Adenocarcinoma of the Scrotum (Extramammary Paget’s Disease): Case Report and Review of the Literature

Hoch, William H.

doi:10.1016/s0022-5347(17)49501-2

Cited by 22 publications

(6 citation statements)

References 6 publications

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“…The lesions start on the scrotum, the penis or the inguinal folds and may spread to the abdomen; rarely, they are limited to the glans penis. Inguinal lymph node enlargement may be present, 60 occasionally associated with oedema of the legs, and may be inaugural. Association with an underlying carcinoma (of the prostate, bladder, testicles, ureter, kidney) occurs in 11% of cases 61 …”

Section: Extramammary Paget's Diseasementioning

confidence: 99%

Mammary and extramammary Paget's disease

Kanitakis

2007

Acad Dermatol Venereol

274

287

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Paget's disease is an intra-epidermal adenocarcinoma seen over the nipple/areola (mammary Paget's disease) or in extramammary body zones, such as the anogenital and perineal skin and the axilla. Mammary and extramammary Paget's disease share many common clinicopathological features but also show several differences, namely, with regard to pathogenesis and association with underlying malignancies. Indeed, mammary Paget's disease is as a rule associated with an underlying breast carcinoma whereas association of extramammary Paget's disease with underlying (skin or visceral) malignancies occurs much less frequently. We review here the main clinicopathological and therapeutic features of mammary and extramammary Paget's disease.

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Section: Extramammary Paget's Diseasementioning

confidence: 99%

Mammary and extramammary Paget's disease

Kanitakis

2007

Acad Dermatol Venereol

274

287

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“…EMPD generally presents as a 'resistant' eczematous lesion in patients between 50 and 80 years of age. 5 Histopathologically, EMPD is characterized by Paget's cells, which have abundant pale-staining cytoplasm and large atypical nuclei, appearing singly or in clusters. 3 Areas with a high density of apocrine glands, namely the penoscrotal area in men and the vulva in women are sites of predilection.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Local control and prognosis of patients with EMPD are related to the presence of adnexal and visceral malignancy as well as to the extent of metastatic spread. 5 Histopathologically, EMPD is characterized by Paget's cells, which have abundant pale-staining cytoplasm and large atypical nuclei, appearing singly or in clusters. Treatment of EMPD is sometimes difficult because of its tendency to be multifocal.…”

Section: Introductionmentioning

confidence: 99%

Extramammary Paget's disease: outcome of radiotherapy with curative intent

Luk

Yu²,

Yeung³

et al. 2003

Clinical and Experimental Dermatology

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Six patients with extramammary Paget's disease were treated with curative intent radiotherapy. Two of the patients had associated underlying adenocarcinoma. Radiotherapy was given as primary treatment (two patients), definitive treatment for postexcisional relapse (three patients) and adjuvant treatment (one patient). Radiotherapy techniques included high dose rate mould brachytherapy, electron beam, superficial X-ray and photon treatments. Follow-up durations after radiotherapy were 1.2-14.8 years. Complete response was obtained in five patients while one patient had a partial response. Marginal failure occurred in one complete-responder who was successfully salvaged by surgery. The two patients with underlying adenocarcinoma died of distant metastasis. Radiotherapy side effects were acute confluent wet desquamation and mild late skin atrophy. Our results confirmed the useful role of radiotherapy in the management of extramammary Paget's disease.

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“…. 31 The literature review shows that radiation therapy is an effective and well-tolerated treatment with good local control.…”

Section: Discussionmentioning

confidence: 99%

Paget'sdisease of scrotum and peniscase report of a re‐irradiation and review of the literature

Piras¹,

Sanfratello

Boldrini

et al. 2020

Dermatologic Therapy

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Extramammary Paget's disease (EMPD) is a rare cutaneous adenocarcinoma generally arising in the anogenital region. Surgery is still considered the treatment of choice for patients with EMPD, while Radiotherapy is a common alternative for inoperable cases and it's necessary in case of lack of surgical radicality. In this article, we described our experience and a review of the literature, with a particular focus on radiation-induced toxicity and on the feasibility of re-irradiation. A 70-year-old patient with EPMD underwent adjuvant radiotherapy in 2015. After 28 months for recurrence another radiant treatment was performed. No G3 (CTCAE v4) toxicity were recorded. In the last follow-up visit at 18 months, no signs of relapse were reported. A search strategy of the bibliographic database PubMed was performed. The inclusion criteria for the articles were case report, clinical prospective, or retrospective studies with histological confirmation of EMPD of scrotum and penis; studies with patients undergoing RT; studies in the past 30 years. In most of the 14 reported studies, RT was overall well tolerated. The major observed toxicity was G3 skin toxicity in one study. To our knowledge, there are no other cases of EPMD re-irradiation in literature. Our patient showed an excellent response and tolerated very well the high doses of both the radiation treatments. This suggests that the tolerance of skin to re-irradiation following a long period between the two treatments may be comparable to the normal constraints.

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Adenocarcinoma of the Scrotum (Extramammary Paget’s Disease): Case Report and Review of the Literature

Cited by 22 publications

References 6 publications

Mammary and extramammary Paget's disease

Mammary and extramammary Paget's disease

Extramammary Paget's disease: outcome of radiotherapy with curative intent

Paget'sdisease of scrotum and peniscase report of a re‐irradiation and review of the literature

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