Adenoid cystic carcinoma of the salivary glands: an immunohistochemical study

Abstract

Twenty‐four cases of adenoid cystic carcinoma from the Salivary Gland Registry of the University of Hamburg were analysed with respect to their differentiation and subclassification. With immunohistochemical methods, several groups of marker substances were analysed in these tumors: marker for a glandular function; immunoglobulins; metalloproteins; tumor markers; substances associated with the basal membrane and carbohydrate chains. The following patterns of histological differentiation were found: cribriform pattern with typical pseudocysts; tubular pattern with ductal elements; trabecular pattern with predominance of hyalininzed stromal elements; basaloid pattern with low differentiated cells. For every pattern, a special immunohistochemical profile could be established. The morphological and immunohistochemical analysis revealed the following relation between the different patterns: Origin of the malignant proliferation is presumably the terminal ductal system of the salivary glands (indifferent cell of the reserve cell type). This cell can differentiate in 2 directions: a myoepithelial and a ductal cell type. Immunohistochemically, the presence of basement membrane‐associated substances is accompanied by the appearance of myoepithelial‐like cells. The presence of secretory products is a feature of ductal cells.

Iron-binding proteins in adenoid cystic carcinoma of salivary glands: an immunohistochemical study.

“…Our results showed transferrin was present in small angular cells. However, this finding conflicts with prior observation that transferrin was negative in myoepithelial cells of tubular, trabecular and cribriform patterns (Caselitz et al 1986b). The biological significance of the presence of transferrin in ACC remains unexplained.…”

“…Tohoku J. Exp. Med., 1991, 163 (1), [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] An immunoperoxidase staining technique was used for detecting three major iron-binding proteins (transferrin, ferritin and lactoferrin) in 54 adenoid cystic carcinomas (ACCs) of major and minor salivary glands. Twenty-three normal salivary glands were investigated for comparison.…”

“…Furthermore, transferrin and ferritin have been reported in benign salivary gland tumors (Sehested et al 1985;Takahashi et al 1988). More recently Caselitz et al (1986b) have documented the presence of many markers including iron-binding proteins in ACC. However, detailed studies of their presence in ACC of salivary gland have not been undertaken.…”

“…Most pseudocysts are larger than true lumina, but lumina may occasionally dilate to the size of small pseudocysts (Dardick 1985). Caselitz et al (1986b) reported that anti-lactoferrin antiserum was not identified in the pseudocysts. Our study showed that the material in pseudocyst-like spaces stained with anti-lactoferrin antiserum.…”

Nano-hydroxyapatite and its contemporary applications

“…Conflicting data on role of certain markers including S100, vimentin, cytokeratins, c-kit and glial fibrillary acidic protein have been published. [15][16][17] However, proliferative markers can be used supportively to establish a diagnosis. Usually, the proliferative index in PLGA is <5%, whereas in AdCC it is usually >20%.…”