Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases

Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma

“…2 Carcinomas originating from the mucosa of the small intestines, including the duodenum, jejunum, and ileum, were included in our present study. Carcinomas extending from the surrounding gastrointestinal tract organs, such as the stomach, ampulla of Vater, pancreas, cecum, or appendix, into the small intestines were excluded from the analysis.…”

“…1 Despite recent improvements in the detection of the small intestinal adenocarcinomas, including improved imaging techniques and endoscopic modalities, the diagnosis of small intestinal adenocarcinomas is usually made at an advanced clinical stage and the 5-year survival rate is only 41.2%. 2 Several clinicopathologic factors, including lymph node metastasis and the distal locations of these tumors (jejunum and ileum), are known as the most important independent prognostic factors. 2 Although several molecular alterations, including KRAS, TP53, and DPC4/SMAD4 mutations and the overexpression of cyclinD1, are known to be involved in small intestinal adenocarcinoma carcinogenesis, [3][4][5][6] only a few of these, such as b-catenin and e-cadherin, demonstrate prognostic implications for small intestinal adenocarcinoma patients.…”

“…2 Several clinicopathologic factors, including lymph node metastasis and the distal locations of these tumors (jejunum and ileum), are known as the most important independent prognostic factors. 2 Although several molecular alterations, including KRAS, TP53, and DPC4/SMAD4 mutations and the overexpression of cyclinD1, are known to be involved in small intestinal adenocarcinoma carcinogenesis, [3][4][5][6] only a few of these, such as b-catenin and e-cadherin, demonstrate prognostic implications for small intestinal adenocarcinoma patients. 7 Mucins are large filamentous glycoproteins that heavily glycosylate many of the oligosaccharide side chains that are linked to the protein backbone called apomucin.…”

Small Bowel Adenocarcinoma – Report of Two Cases and Review of Literature

“…The duodenum accounted for 50 % and ileum 12 % of tumors [9]. Another multi-institutional study documenting 197 cases of small bowel adenocarcinomas found that around 30 % of these lesions were present in the jejunum [10]. A review of 69 patients with primary small bowel tumors over a 15-year period showed the incidence of jejunal lesions to be 41 % with a 5-year survival of 34.28 % [5].…”

“…Also, lymph node metastasis and distal location (jejunum and ileum) were independent predictors for a worse prognosis [10]. For patients who underwent resection, reduced performance status, higher stage, and residual disease after resection predicted overall survival [9].…”