Adenoid cystic carcinoma of the sinonasal tract: outcome of endonasal endoscopic surgery at five-year follow up

Gendeh, Balwant Singh; Zahedi, Farah Dayana; Ahmad, Helal Said; Kew, Thean Yean

doi:10.1017/s0022215113000480

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…It represents 3 to 5% of all head and neck cancers [9] and about 6 to 10% of malignant tumors of the salivary glands [9]. With a low incidence of lymph node and distant metastases, between 3 and 5.5% [7]. Sayan M et al, Estimate that the annual global incidence rate is 0.4 to 13.5 cases per 100,000 habitants [8].…”

Section: Discussionmentioning

confidence: 99%

“…Resulting in a low morbidity radiation technique with low risk for associated complications. Follow-up MRI and periodic endoscopic evaluations were performed for 2.5 years after definitive treatment, since it is the best modality to identify recurrent lesions, evaluate the skull base, perineural spread and intracranial extension [7]. During the follow-up period, no recurrent lesions were found.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors are usually diagnosed in a locally advanced stage, as the symptoms can be mistaken as chronic rhinosinusitis or inflammatory changes on CT scan images [7].…”

Section: Introductionmentioning

confidence: 99%

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Expanded Endoscopic Endonasal Approach and Adjuvant Radiotherapy for the Treatment of Locally Advanced Sinonasal and Skull Base Adenoid Cystic Carcinoma: Case Report and Literature Review

Escobar

2021

GJO

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Introduction: Adenoid Cystic Carcinoma of the sinonasal and skull base region is a challenging tumor to treat due to its late onset of presentation and frequent compromise of vital neurovascular structures. Surgical treatment followed by conventional irradiation are the optimal treatment options, often requiring extensive open approaches and mutilating interventions due to its localization. Endoscopic endonasal approaches are relatively new procedures that combined with new adjuvant radiation techniques could achieve similar oncological outcomes with significant less morbidity.Methods: We present the case of a patient with non-metastatic Adenoid Cystic Carcinoma (ACC) locally advanced of the sinonasal and skull base region diagnosed and treated at the Instituto Nacional de Cancerología of Bogotá D.C, Colombia between the years 2017 and 2020 who underwent endoscopic endonasal tumor resection and subsequent adjuvant management with Intensity modulated radiotherapy (IMRT).Results: Endoscopic and imaging control was performed according to the protocol of the surgical group with nasal endoscopies every 3-4 months during the first 2 years and serial images every 6 months. Follow up for 35 months with adequate local control and minimal aesthetic or functional sequelae.Conclusion: Multidisciplinary management with endoscopic endonasal resection and adjuvant radiotherapy appears to be an effective oncological alternative to open surgical procedures, with less morbid and minor functional sequelae, for patients with locally advanced ACC tumors of the sinonasal region.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Expanded Endoscopic Endonasal Approach and Adjuvant Radiotherapy for the Treatment of Locally Advanced Sinonasal and Skull Base Adenoid Cystic Carcinoma: Case Report and Literature Review

Escobar

2021

GJO

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“…The literature to date is limited to small case series of SNACC, offering little data to guide treatment . Previous groups have attempted to identify factors influencing overall survival (OS), disease‐free survival (DFS), and local recurrence (LR) with conflicting results.…”

Section: Introductionmentioning

confidence: 99%

The endoscopic endonasal approach for sinonasal and nasopharyngeal adenoid cystic carcinoma

et al. 2019

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Objective: To determine factors affecting outcomes for patients with sinonasal and nasopharyngeal adenoid cystic carcinoma (SNACC) treated using the endoscopic endonasal approach (EEA) with preservation of key structures followed by adjuvant radiotherapy (RT).Method: Retrospective case series of 30 patients treated at the University of Pittsburgh between 2000 and 2014. Hospital records were reviewed for clinical and pathologic data. Outcome measures included overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) rates.Results: The majority of patients had T4a and T4b disease (23.3%, and 63.3%). Microscopically positive margins were present in 21 patients (63.6%). Positive margins were present in nine patients (30.0%). The mean and median follow-up were 3.97 and 3.29 years. Five-year OS, DFS, LRFS, and DMFS were 62.66%, 58.45%, 87.54%, and 65.26%. High-/intermediate-grade tumors had worse DFS (P = .023), and LRFS (P = .026) (HR = 4.837, 95% CI, 1. 181-19.812). No factors were associated with significantly worse DMFS. No patient suffered CSF leak, optic nerve, or internal carotid injury. The mean and median length of hospital stay was 4.1 days and 2.0 days (range: 0-32 days).Conclusion: Organ-preserving EEA with adjuvant RT for low-grade SNACC offers 5-year survival similar to that reported by other studies, which include radical, open skull base surgery. Patients with high-grade disease do poorly and may benefit from novel treatment strategies. For low-grade disease, organ-preserving EEA with RT may be the best option, offering a balance of survival, quality of life, and decreased morbidity for patients with this difficult-to-cure disease.

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“…It is the third most common malignancy of paranasal sinuses with most common site being maxillary sinus followed by nasal cavity, nasopharynx and ethmoid sinus. 4 It is most commonly seen in 4 t h and 5 t h decade with female predominance. 5 ACC arising from nasal septum is very rare with only 10 cases published in literature.…”

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confidence: 99%

Adenoid cystic carcinoma of nasal septum: A review of literature

Singh

Poonia

Kumari³

et al. 2021

IJOAS

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Adenoid cystic carcinoma(ACC) is a common salivary gland tumour which constitutes about 10% of all salivary gland malignancies and 1% of all head & neck malignancies. It is a slow growing tumour with propensity for perineural invasion., It occurs most commonly in minor salivary glands, most commonly in oral cavity. It is the third most common malignancy of paranasal sinuses with most common site being maxillary sinus followed by nasal cavity, nasopharynx and ethmoid sinus. It is most commonly seen in 4 and 5 decade with female predominance. ACC arising from nasal septum is very rare with only 10 cases published in literature. In this paper we present a case of nasal septal adenoid cystic carcinoma with review of the literature.

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Adenoid cystic carcinoma of the sinonasal tract: outcome of endonasal endoscopic surgery at five-year follow up

Abstract: Adenoid cystic carcinoma is difficult to treat. Sinonasal tract tumours can be resected via endoscopic endonasal resection or endoscopic assisted craniofacial resection, but prolonged follow up is advisable. Radiotherapy is an important adjuvant treatment.

Cited by 11 publications

References 19 publications

Expanded Endoscopic Endonasal Approach and Adjuvant Radiotherapy for the Treatment of Locally Advanced Sinonasal and Skull Base Adenoid Cystic Carcinoma: Case Report and Literature Review

Expanded Endoscopic Endonasal Approach and Adjuvant Radiotherapy for the Treatment of Locally Advanced Sinonasal and Skull Base Adenoid Cystic Carcinoma: Case Report and Literature Review

The endoscopic endonasal approach for sinonasal and nasopharyngeal adenoid cystic carcinoma

Adenoid cystic carcinoma of nasal septum: A review of literature

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