer but also provide information regarding the possible biological significance of some of their features. Although it is not our intention to minimize the possible significance of the inter-relationships of pathologic parameters, most emphasis in the summarizing statements which follow has been placed upon those correlations which may relate to prognosis. In this regard reference has been made to short-term treatment failure, vis a vis local recurrence and/or metastases, which may not necessarily accurately reflect patient survival, although generally such a relationship exists. Information in this regard as well as to the rank of the significance of these pathologic features shall be forthcoming when sufficient time has elapsed since the inception of this study to allow for such conclusions, i.e. survival or long-term treatment failure rates. Lastly, it becomes evident that the guidelines followed in the examination of these specimens appear to represent at least the minimum requirements necessary for a meaningful pathologic evaluation of breast carcinoma.

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Pathology of Breast Cancer

Fisher

1977

Current Approaches to Therapy

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Adenoid cystic carcinoma of the breast

Cited by 4 publications

References 4 publications

Adenoid cystic carcinoma of the breast

Adenoid cystic carcinoma of the breast

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

Pathology of Breast Cancer

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