Adenocarcinoma of the colon in children: Case series and mini-review of the literature

Al‐Tonbary, Youssef; Darwish, Ahmad; El-Hussein, Ahmad; Fouda, Ashraf

doi:10.1016/j.hemonc.2013.02.003

Cited by 30 publications

(32 citation statements)

References 17 publications

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“…As shown in Supplementary Tables S1 and S2, this is the first prospective Italian cooperative study on GI carcinomas. All the previous studies on GI tract carcinomas in young people in the last 30 years were retrospective single‐institution series concerning only a handful of cases seen over broad periods of time, and most of them concerned patients ≤30 years of age. The only reports with a more substantial body of data are those published by tumor registries (e.g., Surveillance, Epidemiology and End Results).…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal tract carcinoma in pediatric and adolescent age: The Italian TREP project experience

Indini

Bisogno

Cecchetto

et al. 2017

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal tract carcinoma in pediatric and adolescent age: The Italian TREP project experience

Indini

Bisogno

Cecchetto

et al. 2017

Pediatric Blood & Cancer

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“…The most common colorectal cancer is colon adenocarcinoma (COAD), which accounts for 66.1% of the disease (Ji et al, 2017). Overall COAD survival has not substantially improved over the past few decades (Liu, Chen & Xu, 2018) and its prognosis remains poor due to the delay in diagnosis, advanced stage of disease, and lack of histology-specific treatment (Al-Tonbary, Darwish & El-Hussein, 2013). Therefore, identification of novel biomarkers for early diagnosis and development of histology-specific targets is one of the foremost challenges for individual treatment of COAD.…”

Section: Introductionmentioning

confidence: 99%

Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma

Qiu

Lü

Yang

et al. 2020

PeerJ

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Colon adenocarcinoma (COAD) represents a major public health issue due to its high incidence and mortality. As different histological subtypes of COAD are related to various survival outcomes and different therapies, finding specific targets and treatments for different subtypes is one of the major demands of individual disease therapy. Interestingly, as these different subtypes show distinct metabolic profiles, it may be possible to find specific targets related to histological typing by targeting COAD metabolism. In this study, the differential expression patterns of metabolism-related genes between COAD (n = 289) and adjacent normal tissue (n = 41) were analyzed by one-way ANOVA. We then used weighted gene co-expression network analysis (WGCNA) to further identify metabolism-related gene connections. To determine the critical genes related to COAD metabolism, we obtained 2,114 significantly differentially expressed genes (DEGs) and 12 modules. Among them, we found the hub module to be significantly associated with histological typing, including non-mucin-producing colon adenocarcinoma and mucin-producing colon adenocarcinoma. Combining survival analysis, we identified glycerophosphodiester phosphodiesterase 1 (GDE1) as the most significant gene associated with histological typing and prognosis. This gene displayed significantly lower expression in COAD compared with normal tissues and was significantly correlated with the prognosis of non-mucin-producing colon adenocarcinoma (p = 0.0017). Taken together, our study showed that GDE1 exhibits considerable potential as a novel therapeutic target for non-mucin-producing colon adenocarcinoma.

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“…CRC, although rare, should be suspected and investigated in any child presenting with unexplained persistent constipation, abdominal distension or bleeding per rectum [19]. The present study reports the case of colonic carcinoma in a 15-year-old male patient without any risk factors.…”

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confidence: 79%

Metastatic Primary Adenocarcinoma of Colon: A Case Report of 15-Year-Old Boy

Ognibene¹,

Basile²,

Schiavone³

et al. 2016

JGPLD

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Colorectal carcinomas are rare disease in the pediatric population, especially without known risk factors. The present article reports the case of a 15 year old boy with sporadic colon carcinoma who presented with acute intestinal obstruction symptoms during a soccer match. An annular colonic mass proximal to the hepatic flexure causing mechanical obstruction was observed on abdominal enhanced magnetic resonance. The diagnosis was confirmed by emergency laparotomy which identified an infiltrative and stenosing colonic mass, with serosal involvement and hepatic metastasis. Histological examination of the mass revealed a moderately differentiated adenocarcinoma. The present study aimed to suggest that malignancies should be considered by pediatricians and pedi¬atric surgeons for differential diagnosis when patients present with intestinal obstruction symptoms such as unexplained persistent constipation, abdominal distension or bleeding per rectum, as early diagnosis and treatment decreases the mortality rate of patients.

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Adenocarcinoma of the colon in children: Case series and mini-review of the literature

Cited by 30 publications

References 17 publications

Gastrointestinal tract carcinoma in pediatric and adolescent age: The Italian TREP project experience

Gastrointestinal tract carcinoma in pediatric and adolescent age: The Italian TREP project experience

Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma

Metastatic Primary Adenocarcinoma of Colon: A Case Report of 15-Year-Old Boy

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