Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management

Herzberg, Arlene J.; Bossen, Edward H.; Walther, Philip

doi:10.1002/1097-0142(19910901)68:5<1015::aid-cncr2820680518>3.0.co;2-z

Cited by 46 publications

(29 citation statements)

References 16 publications

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“…[1][2][3][4][5][6][7] Most adenoid cystic carcinomas follow a favorable clinical course with a low prevalence of axillary lymph node metastases (approximately 10%). Tumors showing a predominant solid pattern of growth however reportedly have a more aggressive behavior, 8 with distant metastases despite the absence of lymph node involvement and poor 5-year overall survival. 6,[9][10][11][12][13] Adenoid cystic carcinoma, especially when showing a predominant tubular-cribriform growth pattern, shares many histological features with infiltrating cribriform and tubular carcinoma.…”

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confidence: 99%

Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast

et al. 2005

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Adenoid cystic carcinoma of the breast represents a unique clinicopathologic entity with a variable histological appearance and a relatively indolent clinical course in most of the cases. Adenoid cystic carcinoma may be difficult to differentiate from infiltrating duct carcinomas, and in particular from tubular and cribriform carcinomas, especially in core or vacuum-assisted biopsies. We evaluated the prevalence of c-kit, p63, and e-cadherin immunoreactivity in a series of 20 adenoid cystic carcinomas, comparing the results with those obtained in a series of infiltrating tubular carcinomas and infiltrating cribriform carcinomas. The hormone receptor status, proliferation labeling index, and HER/2 immunoreactivity had been previously investigated in all the cases. Three (15%) adenoid cystic carcinomas and all infiltrating tubular and cribriform carcinomas showed estrogen receptor and/or progesterone receptor immunoreactivity (Po0.00001 for estrogen and P ¼ 0.00002 for progesterone receptors). Adenoid cystic carcinomas consistently lacked any immunoreactivity for HER/2, whereas three (15%) infiltrating and cribriform carcinomas showed weak and incomplete membrane staining (P ¼ 0.23077). Membranous immunoreactivity for c-kit was found in all except one (predominantly basaloid) adenoid cystic carcinomas (95%), and in none of the infiltrating tubular and cribriform carcinomas (Po0.00001). Nuclear immunoreactivity for p63 was found in all except three (predominantly basaloid) adenoid cystic carcinomas (85%) and in none of the infiltrating tubular and cribriform carcinomas (Po0.00001). All infiltrating tubular and cribriform carcinomas and 18/20 (90%) adenoid cystic carcinomas showed immunoreactivity for e-cadherin (P ¼ 0.48718). In summary, adenoid cystic carcinomas showed the following phenotype: estrogen receptorþ (two cases, 10%), and estrogen receptor þ /progesterone receptor À /c-kit þ /p63 þ (one case). By contrast, all the infiltrating tubular and cribriform carcinomas showed the estrogen receptor þ /progesterone receptor þ /c-kit À /p63 À phenotype. Our data provide evidence that immunoreactivity for c-kit and/or p63 may be useful in differentiating adenoid cystic carcinomas from other types of breast cancer.

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confidence: 99%

Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast

et al. 2005

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“…[3,4] Herzberg et al reported metastatic adenoid cystic carcinoma kidney after 12 years of mastectomy for adenoid cystic carcinoma breast. [3] Awakura et al diagnosed metastatic adenoid cystic carcinoma kidney 5 years after parotidectomy for adenoid cystic carcinoma. Four years after left renal nephrectomy, [4] multiple metastases were demonstrated in the other kidney, liver, lungs and brain by CT scan.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] It is a slowgrowing, but aggressive neoplasm with a remarkable capacity for recurrence. [9,10] It can arise in any salivary gland site, but approximately 50-60% develops within the minor salivary glands.…”

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Parotid Metastatic To Kidney Presenting With Isolated Renal Mass Masquerading As Renal Cell Carcinoma- A Rare Case Report

Khanna¹,

Kaur²,

Singh³

et al. 2017

AIMDR

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Adenoid cystic carcinoma is a rare tumour accounting for less than 1% of all head and neck malignancies and 10% of all salivary gland neoplasms. 50% of cases have been found in minor salivary glands but are also reported in nose, sinuses, upper airway, lacrimal glands and breast. Those affected are in the age group 20-84 years (mean 52 years). Adenoid cystic carcinoma of the head and neck is relatively rare and is characterized by slow evolution, multiple recurrences, protracted clinical course, and late distant metastasis but frequently metastasizes to lung. Here, we are presenting a rare case of adenoid cystic carcinoma metastasizing to kidney and masquerading clinically and radiologically as primary renal cell carcinoma. Lymph node metastases are unusual, hematogenous spread, often to the lungs is quite characteristic, metastasis to kidney being extremely rare.

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“…4 Furthermore, renal medullary carcinoma and mucinous tubular and spindle cell carcinoma entity that exhibits significantly worse outcome than luminal type carcinomas. 6,8 It is then paradoxical that ACC of the breast which is immunophenotypically classified as basal cell type cancer, have been particularly associated with favorable outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Only several cases with high grade tumors and distant metastases have been published, and only one case with symptomatic metastasis to the kidney has previously been reported. 4 We report here a case of ACC of the breast with symptomatic renal metastasis, and for the first time show coexistent mutations in genes encoding phosphoinositide-3-kinase catalytic alpha subunit (PIK3CA) and phosphatase and tensin homolog (PTEN). Both PIK3CA and PTEN are integral part of the mammalian target of rapamycin (mTOR) signaling pathway.…”

Section: Introductionmentioning

confidence: 96%

PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney

Vranić¹,

Bilalović²,

Lee³

et al. 2007

Human Pathology

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Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management

Cited by 46 publications

References 16 publications

Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast

Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast

Adenoid Cystic Carcinoma of Parotid Metastatic To Kidney Presenting With Isolated Renal Mass Masquerading As Renal Cell Carcinoma- A Rare Case Report

PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney

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