Adenocarcinoma of the third portion of the duodenum in a man with CREST syndrome

Anastasopoulos, Georgios; Marinis, Athanasios; Konstantinidis, Christos; Theodosopoulos, Theodosios; Fragulidis, Georgios P.; Vassiliou, Ioannis

doi:10.1186/1477-7819-6-106

Cited by 8 publications

(8 citation statements)

References 11 publications

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“…The most common malignancy to the duodenum is adenocarcinoma, which usually (a) arises in the second part of the duodenum, (b) develops in the seventh decade of life, and (c) causes abdominal pain, weight loss, nausea, vomiting, jaundice and/or haemorrhage 2 4 9. Incidence of adenocarcinoma in the small bowel is greatest in the duodenum (55%), followed by the jejunum (18%) and the ileum (13%) 3. The frequency of adenocarcinomatous lesions in the duodenum is 15% in the first part, 40% in the second and 45% in the third and fourth 3 10.…”

Section: Discussionmentioning

confidence: 98%

“…Incidence of adenocarcinoma in the small bowel is greatest in the duodenum (55%), followed by the jejunum (18%) and the ileum (13%) 3. The frequency of adenocarcinomatous lesions in the duodenum is 15% in the first part, 40% in the second and 45% in the third and fourth 3 10. These aggressive tumours are reported to have a 5-year survival rate of 25%; however, radical excision improves this to 54% 11 12.…”

Section: Discussionmentioning

confidence: 99%

“…Adenocarcinoma and carcinoid tumours are the most common histological type of primary malignant tumours of the small bowel 2. In the small bowel, adenocarcinoma most commonly arises in the duodenum (55%), followed by the jejunum (18%) and the ileum (13%) 3. Metastatic lesions to the duodenum are a rare occurrence.…”

Section: Introductionmentioning

confidence: 99%

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Endoscopic biopsies of duodenal polyp/mass lesions: a surgical pathology review

et al. 2010

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Endoscopic biopsies of duodenal polyp/mass lesions: a surgical pathology review

et al. 2010

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“…Most of these neoplasms are asymptomatic until they enlarge. The most common clinical manifestations are abdominal pain (epigastralgia), anemia, weight loss, jaundice, obstruction, bleeding or melena [5]. However, a very infrequent disease like duodenal adenocarcinoma with non-specific symptoms and signs may be associated with a delayed diagnosis and poor prognostic and survival outcomes [6].…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary duodenal bulb and cecal adenocarcinoma: case report and short review of the literature

et al. 2012

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Background: Primary duodenal adenocarcinoma is a rare entity with an uncertain biologic behaviour whose diagnosis is usually achieved by endoscopy and biopsy. However, it lacks specific symptoms and its diagnosis may be delayed with poor prognosis. Villous adenomas are considered as premalignant lesions with high risk malignant transformation.Methods: We report a rare case of a patient with two synchronous adenocarcinomas, one of the first portion of the duodenum as a villous tumor and the other in cecum colon. The patient submitted successfully to pacreatoduodenectomy and right hemicolectomy, while postoperatively received also adjuvant chemotherapy.Results: Seventeen months after the operations the patient is alive with no evidence of recurrent or metastatic disease.Conclusions: The radical resection of primary duodenal adenocarcinoma is considered the treatment of choice, which should be accompanied by adjuvant chemotherapy preventing a recurrence at distant sites.

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“…CREST syndrome is rarely associated with other malignancies (69). It has been suggested that patients with scleroderma and Barrett's metaplasia are at increased risk of complications, such as strictures or adenocarcinoma, cases of CREST syndrome and lung adenocarcinoma, esophageal carcinoma, and adenocarcinoma of the third portion of the duodenum (41,69).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

CREST Syndrome - a Limited Form of Systemic Scleroderma: a Case Report and Literature Review

Paravina

Stanojević

Spalević

et al. 2015

Serbian Journal of Dermatology and Venereology

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Systemic scleroderma (SSc) is a multisystem disease with microvascular abnormalities, autoimmune disorders, excessive collagen production and deposition, and fibrosis of the skin and internal organs. According to the simplest, though incomplete classification, there are two forms of SSc: diffuse and limited (formerly acrosclerosis). CREST syndrome is a subtype of limited SSc, characterized by: calcinosis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. We present a patient with all the features of the CREST syndrome, which appeared at the age of 43 and lasted for 23 years. The patient presented with a gradual development of symptoms during the first ten years, from Raynaud’s phenomenon, skin sclerosis, calcinosis, telangiectasia, and esophageal dysmotility. The diagnosis was based on clinical findings and relevant diagnostic procedures. The article presents a literature review on the epidemiology, etiology, pathophysiology, clinical manifestations, various attempts at classification, diagnostic criteria, and therapeutic modalities. When classifying systemic scleroderma into two main types — diffuse and limited, with CREST syndrome as a variant of the latter, it should be pointed out that both types represent clinical forms of systemic sclerosis, share similar visceral involvement, laboratory abnormalities and course which is variable, as was the case in our patient.

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Adenocarcinoma of the third portion of the duodenum in a man with CREST syndrome

Cited by 8 publications

References 11 publications

Endoscopic biopsies of duodenal polyp/mass lesions: a surgical pathology review

Endoscopic biopsies of duodenal polyp/mass lesions: a surgical pathology review

Synchronous primary duodenal bulb and cecal adenocarcinoma: case report and short review of the literature

CREST Syndrome - a Limited Form of Systemic Scleroderma: a Case Report and Literature Review

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