Adenoid cystic carcinoma of bartholin's gland: Review of the literature and report of two cases

Abräo, Fauzer Simäo; Marques, Andréa Grano; Marziona, Francisco; Abrão, Maurício Simões; Junqueira, Luis C. Uchoa; Torloni, Humberto

doi:10.1002/jso.2930300215

Cited by 24 publications

(9 citation statements)

References 18 publications

(3 reference statements)

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“…The tumor has a remarkable similarity to certain adenocarcinomas of the breast. In fact, some authors have reported that ACC is indistinguishable from ACC of the breast and vulva [1,2]. No standard histologic parameters have proven to be reliable markers of local recurrence or distant metastases in cases of ACC.…”

Section: Introductionmentioning

confidence: 99%

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Barrera

Shroyer

Said

et al. 2007

Head and Neck Pathol

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Objectives The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer. Study Design ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens. Methods Formalin-fixed paraffin-embedded tissues from 47 ACC specimens and 47 samples of normal salivary gland tissue were evaluated histochemically for the presence of ER, PR and p53. Immunoreactivity was scored using a 0 to +3 scale in which staining was either (0) negative, (+1) spotty, (+2) weakly positive, or (+3) strongly positive. Results ER was expressed in 8 of 47 tumors while PR was expressed in 4 of 47 tumors. p53 aberrations were demonstrated in 26 of 47 tumors. Tumors showed varying degrees of immunopositivity ranging from 0 to +3. Conclusions These studies suggest that p53 aberrations may be involved in ACC tumor progression and that ER and PR may play a role in ACC development.

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Section: Introductionmentioning

confidence: 99%

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Barrera

Shroyer

Said

et al. 2007

Head and Neck Pathol

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“…Data is lacking for the role of chemotherapy and biological treatment of BG-ACC. Few studies have trialled 5-fluorouracil, adriamycin, cyclophosphamide, cisplatin, CPT-11 (Irinotecan), methotrexate, and doxorubicin with varying efficacy [ 17 – 20 ]. A single patient trial of adjuvant Tamoxifen on metastatic BG-ACC delayed disease progression for 4 years while maintaining quality of life [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Adenoid Cystic Carcinoma Mimicking a Bartholin Cyst and Literature Review

Goh

McCully

Wagner

2018

Case Reports in Obstetrics and Gynecology

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Adenoid cystic carcinoma of the Bartholin Gland (BG-ACC) is a rare form of vulval cancer with only approximately 350 reported cases since 1864. A review of available literature and case reports suggests an aggressive nature with protracted clinical symptoms and a tendency for local recurrence despite adequate surgical excision with or without adjuvant radiotherapy. Survival rates of 71% and 59% are reported at five and ten years. This case report endeavours to add to our body of knowledge regarding this rare disease and thus help broaden and improve our understanding of management and treatment success.

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“…Previous management of lung metastasis showed that surgery alone was not sufficient [4]. Several chemotherapeutic regimens have been reported in the literature but the use of cyclophosphamide, adriamycin and cisplatin seems most common [4,11]. …”

Section: Discussionmentioning

confidence: 99%

Brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma: a case report

et al. 2013

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IntroductionAdenoid cystic carcinoma of Bartholin’s gland is a very rare disease.Case presentationA 48-year-old premenopausal woman of Caucasian origin was delivered adjuvant pelvic and inguinal radiotherapy after prior complete left Bartholin’s gland tumor excision and inguinal lymph node dissection for adenoid cystic carcinoma of Bartholin’s gland with one metastatic inguinal lymph node.Two years after primary treatment, she presented to the Emergency Room with acute headache, hypoacousia, decrease in visual acuity, and a decrease in right leg muscle strength. A cranial magnetic resonance imaging scan demonstrated three cystic brain lesions with associated perifocal edema. Chest and abdomen computed tomography scans and a magnetic resonance imaging scan of the pelvis did not find any metastatic or residual disease elsewhere. A physical examination found no local recurrence.Stereotactic brain biopsies with pathology examination revealed the presence of adenoid cystic carcinoma metastasis. She thus received 30Gy of brain radiotherapy but, three months later, the brain lesions did not decrease in size and left mid lobular lung lesions appeared on her chest computed tomography scan. A mid left lobe lung excision was undertaken followed by chemotherapy consisting of six cycles of cyclophosphamide, adriamycin and cisplatin. Five months after beginning chemotherapy, the brain disease progressed and our patient died.ConclusionOur case report shows the difficulty in managing brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma as no consensus on the optimal treatment exists.

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Adenoid cystic carcinoma of bartholin's gland: Review of the literature and report of two cases

Cited by 24 publications

References 18 publications

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

A Case of Adenoid Cystic Carcinoma Mimicking a Bartholin Cyst and Literature Review

Brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma: a case report

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