Adenocarcinoma of the Caecum in a Young Adult Presenting as Intussusception

Jain, Shivi; M, Kamalraj; Ramalakshmi,; Ross, Kannan

doi:10.36347/sasjs.2020.v06i02.009

Cited by 1 publication

(1 citation statement)

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“…A large number of observational studies have found that intestinal bacterial infections (e.g., Salmonella, Escherichia coli, Shigella, etc.) are signi cantly associated with the development of intussusception, which often occurs within one month after infection [9][10][11]. In this study, MR analysis showed that intestinal microorganisms play an important role in intestinal volvulus.…”

Section: Discussionmentioning

confidence: 55%

Relationship between gut microbiota and intussusception: an analysis based on Mendelian randomization

Cheng,

Luo,

Shang

et al. 2023

Preprint

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Objective To explore the causal relationship between intestinal microbiome and intussusception utilizing two-sample Mendelian randomization (MR) method. Methods Genome-wide association studies (GWAS) significance level data of 211 intestinal microbiome selected from the MiBioGen consortium were used as instrumental variables, and the genetic associations with intussusception was obtained from FinnGen consortium based on intestinal condyloma susceptibility genes. Inverse variance weighting (IVW), MR-Egger, Weighted median, Weighted mode and MR-PRESSO methods were used to explore the causal relationship between intestinal microbiome and intussusception. Results The inverse variance weighted results showed that Bifidobacterium was inversely associated with the risk of intussusception (OR: 0.376, 95% CI: 0.157–0.899). In addition, Ruminococcustorques group (OR: 4.461, 95% CI: 1.058–18.807), Adlercreutzia (OR: 3.893, 95% CI: 1.318–11.502), Allisonella (OR: 1.715, 95% CI: 1.009–2.915), and Clostridiumsensustricto1 (OR: 2.974, 95% CI: 1.046–8.451) suggested an increased risk association with intussusception. Conclusions The present MR study indicated that Bifidobacterium reduces the risk of intussusception and postoperative recurrent intussusception. Further randomized controlled trials are needed to elucidate the protective effects of probiotics on the development of intussusception as well as their specific protective mechanisms.

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Section: Discussionmentioning

confidence: 55%