Adenoid cystic carcinoma of the maxillary sinus: a clinical–pathological report of 10 years of experience from a single institution

Andrade, Marília Ferreira; Faria, Paulo Rogério de; Cardoso, Sérgio Vitorino; Santos, Marcello Roter M; Dias, Fernando Luiz; Eisenberg, A.; Santos, Izabella Costa; Loyola, A.M.

doi:10.1016/j.ijom.2014.06.016

Cited by 19 publications

(24 citation statements)

References 23 publications

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“…However, although major and minor salivary glands are affected by this tumor, 50%–70% of cases are presented in minor salivary glands [1, 2]. ACC affects both males and females, without any gender predilection, especially in their fifth to seventh decades of life [3]. Although a study by Gill and Frattali, 2015, reported slight female predominance, Gondivkar et al, 2011, mentioned that there was no gender predominance [5, 6].…”

Section: Discussionmentioning

confidence: 99%

“…ACC grows slowly over time and most patients presented advanced stages [8]. The carcinoma cells originating from duct-type epithelial and myoepithelial cells of salivary glands have a dark blue nucleus, arranged in solid nests, tubular, cribriform patterns with pseudo-cystic spaces [3, 4]. The tumor is graded by the pattern of neoplastic cells arrangement [5, 6].…”

Section: Discussionmentioning

confidence: 99%

“…The tumor is graded by the pattern of neoplastic cells arrangement [5, 6]. Solid type of ACC is composed of dark neoplastic cells arranged in a solid nests pattern in more than 30% of the entire tumor and has an aggressive behavior with high recurrence rate and lymph nodes metastasis, and most patients present at an advanced stage [3, 4]. In the differential diagnosis of ACC, polymorphous low-grade adenocarcinoma, basaloid squamous cell carcinoma, small cell neuroendocrine carcinoma, and adenosquamous cell carcinoma can be considered.…”

Section: Discussionmentioning

confidence: 99%

“…It mostly affects the minor salivary glands and is histologically composed of small basaloid cells arranged in solid, cribriform, and trabecular pattern [1, 2]. Regardless of the benign histopathological appearance of ACC, it potentially has local invasion with late recurrence rate and distant metastasis [3]. The most prognostic predictive factors are tumor size, grade, stage, lymph node involvement, neural invasion, and margin status.…”

Section: Introductionmentioning

confidence: 99%

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Aggressive Adenoid Cystic Carcinoma of Maxillary Sinus in a 43-Year-Old Male: Rare Case Report and Review of Literature

Rahmani

Zahir

Yazdi

et al. 2017

Case Reports in Medicine

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Adenoid cystic carcinoma (ACC) is a rare malignant tumor, mostly involving the minor salivary glands. Herein, we present a case of ACC in a 43-year-old man with symptoms of dental abscess as the initial presentation of the tumor. In spiral computed tomography (CT) scan, soft tissue mass with the erosion of maxillary sinus wall on the right side of the alveolar ridge was evident. Histopathological examination of the excised tumor with immunohistochemical studies (C-kit, Vimentin, pan-cytokeratin, p53, p63, and ki67 positive reaction) confirmed grade 2 ACC in the maxillary sinus. The patient underwent hemimaxillectomy and right-neck dissection. Due to the extension of tumor cells excessively into the surrounding tissues and involvement of orbital bone, complete and total resection of the tumor with safe margins could not be done. After surgery, adjuvant radiotherapy was considered for the patient. At the end of treatment, the patient lost his eye vision. Seventeen months from initial diagnosis, he was still alive without lung or distant metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aggressive Adenoid Cystic Carcinoma of Maxillary Sinus in a 43-Year-Old Male: Rare Case Report and Review of Literature

Rahmani

Zahir

Yazdi

et al. 2017

Case Reports in Medicine

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“…They exhibit slow but not indolent behavior, and are associated with early perineural invasion, frequent local recurrence, delayed distant metastasis, and eventual death [2,3].…”

Section: Introductionmentioning

confidence: 99%

The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck

Homma¹,

Sakashita²,

Hatakeyama³

et al. 2015

Acta Oto-Laryngologica

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CONCLUSIONS: Superselective intra-arterial cisplatin infusion with concomitant radiotherapy (RADPLAT) is considered to be one of the treatments of choice for patients with adenoid cystic carcinoma (ACC) who prefer not to undergo radical surgery. OBJECTIVE:To evaluate the efficacy of RADPLAT for patients with ACC of the head and neck. PATIENTS AND METHODS:Between 2001 and 2010, 9 patients with untreated ACC were given superselective intra-arterial infusion of cisplatin (100-120 mg/m 2 /week) with simultaneous intravenous infusion of thiosulfate to neutralize cisplatin toxicity and radiotherapy (65-70Gy). RESULTS:Five patients had tumors arising in the base of tongue, 2 in the maxillary sinus, and the remaining 2 in the nasopharynx. The median follow-up period was 9y7m (range 4y6m -12y5m), and the 5-year local control (LC), overall survival (OS), and disease-free survival rates were 88.9 %, 88.9%, and 55.6%, respectively. The 10-year OS rate was 57.1%, but all patients who remained alive for over 10 years are still alive with disease. Primary tumor recurrence was observed in 5 of the 9 patients, with the median time to recurrence being 6y (range 4-9 years). Five of the 9 patients had distant metastasis, and all of these 3 patients also had primary recurrence.

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Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review

et al. 2022

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Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their

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Adenoid cystic carcinoma of the maxillary sinus: a clinical–pathological report of 10 years of experience from a single institution

Cited by 19 publications

References 23 publications

Aggressive Adenoid Cystic Carcinoma of Maxillary Sinus in a 43-Year-Old Male: Rare Case Report and Review of Literature

Aggressive Adenoid Cystic Carcinoma of Maxillary Sinus in a 43-Year-Old Male: Rare Case Report and Review of Literature

The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck

Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review

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