Adenoid cystic carcinoma of hard palate with coincidental metastases to lung and liver

Abstract

Adenoid cystic carcinoma is the most frequent pathology occurring in the minor salivary glands .It is usually slow growing; however, it can spread via perineural invasion, haematogenous and lymphatogenous metastasis. Most common sites of metastasis are lung and bone. Involvement of the other sites is not common. In this article, we present a woman with coincident lung and liver metastases.

Persistent pain and swelling after tooth extraction: A masquerade of adenoid cystic carcinoma

“…Even though lungs are recognized as the organs of propensity for distant metastases, spread to bone, brain, and hepatic tissues have been also been noted in few cases. 10,14 In our case no such distant metastasis was seen.…”

“…Haematogenous metastasis is more common than lymphatogenous metastasis .The common sites of metastasis are lung and bones; however, involvement of other organs such as liver is not common. 10,11 AdCC arising from the minor salivary glands are often advanced at the time of diagnosis, and complete excision is limited by their large size (with perineural extension involving the cranial base) and the proximity of the tumor to important neural and vascular structures. 10 A 1:1 sex ratio is commonly noted with slight more inclination towards female population.…”

“…10,11 AdCC arising from the minor salivary glands are often advanced at the time of diagnosis, and complete excision is limited by their large size (with perineural extension involving the cranial base) and the proximity of the tumor to important neural and vascular structures. 10 A 1:1 sex ratio is commonly noted with slight more inclination towards female population. 12 Adenoid cystic carcinoma is more common in 5 th to 6 th decade of life.…”

“…Literatures show association of Adenoid cystic carcinoma (AdCC) and oral squamous cell carcinoma are with history of extraction\ minor surgical procedure. 2,3,5,7,9,10,12,[16][17][18][19][20][21][22] There are instances when after tooth extraction carcinoma appears to develop rapidly and it proliferate up out of the socket, which could probably be due to the unobstructed growth of the neoplastic tissue along the periodontal ligament and sudden proliferation after extraction. Standard treatment AdCC so far consists of complete surgical resection preferably, followed by adjuvant irradiation in case of close margins, perineural invasion, extensive primary tumor (T3, T4) or high-grade histology.…”

Adenoid Cystic Carcinoma of the Submandibular Gland, Locoregional Recurrence, and a Solitary Liver Metastasis More Than 30 Years Since Primary Diagnosis

“…Though rare, there is an increasing frequency of reported cases of ACCs either first presenting with hepatic metastatic disease [ 7 – 9 ] or of distant metastases that have arisen at variable times since primary diagnosis [ 10 – 12 ]. There is no consensus regarding optimal treatment.…”