Adenocarcinoma of the Rectum in Patients Under Age 40 Is Increasing

Tawadros, Patrick S.; Paquette, Ian M.; Hanly, Ann; Mellgren, Anders; Rothenberger, David A.; Madoff, Robert D.

doi:10.1097/dcr.0000000000000318

Cited by 65 publications

(39 citation statements)

References 10 publications

(8 reference statements)

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“…In agreement with previous colorectal SRCC data, 4 , 5 , 7 – 9 colorectal MAC-SRC patients were commonly diagnosed at an advanced stage in this study, with distant metastasis or lymph node metastasis. In a previous study examining 59 patients, 58 (98.3%) individuals had T3/T4 lesions, 52 (88.1%) showed lymph node metastasis, and 14 (23.7%) had distant metastasis.…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies demonstrated that colorectal SRCC is more common in younger individuals (≤40-year-old) than non-SRC MAC. 4 , 5 , 7 , 14 The reported mean age of colorectal SRCC patients is 48.1 years, while 57.4 years was found for colorectal MAC. 20 Young age (≤40-year-old) was shown to be an independent predictive factor of disease outcome in a previous study.…”

Section: Discussionmentioning

confidence: 99%

“…However, SRCs are histologically more aggressive due to the absence of cell-to-cell adhesion, which leads to a high tendency of metastasis. 7 , 9 , 19 The reported incidence of peritoneal metastasis in colorectal SRCC is 38%, with a combined rate at other sites, including the liver, lung, bone, and brain, of only 18.5%. 4 Additionally, colorectal tumors with <50% SRCs have a predisposition (75.0%) to metastasize to the peritoneum and ovaries.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Kong

Zhang

Huang

et al. 2017

CMAR

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BackgroundColorectal signet ring cell (SRC) carcinoma occurs rarely with a poor prognosis. The present study assessed the prognostic factors and predictive value of SRC ratio in colorectal mucinous adenocarcinoma (MAC) with SRCs (MAC-SRC).Patients and methodsA total of 95 consecutive colorectal MAC-SRC patients, confirmed pathologically from February 1987 to December 2015, were analyzed retrospectively in our institute. Clinical characteristics, pathological grade, TNM staging, and SRC ratio were assessed to identify the prognostic factors related to progression-free survival (PFS) and overall survival (OS). SPSS 22.0 was used for statistical analyses.ResultsThe median follow-up time was 29.7 months (range 0.8–165). Meanwhile, 5-year PFS and OS rates were 25.6% (95% confidence interval [CI] 16.192–35.008%) and 40.5% (95% CI 29.524–51.476%), respectively. Among the 81 patients who underwent surgery, 78 (96.3%) were diagnosed as stage T3 or T4; 74 (91.4%) showed lymph node involvement, and 27 (29.3%) presented distant metastasis. Metastases of the peritoneal cavity and ovaries were observed commonly in colorectal MAC-SRC. In the multivariate Cox regression model, SRC ratio ≥35%, absence of preoperative radiotherapy, and distant metastasis were independent predictors of PFS. Furthermore, SRC ratio ≥35%, absence of preoperative chemotherapy (pre-CT), and distant metastasis were independent risk factors for poor prognosis.ConclusionA long-term follow-up of colorectal MAC-SRC reveals that it is a rare subtype of colorectal MAC with a dismal prognosis. Furthermore, SRC ratio, pre-CT, and M stage seem to affect OS independently.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Kong

Zhang

Huang

et al. 2017

CMAR

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“…Ancak rektal kanser için 40 yaş altı bireylerde de artan insidans oranı bildirilmektedir. 19 Ülkemizde ise Türkiye Halk Sağlığı Kurumu'nun 2014 yılı verilerine göre dünya istatistikleri ile benzer şekilde kolorektal kanserin tüm yaş grupları içinde kadın ve erkek bireylerde en sık görülen üçüncü kanser türü olduğu belirtilmiştir. 20 Birçok risk faktörü kolorektal kanser ile ilişkilidir.…”

Section: Kolorektal Kanser Epi̇demi̇yoloji̇si̇ Eti̇yoloji̇si̇ Ve Ri̇sk Faktöunclassified

Different Mechanisms and the Role of Nutrition in the Formation of Colorectal Cancer

Atabilen¹,

Akbulut²

2019

Turkiye Klinikleri J Med Sci

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anser, ekonomik açıdan gelişmişlik derecesine bakılmaksızın toplumlar üzerinde büyük bir yük oluşturmaktadır. Özellikle günümüzde toplumların yaşlanma sorunuyla karşı karşıya kalmaları ve obezite, fiziksel inaktivite gibi risk faktörleri prevalansındaki artış kanser oluşum hızını artırmaktadır. Global kanser istatistikleri (GLOBOCAN) 2012 yılında dünyada 14,1 milyon yeni kanser vakası ve 8,2 milyon kansere bağlı mortalite oluştuğunu bildirmiştir. 1 Kanserler arasında sıralama yapıldığında

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“…In contrast, MAC are characterized by abundant extracellular mucin produced by tumor cells. MAC share some clinical characteristics with SC, such as occurring in younger patients4,5 and a high propensity for lymph node metastases with low incidence of hepatic metastasis 2,6. What is more, its clinical course is aggressive with a high incidence of local recurrence 4–6.…”

mentioning

confidence: 99%

Role of CT scan in differentiating the type of colorectal cancer

Li¹,

You²,

Gao³

et al. 2017

OTT

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ObjectivesMost colorectal cancers are classical adenocarcinomas (AC), and less frequent subtypes include mucinous adenocarcinomas (MAC) and signet-ring cell carcinomas (SC). The purpose of this study was to evaluate the computed tomography (CT) findings that can help to differentiate MAC and SC from AC.MethodsCT scans of 168 patients with pathologically proven MAC and 67 patients with pathologically proven SC were analyzed, and 220 patients with classical AC were also included as a control group. CT findings of the three groups were compared and contrasted in terms of the bowel involvement patterns, contrast enhancement patterns, and presence or absence of bowel obstruction, intratumoral calcification, pericolic fat infiltration, and local tumor extension to adjacent organs. Statistical analyses were made by using the one-way analysis of variance, least significant difference test, and Pearson’s chi-square test.ResultsCompared with classical AC, the MAC showed more severe (6.29±2.69 cm vs 4.57±1.74 cm, P<0.001) and higher percentage of occurrence of eccentric bowel-wall thickening (37.2% vs 11.5%, P<0.001). Heterogeneous contrast enhancement was most common in MAC (P<0.01), and MAC showed more areas with hypoattenuation (P<0.001). The presence of intratumoral calcification was most frequent in MAC (17.9% vs 2% vs 6.8%) (P<0.001); the SC also were more severe (5.75±2.28 cm vs 4.57±1.74 cm. P=0.001) than AC, but SC tend to show more cases of concentric even bowel-wall thickening (67.2%); homogeneous contrast enhancement was most common in SC (P<0.01), and it showed a target appearance. The presence of peritoneal seeding was most frequent in SC (35.8% vs 8% vs 2.7%, P<0.001), while the presence of regional lymph node metastasis (P=0.190) and direct invasion of adjacent organs or metastasis (P=0.323) were not significantly different among them.ConclusionSome radiological features by CT can be used to classify different colon tumor types.

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Adenocarcinoma of the Rectum in Patients Under Age 40 Is Increasing

Cited by 65 publications

References 10 publications

Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Different Mechanisms and the Role of Nutrition in the Formation of Colorectal Cancer

Role of CT scan in differentiating the type of colorectal cancer

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