Adenoid Cystic Carcinoma of the Scalp with Pulmonary Metastasis

Sanderson, K.V.; Batten, John

doi:10.1177/003591577506801021

Cited by 20 publications

(23 citation statements)

References 4 publications

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“…The PubMed‐based search revealed a total of 114 PCACC published cases the majority of which were part of case reports, with only a couple of small series and four relatively large series first authored by Seab & Graham, Urso et al, Ramakrishnan et al and North et al, which included 10, 5, 27 and 19 PCACC cases, respectively. After including our three cases, complete clinical information was found in 116 cases with 1 case that was reported as part of an immunohistochemical study did not include any clinical data .…”

Section: Resultsmentioning

confidence: 99%

Primary cutaneous adenoid cystic carcinoma with MYB aberrations: report of three cases and comprehensive review of the literature

et al. 2016

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Adenoid cystic carcinoma (ACC) is a relatively rare slow growing and often-aggressive epithelial-myoepithelial neoplasm that arises in multiple organs including the skin. The t(6;9) (q22–23;p23–24) translocation, resulting in a MYB-NFIB gene fusion has been found in ACCs from the salivary glands and other organs. Recently, MYB aberrations occurring in a subset (40%) of primary cutaneous ACC (PCACC) examples was described. Herein, we report 3 additional cases of PCACC harboring MYB aberrations. The tumors presented in 3 males aged 43, 81 and 55 years old and affected the extremities in the first 2 patients and the scalp in the third one. None of the patients had history of prior or concurrent ACC elsewhere. Lesions exhibited the classic ACC morphology of nests of basaloid cells arranged in cribriform and adenoid patterns. Sentinel lymph node biopsy was performed in two cases with one case showing lymph node positivity. Fluorescence in situ hybridization with break-apart probes for MYB and NFIB loci revealed that 2 cases showed MYB rearrangements while one case showed loss of one MYB signal. None of the cases showed NFIB rearrangements. We contribute with 3 additional cases of PCACC exhibiting MYB aberrations, the apparent driving genetic abnormality in these tumors.

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Section: Resultsmentioning

confidence: 99%

Primary cutaneous adenoid cystic carcinoma with MYB aberrations: report of three cases and comprehensive review of the literature

et al. 2016

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“…Primary cutaneous adenoid cystic carcinoma (ACC) is a rare, aggressive subtype of the sweat gland carcinomas, and approximately 40 cases have been reported 1–9 . This tumour generally affects middle‐aged and older individuals.…”

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confidence: 99%

“…Distant metastases of ACC of cutaneous origin are extremely rare 4 . Only five cases with visceral metastasis have been reported in the world literature and all of these were pulmonary and the primary sites of the tumours were the scalp 2,3,5,6,8 . Nodal metastasis from cutaneous ACC is also rare 3 …”

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confidence: 99%

Primary cutaneous adenoid cystic carcinoma with lung and lymph node metastases

Doğanay¹,

Bilgi²,

Aygıt

et al. 2004

Acad Dermatol Venereol

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“…The duration of the illness (from first appearance of the rodent ulcer to the development of pulmonary metastases) was occasionally short, but there were five cases where the interval was more than 20 years (and these included two cases of more than 30 years). With the exception of the patient described by Sanderson and Batten (1975), all cases were invariably fatal.…”

Section: Discussionmentioning

confidence: 89%

Pulmonary metastases from basal-cell carcinoma of skin.

Sakula¹

1977

Thorax

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Sakula, A. (1977). Thorax, 32,[637][638][639][640][641][642] Pulmonary metastases from basal-cell carcinoma of skin. Although rodent ulcers are a relatively common malignant condition of the skin, pulmonary metastases arising from them are extremely rare. There have so far been only 29 authenticated reports of this condition.A further case is described of a man who, at the age of 35, developed a rodent ulcer (typical basal-cell carcinoma) on the forehead. Despite local excisions, skin grafting, and radiotherapy, the ulcer continued to recur, although there was no spread to regional lymph nodes. When he was aged 52, he developed widespread bilateral pulmonary lesions and a right pleural effusion. Thoracotomy provided a lung biopsy which showed the typical histological appearance of basal-cell carcinoma. He died aged 54, 19 years after the onset of the rodent ulcer, and necropsy confirmed that the pulmonary lesions were bloodborne metastases of basal-cell carcinoma.Rodent ulcers are the commonest form of malignant disease of the skin. Whereas squamous-cell carcinoma of the skin characteristically spreads to regional lymph nodes, rodent ulcers of the skin (basal-cell carcinoma) were, until recent times, considered to be an entirely localised form of skin malignancy showing no tendency to distant metastasis (MacLeod

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Adenoid Cystic Carcinoma of the Scalp with Pulmonary Metastasis

Cited by 20 publications

References 4 publications

Primary cutaneous adenoid cystic carcinoma with MYB aberrations: report of three cases and comprehensive review of the literature

Primary cutaneous adenoid cystic carcinoma with MYB aberrations: report of three cases and comprehensive review of the literature

Primary cutaneous adenoid cystic carcinoma with lung and lymph node metastases

Pulmonary metastases from basal-cell carcinoma of skin.

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