Adenocarcinoma of the Lung Presenting with Raynaud's Phenomenon, Digital Gangrene and Multiple Infarctions in the Internal Organs

Paraneoplastic Raynaud’s Phenomenon as an Initial Manifestation of Lung Cancer?

“…Similar cases in the literature include a 54-year-old man with Raynaud's phenomenon and right lung adenocarcinoma, whose symptoms improved after chemotherapy [3] , and a 62-year-old man who sought attention for severe Raynaud's phenomenon and was found to have non-small cell lung cancer, whose symptoms also resolved after chemotherapy [4] . Wilmalaratna et al reported the case of a 69-year-old man who had Raynaud's phenomenon with primary adenocarcinoma of the apex of the left lung [5]. Kopterides et al described a 65-year-old woman with stage IIIB lung adenocarcinoma diagnosed 6 months earlier who developed Raynaud's phenomenon, had to undergo amputation of her fingers for gangrene, and later died of respiratory failure [6] .…”

Severe digital ischemia–a presenting symptom of malignancy–associated antiphospholipid syndrome

“…In some of the patients, Raynaud's phenomenon may remit following surgical excision or chemotherapy. 10 Raynaud's phenomenon has been described in association with a variety of malignancies including lung cancer, [11][12][13][14][15] renal cell carcinoma, 16,17 ovarian adenocarcinoma, 18 testicular cancer, 16 and melanoma. 19 Possible pathophysiologic mechanisms of paraneoplastic Raynaud's phenomenon include cryoglobulinemia, immune complex-induced vasospasm, vasculitis, hypercoagulable state, marantic endocarditis with embolic phenomena, and aPL antibodies.…”

Digitale Ischämie als Paraneoplasie bei metastasierendem Adenokarzinom des Endometrium uteri

“…Die Art und Lokalisation des Tumors kann von großer Variabilität sein: Häufig wurden Adenokarzinome unterschiedlicher Organsysteme (Lunge [20], Intestinaltrakt [12,16,22], Ovarien [6]), aber auch lymphoproliferative Erkrankungen (Mykosis fungoides [10], großzellig anaplastisches Lymphom [15], M. Hodgkin [9]), Karzinoid-Syndrom [14] und malignes Melanom [3] als auslösende Neoplasien identifiziert. Kürzlich wurde über eine digitale Nekrose im Zusammenhang mit Interferon-α und Hydroxyurea bei chronisch myeloischer Leukämie berichtet, wobei Interferon-α die entscheidende Rolle bei der Auslösung der digitalen Nekrosen zugeschrieben wurde [2].…”