Adenocarcinoma of the uterine cervix

Moberg, Peter; Einhorn, Nina; Silfverswärd, Claes; Söderberg, G.

doi:10.1002/1097-0142(19860115)57:2<407::aid-cncr2820570239>3.0.co;2-2

Cited by 56 publications

(19 citation statements)

References 14 publications

(2 reference statements)

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“…This may be related to limited number of node-positive patients with adenocarcinoma of cervix. In some studies, similarly, a higher incidence of lymph node metastasis and decreased survival in adenocarcinoma compared to squamous cell carcinoma was reported when stage and tumor size were controlled (13,15,25) . In analysis of patients with metastatic lymph nodes, which included 111 with squamous cell carcinoma and 17 with adenocarcinoma, any statistically significant difference was found in survival between two cell types.…”

Section: Discussionmentioning

confidence: 86%

A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

Al¹,

Baykal²,

Demirtas³

et al. 2004

Int J Gynecol Cancer

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Objectives: The objective of this study was to compare clinical and pathologic variables and prognosis of FIGO stage IB adenocarcinoma and squamous cell carcinoma of uterine cervix.MethodsA retrospective review was performed of 521 patients with stage IB squamous cell carcinoma and adenocarcinoma of cervix who treated primarily by type 3 hysterectomy and pelvic and/or para-aortic lymphadenectomy at Hacettepe University Hospitals between 1980 and 1997.ResultsAge, tumor size, grade, depth of invasion, lymph node metastasis, parametrial, vaginal, and lymphvascular space involvement (LVSI) were not different between two cell types except number of the lymph nodes involved. Metastasis to three or more lymph nodes was significantly higher in adenocarcinoma. Overall and disease-free survival were 87.7%, 84.0% versus 86.4%, 83.1% for squamous cell carcinoma and adenocarcinoma, respectively (P > 0.05). The rate and site of recurrence were not different between two cell types. Multivariate analysis of disease-free and overall survival revealed independent prognostic factors as tumor size, LVSI, number of involved lymph node, and vaginal involvement.ConclusionPrognosis of FIGO stage IB cervical cancer patients who were treated by primarily radical surgery was found to be same for those with adenocarcinoma and squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 86%

A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

Al¹,

Baykal²,

Demirtas³

et al. 2004

Int J Gynecol Cancer

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“…Investigations comparing the prognosis of cervical AD with SCC came up with varying results, with certain studies reporting AD to have a poorer prognosis compared to SCC (7-11) and others reporting no statistically significant differences between the two (12)(13)(14)(15)(16). Lymph node metastasis is commonly more aggressive in AD compared to SCC and some studies reported a higher incidence of lymph node metastasis and poorer prognosis in AD compared to SCC after controlling for stage and tumor size (22)(23)(24). However, although the rates of lymph node metastasis in our AD group (19%) and SCC group (12.9%) did not differ significantly, AD was significantly associated with a worse prognosis compared to SCC in all patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of outcomes between squamous cell carcinoma and adenocarcinoma in patients with surgically treated stage I–II cervical cancer

Yamauchi

Fukuda

Wada

et al. 2014

Molecular and Clinical Oncology

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“…In a recently published prospective trial, significantly improved recurrence‐free and overall survival rates were noted for stage IB and IIA cervical adenocarcinoma patients who had radical hysterectomy and pelvic lymphadenectomy compared with those who received radiotherapy ( 28 ) . Some observed comparable results with either primary surgery or radiation ( 17 ) , while the others advocated combined treatment ( 29 ) .…”

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confidence: 99%

Are adenocarcinomas and adenosquamous carcinomas different from squamous carcinomas in stage IB and II cervical cancer patients undergoing primary radical surgery?

Lai¹,

Hsueh²,

Hong³

et al. 1999

Int J Gynecol Cancer

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The aim of this study was to define clinicopathologic features and to investigate prognostic factors in early-stage cervical adenocarcinomas and adenosquamous carcinomas in patients undergoing primary radical surgery. One hundred thirty-four patients with stage IB or II cervical adenocarcinoma or adenosquamous carcinomas treated at a single institution were reviewed and compared to squamous carcinomas (N = 757) treated in the same period. Among adeno-adenosquamous carcinomas, stage II disease, parametrial extension, and deep cervical stromal invasion (>2/3) were associated with increased risk of pelvic lymph node metastases, while only clinical stage II, DNA index >1.3 (by flow cytometry), and pelvic node metastases were significantly associated with decreased survival by multivariate analyses. The five-year recurrence-free and overall survival rates of patients with adeno-adenosquamous vs squamous carcinoma were 72.2% vs 81.2% (P = 0.0109), and 74.1% vs 82.8% (P = 0.0136), respectively by Mantel-Cox test. After controlling confounding factors, histologic type (adeno-adenosquamous vs squamous) was confirmed as an independent prognostic factor for recurrence-free survival [relative risk (RR): 1.2792; 95% confidence interval (CI): 1.0628-1.5399, P = 0.0092) and overall survival (RR: 1.2594, 95% CI: 1.0467-1.5155, P = 0.0146) in the whole series (N = 891). Although pattern of relapse by histologic type was not significantly different, patients with recurrent adeno-adenosquamous carcinoma did significantly worse than those with recurrent squamous carcinoma. In conclusion, the prognosis of adeno-adenosquamous carcinoma of the cervix is slightly worse than squamous tumors. Since salvage of recurrent adeno-adenosquamous carcinoma after primary radical surgery is generally ineffective using conventional treatment, innovative strategies are necessary for the high-risk group after primary surgery and all recurrent adeno-adenosquamous carcinomas regardless of size or site.

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Adenocarcinoma of the uterine cervix

Cited by 56 publications

References 14 publications

A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

Comparison of outcomes between squamous cell carcinoma and adenocarcinoma in patients with surgically treated stage I–II cervical cancer

Are adenocarcinomas and adenosquamous carcinomas different from squamous carcinomas in stage IB and II cervical cancer patients undergoing primary radical surgery?

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