Adenoid cystic carcinoma of the larynx presenting with unusual subglottic mass: Case report

Kashiwagi, Takashi; Kanaya, Hiroaki; Konno, Wataru; Goto, Kazutaka; Hirabayashi, Hideki; Haruna, Shinichi

doi:10.1016/j.anl.2015.12.011

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…Including our case, this report reviews a total of ten cases of primary ACC with thyroid invasion ( Table 1 ). 5 , 6 , 19 – 24 These ten cases included four male (40%) and six female patients (60%). Their ages ranged from 17 to 68 years, with the average age being 49.8 years.…”

Section: Discussionmentioning

confidence: 99%

“…Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumor that usually originates in the salivary glands, 1 , 2 submandibular glands, and minor salivary glands, but it can also occasionally occur in the mammary glands, cervix, Bartholin glands, sinuses, skin, 3 , 4 and even the larynx and trachea. 5 , 6 Tracheal adenoid cystic carcinoma (TACC) is a rare, low-grade, malignant tumor that originates in the glands of the tracheal and bronchial walls. The histological structure and biological behavior of TACC are similar to those of tumors found in the salivary glands, and TACC most commonly occurs in the upper trachea, being found in the joint cartilage in the posterior aspect of the trachea.…”

Section: Introductionmentioning

confidence: 99%

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Primary adenoid cystic carcinoma of the trachea with thyroid invasion: a case report and literature review

Qi¹,

Liang²,

Li³

et al. 2016

OTT

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Primary adenoid cystic carcinoma (ACC) of the trachea with thyroid invasion is very rare. In this report, we present a 46-year-old man with primary ACC of the trachea with thyroid invasion. ACC invasion of the thyroid is very rare and is easily misdiagnosed. The patient sought consultation due to a 6-month history of dysphagia and associated dyspnea. A contrast-enhanced computed tomography scan obtained at the time of admission revealed bilateral thyroid masses and tracheal wall thickening. The thyroid masses were fused to the trachea and the esophagus without discernible borders, intraoperatively. Frozen pathology suggested poorly differentiated cancer, and a bilateral partial thyroidectomy was performed. Postoperative pathology revealed primary tracheal ACC with thyroid invasion. The patient died 1 month after surgery. We have also summarized the literature on the clinical presentation, diagnosis, and treatment of thyroid-invasive ACC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary adenoid cystic carcinoma of the trachea with thyroid invasion: a case report and literature review

Qi¹,

Liang²,

Li³

et al. 2016

OTT

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“…Since ACC usually occurs as a large asymptomatic and non-ulcerated submucosal mass, the diagnosis is often delayed. Indeed, early ACC could be clinical misdiagnosed as asthma and other chronic tracheobronchial diseases or laryngeal amyloidosis [9]. When our patient was referred to our ENT Department the disease was already at an advanced stage, despite dyspnea and dysphagia appeared a few months before.…”

Section: Discussionmentioning

confidence: 88%

Laryngeal Adenoid Cystic Carcinoma: A rare neoplasm with still undefined treatment aspects. Case report and literature review

Grilli¹,

Giancaspro²,

Fiore³

et al. 2020

Arch Otolaryngol Rhinol

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Adenoid Cystic Carcinoma (ACC) is a rare malignant tumor, accounting for about 1% of head and neck malignancies and 10% of salivary gland cancers. The laryngeal localization of ACC is particularly rare because of the paucity of accessory salivary glands in this anatomical district. Prevalence is highest in the fi fth and sixth decade of life with a slight female predilection and aetiology is unknown. Since laryngeal ACC characteristically grows slowly and occurs in the subglottis, the diagnosis, which is based on the combination of physical examination with fi beroscopy and neck-chest Computerized Tomography (CT), is often delayed. Nowadays the debate is still open about which is the best comprehensive therapy of this tumor. We present the case of a laryngeal ACC in a 68 year-old-woman, treated with total laryngectomy together with bilateral neck dissection and a literature review made with the purpose to point out the most recent advancements towards the defi nition of a gold-standard therapy. Laryngectomy results as the fi rst choice treatment, while chemotherapy has minimal effects on this neoplasm and radiotherapy alone does not show the capacity to lead to complete resolution, but there is still the need of further studies to clarify the usefulness and the role played by neck dissection and postoperative radiotherapy.

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“…To date, 9 cases of laryngeal ACC with thyroid invasion have been reported ( Table 1 ) [4,5,[8][9][10][11][12] . Thyroid nodules are common findings, and about 97% of them are primary (benign or malignant).…”

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review

Shirian

Maghbool²,

Aledavood³

et al. 2017

Acta Cytologica

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Background: Adenoid cystic carcinoma (ACC) of the larynx and trachea is very rare. Case: A 45-year-old man with ACC of the larynx presenting as a thyroid mass is reported in this study. Physical examination revealed a large solid thyroid nodule in the left lobe without any lymphadenopathy. A technetium thyroid scan showed multinodular goiter with cold nodules in the left lobe, isthmus, and functioning nodules in the right lobe. A large thyroid mass originating from the left side of the larynx, mostly the left vocal cord and the infraglottic part, was seen using enhanced magnetic resonance imaging after rupture of the thyroid cartilage on the left side. Ultrasound-guided fine needle aspiration smears and cell blocks of the thyroid nodule showed highly cellular smears composed of large tissue fragments, three-dimensional clusters, and sheets of neoplastic cells with slightly enlarged round and hyperchromatic nuclei. Immunohistochemical study showed that the cell block expressed C-kit and CK 7 on the cribriform growth pattern of the tumoral cells. However, protein expression of thyroglobulin and thyroid transcription factor-1 was not detectable. Conclusion: To approach a thyroid nodule, direct invasion or metastatic tumors of other organs must be borne in mind.

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Adenoid cystic carcinoma of the larynx presenting with unusual subglottic mass: Case report

Cited by 11 publications

References 12 publications

Primary adenoid cystic carcinoma of the trachea with thyroid invasion: a case report and literature review

Primary adenoid cystic carcinoma of the trachea with thyroid invasion: a case report and literature review

Laryngeal Adenoid Cystic Carcinoma: A rare neoplasm with still undefined treatment aspects. Case report and literature review

Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review

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