Adenocarcinoma of the third and fourth portion of the duodenum: a case report and review of the literature

Abstract

A 65-year-old woman presented with abdominal pain, weight loss, fatigue, and microcytic anemia. Esophagogastroduodenoscopy, until the second part of duodenum, was normal. Ultrasound and computed tomography demonstrated a solid mass in the distal duodenum. A repeat endoscopy confirmed an ulcerative, intraluminar mass in the third and fourth part of the duodenum. Segmental resection of the third and fourth portion of the duodenum was performed. Histology revealed an adenocarcinoma. On the 4 th postoperative day, the patient developed severe acute pancreatitis leading to multiple organ failure and died on the 30 th postoperative day.

Primary Duodenal Adenocarcinoma without Stenosis: A Case Report with a Brief Literature Review

“…Moreover, it is responsible for only 1% of deaths due to gastrointestinal neoplasms [2, 4]. Approximately 30–50% of small intestinal adenocarcinomas occur in the duodenum [5].…”

Endoscopic biopsies of duodenal polyp/mass lesions: a surgical pathology review

“…Malignant tumours of the duodenum are extremely uncommon, with primary cancers of the duodenum representing 0.3% of all gastrointestinal tumours 2 4. The most common malignancy to the duodenum is adenocarcinoma, which usually (a) arises in the second part of the duodenum, (b) develops in the seventh decade of life, and (c) causes abdominal pain, weight loss, nausea, vomiting, jaundice and/or haemorrhage 2 4 9. Incidence of adenocarcinoma in the small bowel is greatest in the duodenum (55%), followed by the jejunum (18%) and the ileum (13%) 3.…”

“…Benign duodenal neoplasms, such as Brunner's adenoma, are uncommon and found only in 0.3–4.6% of patients at oesophagogastroduodenoscopy (OGD) 1. Only 1% of all gastrointestinal malignancies are located in the small intestine, with duodenal adenocarcinomas representing 0.3% 2. Adenocarcinoma and carcinoid tumours are the most common histological type of primary malignant tumours of the small bowel 2.…”

“…Only 1% of all gastrointestinal malignancies are located in the small intestine, with duodenal adenocarcinomas representing 0.3% 2. Adenocarcinoma and carcinoid tumours are the most common histological type of primary malignant tumours of the small bowel 2. In the small bowel, adenocarcinoma most commonly arises in the duodenum (55%), followed by the jejunum (18%) and the ileum (13%) 3.…”

Through the keyhole: Radiological management of malignant gastric outflow obstruction beyond the pylorus

“…More distal levels of obstruction (e.g., 4th part of duodenum, proximal jejunum) may prove difficult to access with standard endoscopy equipment. 7 Of these options the placement of a SEMS is currently the most frequently undertaken. 6 SEMS insertion is most likely to be carried out endoscopically with fluoroscopic assistance.…”