Adenocarcinoma of supernumerary breasts of the labia majora in a case of epidermoid carcinoma of the vulva

Greene, Harry J.

doi:10.1016/s0002-9378(36)90467-2

Cited by 56 publications

(29 citation statements)

References 4 publications

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“…[52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][72][73][74] There were 2 reported cases of ductal carcinoma in situ arising in MLGs of the vulva, 49 1 reported case of perianal adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma, 50 and 2 reported cases of adenocarcinoma in situ arising in vulvar papillary hidradenoma. 51 Another unusual case of vulvar adenocarcinoma was reported with 3 different histologic features, including sweat gland carcinoma, adenocarcinoma of supernumerary mammary glands, and EMPD.…”

Section: Discussionmentioning

confidence: 99%

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Parks

Branch²,

Metcalf³

et al. 2012

The American Journal of Dermatopathology

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Hidradenoma papilliferum of the anogenital region was previously believed to originate from apocrine glands but has recently been accepted as originating from anogenital mammary-like glands. We describe a case of hidradenoma papilliferum with mixed features of syringocystadenoma papilliferum and mammary-like glands from the left labia majora of a 25-year-old woman. Histopathologically, the lesion showed an epithelial lining with apocrine secretion, and like syringocystadenoma papilliferum, the lesion extended from the epithelium as invaginations into the dermis. Adjacent to this lesion were ductal and glandular structures resembling normal mammary tissue. This review of the literature highlights the heterogeneity and complexity of lesions arising from anogenital mammary-like glands, and this case serves as further documentation of the association between anogenital mammary-like glands and hidradenoma papilliferum.

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Section: Discussionmentioning

confidence: 99%

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Parks

Branch²,

Metcalf³

et al. 2012

The American Journal of Dermatopathology

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“…48,49 In the vulva and anogenital area, the most common cutaneous lesion associated with HPV infection is condyloma (acuminatum or flat), which is mostly caused by HPV, types 6 and 11. [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] A viral etiology cannot, however, explain the rare instances of extragenital hidradenoma papilliferum. [50][51][52][53][54][55][56] In addition, some benign neoplasms in this region have been shown to harbor HPV DNA, 57,58 but as far as we are aware this has not yet been investigated in hidradenoma papilliferum.…”

Section: Discussionmentioning

confidence: 99%

Hidradenoma Papilliferum with Oxyphilic Metaplasia

Kazakov

Mikysková²,

Kutzner³

et al. 2005

The American Journal of Dermatopathology

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Reported here are 18 cases of hidradenoma papilliferum with oxyphilic metaplasia. All patients were women ranging in age from 29 to 74 years. Each presented clinically with a small, solitary tumor in the anogenital region. Microscopically, in addition to classic histopathological features, in every case there was oxyphilic metaplasia of the constituent epithelial cells. This finding could be likened to apocrine metaplasia, a term used in breast pathology. Other histopathological findings observed in this series, analogous to benign breast disease, included sclerosing adenosis-like changes, atypical apocrine adenosis-like changes, changes corresponding to usual ductal epithelial hyperplasia, epitheliomatosis with a streaming growth pattern, lamprocyte-like changes, clear cell change of the myoepithelium, foamy histiocyte reaction, and stromal fibrosis. Immunohistochemistry inferred that in the majority of cases oxyphilic metaplasia resulted from more lysosomes, whereas numerous mitochondria were detected in only 3 cases. Using 2 different PCR methods we identified HPV in 4 of 15 cases of hidradenoma with oxyphilic metaplasia. In addition, HPV was detected in 3 of 16 conventional papillary hidradenomas used as a control group. The following HPV types were identified: 16, 31, 33, 53, and 56. The last type was found in 5 cases. More than one HPV type from a single lesion was seen in 5 cases. Our observations are consistent with previous publications noting similarities between tumors of the breast and sweat glands. Oxyphilic metaplasia, areas with solid growth, and changes simulating atypical apocrine adenosis are rare and poorly recognized in hidradenoma papilliferum and may cause diagnostic difficulties; in our cases several submitting pathologists suspected malignancy. A causal role for HPV in hidradenoma papilliferum cannot be confirmed from our results, as the detection rate is too low. The exact role of the HPV in etiology and pathogenesis of this neoplasm has yet to be determined.

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“…It is now thought that the mammary tissue is in fact mammary-like anogenital glands (van der Putte 1994, van der Putte & van Group 1995). However there are rare reports of ectopic mammary glands with associated nipples occurring in the vulva (Green 1936).…”

Section: Vulval Mammary Tissuementioning

confidence: 99%

Basics of Vulval Embryology, Anatomy and Physiology

Neill

Lewis

2009

Ridley's the Vulva

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A basic knowledge of the events in the embryogenesis and organogenesis of the female reproductive tract is important in order to understand the congenital abnormalities that may arise. The female genital tract is closely linked to the development of both the urinary and terminal part of the gastrointestinal tracts, explaining why some congenital abnormalities of the female reproductive tract may be found in association with anomalies of the urinary and gastrointestinal systems.

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Adenocarcinoma of supernumerary breasts of the labia majora in a case of epidermoid carcinoma of the vulva

Cited by 56 publications

References 4 publications

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Hidradenoma Papilliferum With Mixed Histopathologic Features of Syringocystadenoma Papilliferum and Anogenital Mammary-Like Glands: Report of a Case and Review of the Literature

Hidradenoma Papilliferum with Oxyphilic Metaplasia

Basics of Vulval Embryology, Anatomy and Physiology

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