Adenocarcinoma of the endometrium in Israel, 1960–1968

Schenker, Joseph G.; Tal, J.

doi:10.1002/1097-0142(19801215)46:12<2752::aid-cncr2820461236>3.0.co;2-m

Cited by 22 publications

(5 citation statements)

References 13 publications

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“…Although Jews of Asian-African origin (Sephardic) make up ∼60% of the Jewish population in the south of Israel, we have noticed more women of European-American origin (Ashkenazi) (61.8%) than those of Asian-African origin (Sephardic) (38.2%) affected by the disease. The same trend has been shown by Schwartz et al [12] for uterine sarcomas in Israel and by Schenker and Tal [21] for endometrial carcinoma in Israel. An increased incidence of uterine sarcomas following radiotherapy to the pelvis for either carcinoma of the cervix or a benign condition has been noticed, and the relative risk of developing uterine sarcoma following pelvic radiotherapy has been estimated to be 5.4 [1,12].…”

Section: Discussionsupporting

confidence: 80%

Uterine sarcoma in the south of Israel: Study of 36 cases

et al. 1997

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Background Uterine sarcomas are rare, characterized by rapid clinical progression and poor prognosis, and their management has been a challenge. The purpose of this study was to investigate the clinical and histologic findings, treatment, and outcome of patients with uterine sarcoma in the south of Israel. Methods Data from the files of 36 patients with uterine sarcoma who were managed at the Soroka Medical Center between January 1961 and December 1994 were evaluated. Results The 5‐year survival rate was 32% overall; 63% for 9 patients with endometrial stromal sarcoma (ESS), 30% for 14 patients with mixed mesodermal sarcoma (MMS) and 18% for 13 patients with leiomyosarcoma (LMS); 41% for 22 patients with Stage I and 19% for 14 patients with Stages II, III, and IV. Only the difference in the 5‐year survival rate between ESS and LMS was statistically significant (P < 0.05). Eleven patients (30.6%) were treated with surgery alone, 4 (11.1%) with surgery followed by pelvic radiotherapy, 11 (30.6%) with surgery followed by chemotherapy, 8 (22.2%) with surgery followed by pelvic radiotherapy and chemotherapy, one (2.8%) with chemotherapy alone, and one (2.8%) had no treatment. Conclusions Uterine sarcomas are aggressive tumors with a poor prognosis. The treatment is surgery generally followed by adjuvant pelvic radiotherapy and/or systemic chemotherapy. J. Surg. Oncol. 64:55–62 © 1997 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 80%

Uterine sarcoma in the south of Israel: Study of 36 cases

et al. 1997

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“…However, height is now considered as an important risk factor for 2 other hormone-related malignancies: breast cancer (De Waard and Trichopoulos, 1988) and prostatic cancer (Severson et al, 1988). Furthermore, studies in migrants indicate that environmental factors critical for the development of endometrial cancer may be operative at a young age, a fact pointing to height, in addition to weight, as an independent risk indicator (Schenker and Tal, 1980;Kelsey and Hildreth, 1983).…”

Section: Discussionmentioning

confidence: 99%

A case‐control study of cancer of endometrium in athens

Koumantaki

Τζώνου

Koumantakis

et al. 1989

Intl Journal of Cancer

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Eighty-three women with invasive adenocarcinoma of the endometrium and 164 control women hospitalized for various orthopedic conditions were interviewed regarding demographic, reproductive, socio-economic and biomedical characteristics, including their use of tobacco, drugs and exogenous estrogens. The data were analyzed by modelling rate ratio (r) through multiple logistic regression. The main results were as follows: women with invasive adenocarcinoma of the endometrium had earlier menarche (r = 0.82 for every additional year; one-tailed p approx. 0.04), later menopause (r = 1.50 for a 5-year difference; one-tailed p approx. 0.004), and fewer live-born children (r = 0.86 for every additional child; one-tailed p approx. 0.08); they were also taller (r = 1.33 for a 5-cm difference; one-tailed p approx 0.03), whereas weight, adjusted for height, was not a statistically significant risk indicator (one-tailed p approx. 0.38). Regular use of combination oral contraceptives was associated with a reduced risk of endometrial cancer (r = 0.56), whereas intake of menopausal estrogens for more than 6 months was associated with an increased risk (r = 2.04); however, because of the low frequency of use of exogenous estrogen preparations in Greece, neither of these 2 results was statistically significant. Tobacco smoking was associated with a significantly reduced risk of endometrial cancer; smoking 15-20 cigarettes per day for 20 years was associated with a rate ratio of 0.49 (one-tailed p approx. 0.03). The protective effect of tobacco smoking was evident only among post-menopausal women. These results indicate that the risk profile of endometrial cancer is similar in high-risk and low-risk countries, and underline the importance of unopposed estrogenic stimulation in the pathogenesis of this cancer.

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“…(Grulich et al, 1996;Schenker et al, 1980). Wie bereits eingangs erwähnt, konnte die prognostische Bedeutung des Tumorgradings aufgrund der geringen Inzidenz von Tumortod nicht aufgezeigt werden, jedoch zeigte sich diesbezüglich ein deutlicher Trend, der ein Abfallen der mittleren Überlebenszeit mit zunehmend schlechtere Tumordifferenzierung herausstellte (mittlere ÜLZ G1+G2 = 19,2 Jahre versus G3 = 13,2 Jahre).…”

Section: Expression Des Progesteronrezeptors Im Tumorgewebeunclassified

Prognosefaktoren des Endometriumkarzinoms - Ein Vergleich klinischer und immunhistochemisch bestimmter Parameter

Brohn¹,

Kullmer²,

Knoblauch³

et al. 2004

Geburtshilfe Frauenheilkd

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In den meisten Fällen erfolgt die Diagnose Endometriumkarzinom in einem frühen, doch auch in ca. 20 % in einem fortgeschrittenen Stadium. Welche tumorbiologischen Eigenschaften führen dazu, dass einige Endometriumkarzinome erst in fortgeschrittenen Stadien entdeckt werden? Material und Methodik: Ein Kollektiv von 183 Patientinnen mit Karzinomen des Endometriums wurde reevaluiert im Hinblick auf das klinische Follow-up sowie der Histopathologie (myometrane Tumorinvasionstiefe, Tumortyp, Grading, Lymphangiosis und Hämangiosis carcinomatosa, Tumornekrose). Zusätzlich erfolgten immunhistochemische Färbungen zur Detektion der Expression von Östrogen-und Progesteronrezeptor, Fibronektin und Faktor VII aktivierende Protease (FSAP) unter Verwendung der Streptavidin-Biotin-Methode. Mithilfe der Kaplan-Meier-Überlebenszeitanalyse wurden die prognostischen Parameter analysiert; bivariate Korrelationen sowie einfache und schrittweise Diskriminanzanalyse ermöglichten die Analyse der Relevanz der genannten Faktoren im Hinblick auf die Tumorprogression. Ergebnisse: Tumorstadium (FIGO) und Hämangiosis carcinomatosa konnten als wichtigste Prognosefaktoren des Endometriumkarzinoms identifiziert werden. Hinsichtlich der o. g. Fragestellung wurde die Lymphangiosis carcinomatosa als wichtigster

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Adenocarcinoma of the endometrium in Israel, 1960–1968

Cited by 22 publications

References 13 publications

Uterine sarcoma in the south of Israel: Study of 36 cases

Uterine sarcoma in the south of Israel: Study of 36 cases

A case‐control study of cancer of endometrium in athens

Prognosefaktoren des Endometriumkarzinoms - Ein Vergleich klinischer und immunhistochemisch bestimmter Parameter

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